Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"p62 protein"”.
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The intrinsic role of SOCS1 in intestinal epithelial cells
The SOCS1 protein negatively regulate cytokine signaling. To define its role in intestinal epithelial cells (IEC), our laboratory created a mouse model of Socs1 gene deletion in IEC lineages of the small and large intestines. Analysis of this Socs1ΔIEC mouse model suggests that lethal ulcerative …
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The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins
… the most common movement disorder. α-synuclein protein is thought to be the main aetiological agent of PD and DLB, particularly when levels are increased in substantia nigra (SN) dopaminergic neurons, causing cell death. Current PD and DLB treatments are symptomatic and do not target the disease …
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The Nuclear Pore Complex: Novel Glycoprotein Constituents
… Thus far, almost nothing is known about the proteins that comprise this organelle. In this thesis, I describe the production of anti-nuclear monoclonal antibodies and their use in identifying some of the constituents of the nuclear pore complex. In particular, I describe studies using an …