Global ETD Search
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Showing 1 to 7 of 7 for “"p75 neurotrophin receptor"”.
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The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis
… nerve growth factor-mediated apoptosis through p75 neurotrophin receptor ligation. Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis. I show that human hepatic myofibroblasts exhibit differential responses to mature and pro-nerve growth factor/p75 neurotrophin …
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The Role of the p75 Neurotrophin Receptor in Experimental Inflammation of the Central Nervous System
… wird eine entscheidende Rolle des niedrigaffinen Neurotrophinrezeptors p75NTR in Bezug auf axonale Schädigung in der experimentellen autoimmunen Encephalitomyelitis (EAE) gezeigt. Nach EAE Induktion per aktiver Immunisierung mit dem Myelin-Oligodendrozyten-Glykoprotein-Peptid MOG35-55 zeigten …
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Investigation of p75 neurotrophin receptor and the role of its post-translational modifications in tumour cell motility and invasiveness
The p75 neurotrophin receptor (p75NTR) is a member of the tumour necrosis factor superfamily, which relies on the recruitment of cytosolic protein partners - including the TNF receptor associated factor 6 (TRAF6) E3 ubiquitin ligase - to produce cellular responses such as apoptosis, survival, and …
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The Effects Of Oxidative Stress On P75ntr Signaling In Dopaminergic Neurons
<p>The p75 neurotrophin receptor (p75NTR) is responsible for implementing cellular death during embryonic development and in response to cellular injury. The receptor has been recognized as a contributor of neurodegeneration in numerous pathological conditions. Cleavage of p75NTR by Tumor Necrosis …
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Molecular Mechanisms Regulating Neurite Growth, Innervation and Survival
… growing axons, it activates on those axons the p75 neurotrophin receptor (p75NTR), which in turn causes the local degeneration of those axons. I further identified the signal transduction pathway required for axon degeneration consisting of p75NTR and intracellular signaling proteins activated …
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The Therapeutic Role of LM11A-31 (a p75NTR Modulator) in the Outcome of Ischemic Stroke and HIV-1 Pathogenesis
… address the urgent medical need. LM11A-31 is a p75 neurotrophin receptor (p75NTR) modulator and is orally bioavailable, and it can penetrate the intact blood-brain barrier (BBB). It is in phase II clinical trials for the treatment of mild to moderate Alzheimer’s disease. As p75NTR upregulation …
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Mitochondrial Instability, Lack of Erk1/2 Activation and High Expression of P75NTR in Engrailed-Deficient Mesencephalic Dopaminergic Neurons
… deficiency results in increased expression of P75 neurotrophin receptor, which is causal to death of the neurons. The death of Engrailed double mutant mesDA neurons, as a direct result of high expression of P75, can be inhibited by application of TrkB/C-specific neurotrophins, BDNF, NT4 or NT3, …