Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"p65"”.
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Role of NF-κB p65 subunit phosphorylation by ATM in DNA damage-regulated gene expression
… NF-κB family is composed of 5 proteins (RelA/p65, RelB, c-Rel, p105/p50 and p100/p52) which assemble in dimers to form active NF-κB transcription factor. In resting cells, NF-κB complexes are bound to inhibitor proteins such as IκBα, and maintained inactive in the cytoplasm. Classical NF-κB …
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PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY
RelA/p65 is a main subunit of nuclear factor-kappaB (NF-kappaB) that regulates expression of genes involved in cell growth and survival, stress response, and inflammation, but its oncogenic or tumor-suppressive function in tumorigenesis has been highly controversial. Hundreds of NF-kappaB …
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The IRAK-1 binding protein SIMPL functions as a p65/RELA co-activator in NF-KB dependent gene expression following tumor necrosis factor-alpha stimulation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Expression des Transkriptionsfaktors NF-kappaB in Zellen des Hodgkin-Lymphoms und des großzelligen anaplastischen Lymphoms
… Zelllinien wurden die NF-kappaB-Faktoren p50 und p65 konstitutiv nukleär exprimiert. In den HD-Zelllinien fand sich zusätzlich konstitutives c-Rel, in den LCAL-Zelllinien dagegen konstitutives RelB. Diese vier Faktoren zeigten auch in den jeweiligen Zellen konstitutive Bindungsaktivität. Die …
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Dissecting the Role of Novel O-GlcNAcylation of NF-κB in Pancreatic Cancer
… Here, we report a novel finding that the p65 subunit of NF-κB is O-GlcNAcylated at serine 550 and 551 upon NF-κB activation. Importantly, the overexpression of either serine-to-alanine (S-A) single mutant (S550A or S551A) or double mutant (S550A/S551A) of p65 in PDAC cells impaired NF-κB …
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Contribution to the elucidation of the anti-inflammatory activity of Sesquiterpene Lactones
… tested using single amino acid mutants of the p65 subunit. The results confirm that p65 is alkylated by SLs, and that the alkylation of Cys38 is sufficient to inhibit p65 binding. The amount of remaining IkB-a is too low to explain the observed NF-kB inhibition. No inhibition of the IKK was …
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LncRNA Nostrill Facilitates Neuronal Antiviral Responses by Promoting NFkB-Mediated Irf7 Transcription
… neurons in the hippocampus and cortex. NFkB p65-mediated antiviral gene transcription was upregulated by TMEV infection and was correlated with Nostrill expression. In vitro, knockdown studies in neuronal cell lines showed that Nostrill regulated NFkB p65-mediated gene transcription and …
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Characterization of novel DNA binding activities at the immunoglobulin 3' enhancer
… this investigation, clones representing E2A, p65, SRY, SpiB LM02, ABF-1, and Rzra were retrieved from a plasma cell eDNA library. E2A, p65, and ABF-1 have been previously reported to bind elements within this enhancer. EMSA studies of these factors individually and in concert support previous …
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Neuroglial Mechanisms Involved In The Anti-Inflammatory Effect Of Acetate Supplementation
… (Cox)-1 and 2 protein levels, and NF-κB p65 protein level and phosphorylation at serine 468. Further, acetate treatment increased IL-4 and transforming growth factor (TGF)-β1 expression, and NF-κB p65 acetylation at lysine 310. Conversely, acetate treatment did not alter LPS-induced </p> …
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The Role of The Androgen Receptor Cofactor P44/Wdr77 In Astrocyte Activation
… expression and NF-kB activation characterized by p65 nuclear localization. We found that down-regulation of p21<sup>Cip1</sup> expression inhibited astrocyte activation induced by the p44/WDR77 deletion and was accompanied by a decreased p65 nuclear localization. While p21<sup>Cip1</sup> role in …
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Roles of NF-kB in spinal cord injury pathophysiology
… mechanisms. NeuN co-localization with NF-kB p65 and p50 revealed neuronal increases up to 24 hours, especially in the nucleus of cells, supporting activation of NF-kB p50/p65 and p50/p65-induced apoptotic gene transcription after SCI. Western blots of p65 and p50 showed no changes in their …
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Modulators of Inflammation and Steroid Receptors Regulate Proteinase Inhibitor 9 Gene Expression
… administration resulted in reduced p65 binding to a consensus NF-kappaB element. To investigate the mechanism of crosstalk between Dex-GR and NF-kappaB, we analyzed the effect of dexamethasone on induction of IkappaB-alpha, the inhibitory heterodimer of p65. Dexamethasone induced …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
… In addition, c-Maf physically interacts with p65/RelA. This interaction is dependent on the DNA binding domain of c-Maf and phosphorylation of p65 at serine 536. In transfected cells, overexpression of SUMO-1 or p65 decreases c-Maf transactivation of <italic>IL-4</italic>p-driven luciferase …
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Investigations into the vaccinia virus immunomodulatory proteins C4 and C16
… N and C termini. C16 acts at or downstream of p65 and the N terminus of C16 associated with p65 independently of PHD2-binding. Conversely, C4 acted upstream of p65, did not display an interaction with p65, and the function was restricted to its C-terminal region. Novel binding partners were …
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Biomarcadores diferenciales de la esquizofrenia
… abdominal, la prolactina, la subunidad p65 del factor nuclear potenciador de las cadenas ligeras kappa de las células B activadas (NFκB) (p65) y la prostaglandina E2 (PGE2) se han identificado como biomarcadores diferenciales de la esquizofrenia. Comparado con controles sanos, el …
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Investigating the role of histone H3 lysine 9 dimethylation in regulating disease-associated vascular smooth muscle cell gene expression
… localisation of the NFkB transcription factor p65 but significantly increased IL-1α-induced p65 binding to the IL6 promoter, correlating with reduced H3K9me2 levels. In contrast, enrichment of p65 was not observed at reported NFkB sites within the MMP3 promoter after IL-1α stimulation. Rather, …
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The Novel Long Non-Coding RNA Nostrill Regulates Intestinal Epithelial Defense Against Cryptosporidium parvum and Modulates Microglial-Mediated Neurotoxicity
… Irf7 expression through interactions with NF-κB p65, and induction of Nostrill promotes activating epigenetic histone modifications and occupancy of RNA polymerase II at the Irf7 promoter. Two positionally conserved human orthologs of Nostrill were induced in response to C. parvum infection and …
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IL-1 activation of NF-kB contributes to perinatal hypoxia/ischemia induced cell death
… analyses for NF-kB activity showed increased p65/p50 DNA-binding activity at 24h post-HI. Western blot analyses and immunofluorescent staining showed significant nuclear translocation of p65. Protein expression levels of iNOS and COX2, known to be transcriptionally regulated by NF-kB, also …
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An assessment of the effects of novel anti-inflammatory compounds in cell based studies
… the TNF-α-induced translocation of NF-κB (p65) to the nucleus assessed by indirect immunoflouresnce. This effect of AIK18/85/1 was also reflected in the significant reduction of nuclear extract NF-κB-DNA binding activity as detected by Electrophoresis Mobility Shift Assay (EMSA), but …
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Characterization of novel immunomodulatory proteins encoded by parapoxvirus ORF virus
… subunits IKKα and IKKβ, IκBα and NF-κB subunit p65 (NF-κB-p65), and to early nuclear translocation of NF-κB-p65 in virus-infected cells (≤ 30 min post infection). Consistent with observed inhibition of IKK complex activation, ORFV073 interacted with the regulatory subunit of the IKK complex …
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