Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"p63"”.
-
Identification of microRNA 302 as an antagonist to p63 expression
… Untersuchung, ob microRNAs an der Regulation von p63 und p53 beteiligt sind, wurde eine immunofluoreszenzbasierte Serienuntersuchung durchgeführt. '5637' Urothel-Karzinomzellen wurden mit einer Sammlung von microRNA-Expressionsplasmiden transfiziert und zelluläres p63 und p53 wurden durch …
-
Die Interferenz des Tumorsuppressor-Homologen p63 mit dem kanonischen Wnt-Signalweg
Das Tumorsuppressorhomolog p63 hat eine essentielle Rolle in der korrekten Entwicklung des mehrschichtigen Epithels, der Extremitätenknospen und der Hautanhangsgebilde, wie Haarfollikel, Zähne und Drüsen. Ebenfalls notwendig für die Entwicklung dieser Gewebe ist die regulierte Aktivität des …
-
Investigating The Roles of The P63 Isoforms In The Microrna Biogenesis Pathway
… My thesis work has demonstrated roles for <em>p63, </em>a <em>p53</em> family member, in the upstream regulation of microRNA biogenesis. The <em>p63</em> gene has a complex gene structure and has multiple isoforms. The <em>TAp63</em> isoforms contain an acidic transcription activation domain. …
-
Investigating The Roles of P63 and P73 Isoforms to Therapeutically Treat P53-Altered Cancers
<p><strong>Investigating the roles of <em>p63</em> & <em>p73</em> isoforms to therapeutically treat</strong></p> <p><strong><em>p53</em></strong><strong>-altered cancers</strong></p> <p><strong>Avinashnarayan Venkatanarayan, M.S</strong>.</p> <p><strong>Supervisory Professor: Elsa R. Flores, …
-
Investigating The Role of The P63 Isoform Δnp63 In Lung Stem Cell Populations and Lung Cancer
… adenocarcinoma and squamous cell carcinoma. ΔNp63 is known to regulate lung development but its role in lung cancer progression remains unclear. We utilized a ΔNp63-specific conditional knockout mouse model to determine ΔNp63’s role in lung progenitor cells and lung cancer. In vivo and in vitro …
-
More than skin deep: Gene regulation orchestrated by the transcription factor p63 in development and disease
Contains fulltext : 155618.pdf (Publisher’s version ) (Open Access)
-
The Effects of Gain of Function Mutant p53 and p63 on EPS8 and CXCL5 Expression in Head and Neck Squamous Cell Carcinoma
… our hypothesis that GOF mutant p53 enhances, and p63 inhibits, EPS8 and CXCL5 expression and promoter activity. We found decreased EPS8 expression, CXCL5 expression, and cellular migration associated with the loss of GOF mutant p53. This indicates an enhancing role of GOF mutant p53 in cellular …
-
Novel proapoptotic p63 isoforms are driven by an endogenous retrovirus in the male germ line of humans and great apes, likely increasing genome stability
TAp63, ein Homolog des Tumorsuppressors p53, hat die Fähigkeit, die weibliche Keimbahn zu beschützen, indem es Oozyten mit schweren DNA-Schäden nach Bestrahlung eliminiert. Obwohl die Expression von TAp63 in männlichen Keimbahnzellen vermutet wird, ist noch unklar, ob TAp63 auch als Wächter der …
-
The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression of Mir-205 In Human Bladder Cancer Cells
<p>p63, a p53 family member, is a transcription factor that has complex roles in cancer. This study focuses on the role of the ∆Np63α isoform in bladder cancer (BC). Epithelial – mesenchymal transition (EMT) is a physiological process that plays an important part in metastasis and drug resistance. …
-
PHENOTYPIC AND MOLECULAR CHARACTERIZATION OF A NOVEL P63ALPHA;KO MOUSE MODEL
The transcription factor p63, a p53 gene family member, plays a crucial role in embryonic development of stratified epithelia where it can function either as an activator or a repressor. In the epidermis, p63 is a master regulator of epidermal gene expression and is crucial for cell proliferation, …
-
Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development. Role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and Polycomb chromatin remodelling factors.
… previously shown that the transcription factor p63, a master regulator of skin development, controls the expression of adhesion molecules and essential cytoskeleton components. It has also been shown that p63 plays an important role in establishing distinct three-dimensional conformations in the …
-
MUTANT P53 REGULATION OF CXC-CHEMOKINE EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA
… from our lab suggested that the p53 homolog, p63, may function as a negative regulator of CXCL5 and that mutant p53 may inhibit this molecule to elevate CXCL5 expression levels. In the current study we utilized an model system in which the H179L p53 mutant was expressed in HN4 cells to …
-
Δnp63 Regulates A Complex Network of Target Genes In Limb and Epidermal Development
… is mediated by stem cells in the basal layer. p63 is structurally and functionally related to p53. In spite of their structural similarities, p63 is critical for the development and maintenance of stratified epithelial tissues, unlike p53. p63 is highly expressed in the epidermis and previously …
-
Evolution of H₂S and SO₂ during rapid heating of pulverized coal and sulfur containing model compounds
Call number: LD2668 .T4 1979 P63
-
Investigating The Roles of Tap63 and Tap73 In Cutaneous Squamous Cell Carcinoma and Lung Adenocarcinoma
<p>TP63 and TP73 (which encode p63 and p73, respectively) are highly conserved transcription factors with important roles in development and tissue homeostasis. Similar to their homolog, p53, both p63 and p73 have been shown to mediate tumor suppression in multiple tissue types. Interestingly, …
-
Einfluss der MAP-Kinase ERK3 (p97) auf EBV-positive Burkitt-Lymphom-Zellen
… ERK3 (p97) and the related MAP-kinase ERK3 (p63) and the Proteinkinase C was investigated. In both cases a decrease of protein expression level of ERK3 (p63) and the Proteinkinase C could be observed in Raji cells showing an overexpression of ERK3 (p97). In conclusion ERK3 (p97) seems to be …
-
Characterisation of the role of ING5
… member of the ING family to be interacting with p63 and p73. ING5 interacts with p63 and p73 both in vitro and in vivo to differentially modulate p63 and p73-mediated transactivation of bax, p21 and pig3 genes. While one important function of p53 is to prevent S phase entry in response to …
-
Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
<p>p63 is a member of the p53 family, a well-known tumor suppressor which is considered the guardian of the genome. The <em>TP63</em> gene encodes multiple isoforms that can be categorized into two main isoforms, TAp63 and ΔNp63, which are expressed in different cellular compartments and have …
-
A PERTURB-SEQ SATURATION MUTAGENESIS APPROACH TO DISSECT THE MOLECULAR BASES OF GENETIC DISEASES
… decided to apply it to mutagenize two regions of P63 (a portion of the DNA Binding Domain and the SAM domain), a transcription factor that, besides an oncogenic function, is mainly a regulator of skin development. To follow the biological activity of each generated variant, we set up a very …
Page 1 of 3