Global ETD Search
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Showing 1 to 8 of 8 for “"p75 neurotrophin receptor"”.
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
… nerve growth factor-mediated apoptosis through p75 neurotrophin receptor ligation. Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis. I show that human hepatic myofibroblasts exhibit differential responses to mature and pro-nerve growth factor/p75 neurotrophin …
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The Role of the p75 Neurotrophin Receptor in Experimental Inflammation of the Central Nervous System
… wird eine entscheidende Rolle des niedrigaffinen Neurotrophinrezeptors p75NTR in Bezug auf axonale Schädigung in der experimentellen autoimmunen Encephalitomyelitis (EAE) gezeigt. Nach EAE Induktion per aktiver Immunisierung mit dem Myelin-Oligodendrozyten-Glykoprotein-Peptid MOG35-55 zeigten …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
The p75 neurotrophin receptor (p75NTR) is a member of the tumour necrosis factor superfamily, which relies on the recruitment of cytosolic protein partners - including the TNF receptor associated factor 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
<p>The p75 neurotrophin receptor (p75NTR) is responsible for implementing cellular death during embryonic development and in response to cellular injury. The receptor has been recognized as a contributor of neurodegeneration in numerous pathological conditions. Cleavage of p75NTR by Tumor Necrosis …
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Molecular Mechanisms Regulating Neurite Growth, Innervation and Survival
… growing axons, it activates on those axons the p75 neurotrophin receptor (p75NTR), which in turn causes the local degeneration of those axons. I further identified the signal transduction pathway required for axon degeneration consisting of p75NTR and intracellular signaling proteins activated …
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The effects of anticholinesterases and β-amyloid pathology on neurotrophin signaling in the mouse brain
… (ChEi), the first-line drugs for AD, on Trk neurotrophin receptor activity in the mouse brain. We show that donepezil and galantamine, two clinically used ChEis, rapidly phosphorylated Trk receptors in the mouse hippocampus. Subsequent pharmacological studies suggest that cholinergic …
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The Therapeutic Role of LM11A-31 (a p75NTR Modulator) in the Outcome of Ischemic Stroke and HIV-1 Pathogenesis
… address the urgent medical need. LM11A-31 is a p75 neurotrophin receptor (p75NTR) modulator and is orally bioavailable, and it can penetrate the intact blood-brain barrier (BBB). It is in phase II clinical trials for the treatment of mild to moderate Alzheimer’s disease. As p75NTR upregulation …
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Mitochondrial Instability, Lack of Erk1/2 Activation and High Expression of P75NTR in Engrailed-Deficient Mesencephalic Dopaminergic Neurons
… deficiency results in increased expression of P75 neurotrophin receptor, which is causal to death of the neurons. The death of Engrailed double mutant mesDA neurons, as a direct result of high expression of P75, can be inhibited by application of TrkB/C-specific neurotrophins, BDNF, NT4 or NT3, …