Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"p53 restoration"”.
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Therapeutic Efficacy of P53 Restoration In Mdm2-Overexpressing Tumors
<p>The<em> TP53 </em>tumor suppressor is the most mutated gene in human cancers. Recent studies using genetically modified mouse models have shown that restoring the expression of wild-type <em>p53</em> has led to tumor growth suppression in various types of tumors lacking p53. Other mechanisms, …
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Evaluating The Therapeutic Efficacy of Restoring Wild-Type P53 Activity In P53-Mutant Tumors
<p>The p53 transcription factor is the most frequently altered in human cancers usually via missense mutations that undermine its transcriptional activity. Clinically, <em>TP53</em> mutations have been shown to be remarkably predictive of refractoriness to treatment, resulting in poor outcome. …
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Gain-of-function and dominant-negative effects of distinct p53 mutations in lung tumours
… limited therapeutic benefit in most cases. TP53 (Trp53, p53) mutations occur in approximately 50% of lung adenocarcinoma cases and are associated with poor prognosis and so novel therapies that target these p53 mutant lung tumours are urgently needed. Despite the high frequency of p53 …
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ELUCIDATING THE MOLECULAR DETERMINANTS OF P53-MEDIATED PLEIOTROPIC EFFECTS IN SMALL CELL LUNG CANCER
… with the retinoblastoma (Rb) tumor suppressor, p53 is inactivated in the vast majority (>90%) of SCLC cases. p53 is a pleiotropic tumor suppressor gene that responds to a wide array of genotoxic and cellular stresses to effectuate diverse tumor suppressive programs such as activation of cell …
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Modelling timing in blood cancers
… first investigates the therapeutic efficacy of p53 restoration in a lymphoma mouse model. While several therapy schedules are tested, all fail due to resistance emergence. Computational modelling establishes the cell dynamics in these tumours and how to use it to propose alternative treatment …