Global ETD Search
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Showing 1 to 5 of 5 for “"p53 stability"”.
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Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… deficiency correlates with increased genomic instability in ovarian cancer specimens and breast cancer cell lines. Here, we propose that additional functions of BRIT1 include a direct interaction with the p53 tumor suppressor protein to promote p53 stability, and binding and recruitment of …
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Influence of genotoxic drug-induced post-translational modifications on mutant p53 stability and oncogenic activities
The tumour suppressor p53 is often disrupted by missense mutations that can result in p53 protein accumulation and acquisition of novel oncogenic activities. Various studies have demonstrated that DNA-damaging drugs currently used in the clinic aimed at activating wild type p53, can also stabilise …
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Investigation into the molecular mechanisms underlying circadian rhythm disruption and human cancer
… body and directly binds to the tumor suppressor p53 and its negative regulator, the oncogenic mouse double minute-2 (MDM2) protein. PER2 modulates p53 transcriptional activity by preventing MDM2-mediated ubiquitination and subsequent proteasomal degradation, promoting p53 stability. Critically, …
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New Targets of p53 Regulation: From Aging to Immune Response
… novel functions of the universal stress sensor, p53. The first study describes a novel genetic model system to address the effects of p53 dosage in an in vivo context. By developing an allelic series through multiple genetic crosses, I obtained mice with incrementally increasing levels of …
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P53R245W Mutation Elicits Metastatic Phenotype In Pten Deficient Prostate Cancer
<p><em>Trp53</em> mutations are the most frequent genetic alterations in prostate cancer and are associated with more aggressive disease and worse overall survival. The majority of <em>Trp53</em> mutations in prostate cancer are missense mutations, resulting in amino acid substitutions with …