Global ETD Search
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Showing 1 to 14 of 14 for “"p75NTR"”.
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Untersuchungen über die funktionelle Rolle des Neurotrophinrezeptors p75NTR
… andererseits an den Neurotrophinrezeptor p75NTR. Obwohl p75NTR der erste klonierte Neurotrophinrezeptor war, wird die Wirkungsweise von Trk-Rezeptoren heute besser verstanden als von p75NTR. Erstens besitzen Trk-Rezeptoren als Rezeptortyrosinkinasen im Gegensatz zu p75NTR eine intrinsische …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
<p>The p75 neurotrophin receptor (p75NTR) is responsible for implementing cellular death during embryonic development and in response to cellular injury. The receptor has been recognized as a contributor of neurodegeneration in numerous pathological conditions. Cleavage of p75NTR by Tumor Necrosis …
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Analisi funzionale dei recettori per le neurotrofine p75NTR e Trka in neuroblastoma
… two distinct Neurotrophin receptors, TrkA and p75NTR. While several reports have provided lines of evidence on the interaction between TrkA and p75NTR at the plasma membrane, much fewer data are available on the consequence of such an interaction in terms of intracellular signaling. In this …
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The impact of reduced neuronal p75NTR expression on sensory neuron phenotype and associated glia
The common neurotrophin receptor, p75NTR, has been implicated in diverse responses of sensory neurons including a role in nociception following nerve injury, suggesting that it may serve a similar role in intact sensory neurons and their satellite glial cells (SGCs). To examine the impact of …
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The Role of the p75 Neurotrophin Receptor in Experimental Inflammation of the Central Nervous System
… Rolle des niedrigaffinen Neurotrophinrezeptors p75NTR in Bezug auf axonale Schädigung in der experimentellen autoimmunen Encephalitomyelitis (EAE) gezeigt. Nach EAE Induktion per aktiver Immunisierung mit dem Myelin-Oligodendrozyten-Glykoprotein-Peptid MOG35-55 zeigten p75NTR KO Mäuse einen …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
The p75 neurotrophin receptor (p75NTR) is a member of the tumour necrosis factor superfamily, which relies on the recruitment of cytosolic protein partners - including the TNF receptor associated factor 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and …
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Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… 10X Chromium. To investigate the function of a p75NTRexpressing HSC subpopulation, C57BL/6J mice received Tat-Pep57 (TP5, cell-permeable peptide inhibitor which specifically blocks the activation of Rho signalling through p75NTR) 2 hours post- AILI. Further experiments were undertaken using …
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Mitochondrial Instability, Lack of Erk1/2 Activation and High Expression of P75NTR in Engrailed-Deficient Mesencephalic Dopaminergic Neurons
Progressive loss of mesencephalic dopaminergic (mesDA) neurons is the main pathological feature of Prakinson’s Disease. The homeobox transcription factors, Engrailed-1 and Engrailed-2, are essential for survival and long-term maintenance of this neuronal population. In mutant embryos, null for both …
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The Therapeutic Role of LM11A-31 (a p75NTR Modulator) in the Outcome of Ischemic Stroke and HIV-1 Pathogenesis
… need. LM11A-31 is a p75 neurotrophin receptor (p75NTR) modulator and is orally bioavailable, and it can penetrate the intact blood-brain barrier (BBB). It is in phase II clinical trials for the treatment of mild to moderate Alzheimer’s disease. As p75NTR upregulation has been reported in both …
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Molecular Mechanisms Regulating Neurite Growth, Innervation and Survival
… on those axons the p75 neurotrophin receptor (p75NTR), which in turn causes the local degeneration of those axons. I further identified the signal transduction pathway required for axon degeneration consisting of p75NTR and intracellular signaling proteins activated by this receptor, Rho-GDI, …
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Regulation der Capsaicin-Sensitivität von murinen Spinalganglienzellen durch neurotrophe Faktoren
… nimmt und über den niederaffinen NGF-Rezeptor p75NTR Capsaicin-Empfindlichkeit, CGRP-Expression und VR1-Expression reguliert. Dieser Rezeptor hat dabei keine Bedeutung für den konstitutiven Cobalt-Uptake, jedoch für die Aufrechterhaltung des Cobalt-Uptakes in der Zellkultur. Zum anderen konnte …
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Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… Using PC12 cell mutants lacking the low affinity p75NTR receptor, we also demonstrate that this receptor is required to mediate iNOS expression, likely acting through the transcription factor nuclear factor kappa B (NF-kB). To determine if specific regions of the brain display a selective …
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… tumour necrosis factor receptor member, p75NTR. FDC-like cell lines were also analysed for neurotrophin component expression. This was to question FDCs as potential providers of paracrine neurotrophin signalling to Burkitt’s lymphoma B cells. Neurotrophin and neurotrophin receptor …
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The morphology, neurochemistry, and consequences of sympathosensory plexuses
The development, maintenance, and survival of neurons depend on the function of neurotrophins such as nerve growth factor (NGF). One population of neurons that rely heavily on NGF for axonal growth and survival is the postganglionic sympathetic neurons. Trauma or disease resulting in injury to the …