Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"p65/RelA"”.
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The IRAK-1 binding protein SIMPL functions as a p65/RELA co-activator in NF-KB dependent gene expression following tumor necrosis factor-alpha stimulation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… ERK pathways, in particular increase in nuclear p65/RelA and phospho-p65/RelA leading to an increase in NFκB and AP-1 binding to DNA and sustained and hyperactive NFκB response in Arih2-/- dendritic cells. Overall, Ariadne 2 is shown to be a negative regulator in the activation of immune cells, …
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SirT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
… osteoclast numbers increase, resulting in age-related or post-menopausal osteoporosis. SirT1, the mammalian orthologue of yeast Sir2, has been shown to be a negative regulator of PPAR[gamma] and NF[kappa]B, two transcription factors important for the differentiation of osteoblasts and …
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Is there a role for NF-κB in the suprachiasmatic circadian clock?
… dimers of members of the Rel family, including p65 (RelA), p50, p52, c-Rel and Rel B. NF-κB transcription factors are required for regulating cell survival and differentiation and also are important for inflammatory and immune responses. Dysregulation of this transcription factor has been shown …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
… In addition, c-Maf physically interacts with p65/RelA. This interaction is dependent on the DNA binding domain of c-Maf and phosphorylation of p65 at serine 536. In transfected cells, overexpression of SUMO-1 or p65 decreases c-Maf transactivation of <italic>IL-4</italic>p-driven luciferase …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… the terminal stage of differentiation. The interrelation and the functional interplay of these two different proteins are not defined yet. We have shown here that the tumor suppressor TIS21 negatively regulated c-Myc expression during all-trans-retinoic acid (ATRA)-induced differentiation that …
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Caracterización de las vías de la fosfolipasa A_2 en procesos de neurodegeneración inducidos por estrés oxidativo en la retina bovina
… de pacientes que padecen degeneración macular relacionada con la edad (AMD, del inglés age-related macular degeneration). En este trabajo de tesis hemos caracterizado un modelo de sobrecarga de Fe en retinas bovinas incubadas in vitro con la finalidad de estudiar los eventos que ocurren en la …