Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"p73"”.
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
… differentiation. Within the p53-family, p53 and p73 have hepatic-specific functions in development and tumor suppression. Despite a growing list of p53/p73 target genes, very few of these have been studied in vivo, and the knowledge regarding functions of p53 and p73 in normal tissues remains …
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In Vivo Significance of The Mdm4 and P73 Interaction During Development and Tumorigenesis
… at E7.5 in a <em>p53</em>-dependent manner. p73, a member of the p53-family, is a transcription factor with tumor suppressor activity. <em>In vitro</em> studies show that Mdm4 binds to p73 and, further, comprehensive biochemical studies revealed that Mdm4 has higher affinity for p73 than p53. …
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Role of c-Jun in the regulation of tumor suppressor p53 homologue, p73
… factor c-Jun stabilizes and activates p73. Genetic evidences consolidated the findings, as c-jun-/- cells are defective in p73 stabilization, transcriptional activation, and are resistant to cisplatin induced apoptosis. Upon introducing c-Jun in c-jun-/- cells restores p73 …
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Investigating The Roles of P63 and P73 Isoforms to Therapeutically Treat P53-Altered Cancers
… the roles of <em>p63</em> & <em>p73</em> isoforms to therapeutically treat</strong></p> <p><strong><em>p53</em></strong><strong>-altered cancers</strong></p> <p><strong>Avinashnarayan Venkatanarayan, M.S</strong>.</p> <p><strong>Supervisory Professor: Elsa R. Flores, …
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Indigenous food patterns of low income individuals from North Central United States
Call number: LD2668 .T4 1984 P73
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Indigenous food patterns of low income individuals from North Central United States
Call number: LD2668 .T4 1984 P73
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Investigating The Roles of Tap63 and Tap73 In Cutaneous Squamous Cell Carcinoma and Lung Adenocarcinoma
<p>TP63 and TP73 (which encode p63 and p73, respectively) are highly conserved transcription factors with important roles in development and tissue homeostasis. Similar to their homolog, p53, both p63 and p73 have been shown to mediate tumor suppression in multiple tissue types. Interestingly, …
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Contribution of the DNA binding domain of p53 to regulation of its stability
… Interaction of mutant p53 with its family member p73 decreases ubiquitination, suggesting p73 can play a role in regulation of stability of mutant p53.
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Longshore current variations, Guyana, South America.
… Basement, West Bldg. / Call Number: Thesis1997 .P73. Source: Masters Abstracts International, Volume: 37-01, page: 0217. Adviser: V. C. Lakhan. Thesis (M.A.)--University of Windsor (Canada), 1997.
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Mismatch Repair Protein-Dependent Cytotoxic Signaling In Cells Treated With The Cancer Chemotherapeutic Cisplatin
… signaling via the pro-apoptotic p53 and p73 proteins, as well as double-strand break and replicative stress respondents ATM, γH2AX and Chk1 occurs independently of MMR protein status upon treatment of cells with CDDP, suggesting that these proteins are not involved in CDDP-induced, MMR …
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Regulation of TNF-alpha gene expression by TNFAIP1 as an activator or suppressor in response to lipopolysaccharide
… functions downregulation of TNF-alpha via p73. CONCLUSIONS: 1. MAP kinase, JAK, or PI3K, may be involved in TNF-α gene expression in LPS-dependent pathway. 2. TNFAIP1 expression can induce TNF-alpha production in mouse macrophages and vice versa. 3. TNFAIP1 gene expression in response to …
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Epigenetic repression of the NFATc1 transcription factor in human lymphomas
… The genes of p53 family members p63 and p73 are prominent examples for mammalian genes whose products can act both as oncoproteins and tumor suppressor genes (Hibi et al., 2000; Stiewe and Putzer, 2002), and it is likely that more genes exist which encode both tumor suppressors and …
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TAp73 regulates mitochondrial dynamics through an OPA1 axis
… identified a new molecular mechanism involving TAp73/OPA1 that controls mitochondrial morphology (Buckley et al., 2020). OPA1 drives fusion of the inner mitochondrial membrane and controls cristae remodelling, a process facilitating the execution of apoptosis. I have shown that TAp73 regulates …
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Elucidating p53’s physiological and tumourigenic roles
… least two additional paralogues of p53, p63 and p73 whose functions partially overlap. Therefore, to address the potentially distinct functions of p53 in development, maintenance and repair of normal adult tissues and in tumour suppression, I have built a unique, temporally switchable mouse model …
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Caractérisation de la dégradation du récepteur des hormones thyroïdiennes TRB[bêta]1 et effet de RanBPM sur ce processus
… modifie l'ubiquitination et la stabilité de p73 et RanBPM interagit avec USP11, une ubiquitine protéase. Par ailleurs, bien qu'il ait été démontré que la T[indice inférieur 3] induit une diminution rapide des TRs par la voie Ub-Pr, les mécanismes précis impliqués dans leur dégradation sont …
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Investigation of Exogenous Gonadotropin Treatment for Prevention of Non-Infectious Infertility and for Embryo Production Using the Prepubertal Gilt as a Model
… compared to saline (20%). FSH-LH also increased (P73%) when compared to PG600 (62%) and saline (20%) but proportions of gilts that ovulated were similar between FSH-LH and PG600 (>77%) but greater (P<0.0001) than saline (26%). FSH-LH increased (P<0.05) ovulation rate (≥19 CL) compared to PG600 …
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ELUCIDATING THE FUNCTIONS OF TAp73 IN BREAST CANCER
… staining results showed that TAp73 isoform was highly expressed in human breast cancer as compared to the normal tissue. Therefore, this project aims to elucidate TAp73 functions in breast cancer development. Using three cell type-specific TAp73 knockout MMTV-PyMT mouse breast …