Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"p53 protein"”.
-
H2O2-mediated oxidation and nitration enhances DNA binding capacity / DNA repair via up-regulated epidermal wild-type p53 in vitiligo.
… oxidative stress on the function of many proteins and peptides due to oxidation of target amino acid residues in their structure including L-methionine, L-tryptophan, L-cysteine and seleno cysteine (Rokos, Beazley et al. 2002; Gillbro, Marles et al. 2004; Hasse, Kothari et al. 2005; …
-
Mechanisms of 17-beta-estradiol regulation of the proto-oncogene Bcl-2 in MCF-7 human breast cancer cells.
… Bcl-2 expression is the tumour suppressor gene, p53. We investigated the effects of various mutant p53 proteins and low levels of p53 on Bcl-2 expression in MCF-7 cells. Neither MCF-7/E6 cells expressing virtually undetectable levels of p53 nor MCF-7/173L cells expressing a DNA binding domain …
-
The Cytotoxic Effects of Malondialdehyde on Human Lung Fibroblast Cells
… has been linked to smoking. Mutations in the TP53 tumour suppressor gene are associated with half of all cancers. This research applied a multidisciplinary approach to investigate the toxic effects of MDA on the human lung fibroblasts MRC5, which have an intact p53 response, and their SV40 …
-
Heat stress: A risk factor for skin carcinogenesis
… Heat stress induces upregulation of heat shock proteins (HSPs), particularly HSP72 and HSP90 which are known to affect the activity of the p53 protein. Furthermore, heat stress has been linked with increased Sirtuin1 (SIRT1) protein activity. SIRT1 is an important histone deacetylase that helps …
-
The Role of Nucleolin Phosphorylation by CK2 in Regulating Cellular Fate Under Normal and Stress Conditions
… genotoxic stress-responsive RNA binding phosphoprotein. NCL constitutes 10% of total nucleolar protein that has functions in multiple biological processes, including ribosome biogenesis, DNA/RNA metabolism, cellular response to DNA damage, cell growth, proliferation and death. In this …
-
Perillyl alcohol and perillic acid enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro
… cell death via apoptosis and a reduction in p53 protein in SCC-25 cells.
-
Targeting mutant p53 in cSCCs
… patients with multiple cSCCs.<br/><br/>Wild-type p53 (wt-p53) has been shown to prevent cSCC development and induce tanning and sunburn responses in skin cells. However, TP53 mutations are found in over half of all human cancers and cSCC is no exception as TP53 mutational frequency in cSCCs is …
-
Influence of genotoxic drug-induced post-translational modifications on mutant p53 stability and oncogenic activities
The tumour suppressor p53 is often disrupted by missense mutations that can result in p53 protein accumulation and acquisition of novel oncogenic activities. Various studies have demonstrated that DNA-damaging drugs currently used in the clinic aimed at activating wild type p53, can also stabilise …
-
Molecular pathways controlling DNA damage response
P53 is inactivated in around 50 % of human neoplasms and more than 26,000 somatic mutations of the p53 have reported in human cancers. P53 network is activated after cells are exposed to the DNA damage and depending on diverse conditions and type of DNA damage, p53 upregulation could lead to …
-
An investigation of mutant p53 function.
The TP53 tumour suppressor gene is mutated in approximately 50% of all human cancers. The majority of these mutations are missense mutations resulting in the expression of a mutated form of the full-length p53 protein. This mutant protein exhibits a loss of tumour suppressive activity, …
-
p53 activity during adenovirus infection
… Entdeckung ist, dass adenovirale Onkoproteine zelluläre Tumorsuppressor Signalwege inaktivieren können und somit das Tumorwachstum fördern. p53 ist einer der wichtigsten Tumorsuppressoren in der Zelle, welcher die zelluläre genomische Integrität aufrecht erhält. Die p53 Funktion ist in …
-
The germline- and tissue-specific effects of endogenous point-mutant p53
p53 is frequently altered in human tumors through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of- function properties to p53. To ascertain the physiological effects of tumor-associated point- mutations in p53, the …
-
Using Stable Limit Cycles to Model p53-Mdm2 Protein Interactions in the Presence of DNA Damage
The protein p53 is constantly made and destroyed within a cell. Another protein, Mdm2, is a negative regulator of p53. In the presence of DNA damage, Mdm2 does not bind to p53, thus activating the p53 protein. This activation then promotes the mechanisms necessary to either fix or terminate the …
-
Proteolysis targeting chimeras for the directed ubiquitination of the androgen receptor
… drug candidates. PROTACs consist of a target protein binder connected via a linker to an E3 ligase binder. PROTACs hijack the ubiquitin proteasome system to degrade the target protein in a cellular environment. This work focuses on the androgen receptor (AR) protein, a key nuclear receptor for …
-
p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts
… cells of mice with a deletion allele for the Trp53 gene, to explore both the regulation of p53, and its downstream functions mediated by specific activation of target genes. Chapter 2 addresses the regulation of nuclear localization of the p53 protein. Previous reports in the literature had …
-
Discovering the p53 isoforms’ code
p53 has a key role in the maintenance of the genetic stability and, thus, in preventing tumour development. The current model is that the p53-dependent responses are solely driven by p53α. The uncovering that the TP53 gene physiologically expresses several p53 isoforms, challenges this paradigm. …
-
Study of the Gain-of-Function Mutant p53 and PARP1 in Triple-Negative Breast Cancer
<p>Cancer cells often lose expression of the p53 protein or express mutant forms of p53. Some of these mutant p53 proteins, called gain-of-function mutant p53, have gained oncogenic functions. Previously, our group observed mutant p53 R273H interacts with replicating DNA and upregulates the …
-
Development of orthogonal nanotherapeutics for colorectal cancer treatment
The tumour suppressor p53 has an impressive ability to regulate multiple cellular events such as apoptosis and cell cycle. Strategies aimed at activating the wild-type p53 convene a great therapeutic potential. This led to the discovery of the small molecule inhibitors, MDM2 antagonists which …
-
The role of p53 in virus-induced and multi-step lymphomagenesis
It has previously been demonstrated that p53 loss and Moloney murine leukaemia virus (MMLV) infection are weakly collaborative in T cell lymphomagenesis. The work described in this thesis aimed to investigate the role of p53 in MMLV-induced lymphoma and explore the basis of their relatively weak …
-
Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia
… poorly to therapy. The tumor suppressor gene, TP53 is located on this region and it is well established that the p53 protein regulates multiple functions including: mitochondria biogenesis, response to DNA damage and redox balance. The objectives of the study were to determine the status of …
Page 1 of 3