Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"p53 mutation"”.
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Exploiting p53 mutation in colorectal cancer: clinical positioning of Cdc7 inhibitors
Mutations in TP53 are present in approximately 50% of colorectal cancer (CRC) and are enriched for in the metastatic setting. As a result of TP53 mutation these tumours are limited in their ability to execute tumour-suppressive functions. Synthetic lethal targeting of pathways/ proteins on which …
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Novel Oligomeric Fluoropyrimidines and Their Efficacy for the Treatment of Colorectal Carcinoma Independent of p53 Mutation
… to the dependency 5-FU displays towards normal p53 function, a tumor suppressor protein that is commonly mutated in advanced CRC. In addition to the relatively low success rate of 5-FU in aggressive CRC, 5-FU treatment also causes systemic toxicity, particularly to the GI-tract. The presented …
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Genetic Alterations in Advanced Head and Neck Cancer
… repeat sequences (MI) seems to concur with PTEN mutation in endometrial and colorectal cancer. <br>We screened a panel of SCCHN for LOH at 10q23 using the microsatellite marker D10S541. In addition, instability of 11 microsatellite loci of 8 different chromosomes was determined. Also, all tumors …
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A GNAQ/11-driven zebrafish cancer model identifies MITF and YAP as key determinants for uveal melanoma
… melanoma (CM), which is driven by oncogenic mutation of BRAF or NRAS, UM is driven by oncogenic mutations in GNAQ or GNA11 (>80% of patients). We developed a zebrafish model of UM by expressing GNAQ[superscript Q209L] in the melanocytes of p53-/- zebrafish. In this model, oncogenic GNAQ …
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The Expression and Function of Wilms' Tumor 1 in Malignant Glioma
… screening of the glioblastoma specimens for p53 mutation followed by logistic regression analysis demonstrated a positive correlation between WTl expression and wild-type p53 (p = 0.04). To determine if WTl and p53 functionally interacted, we generated LN-229 glioblastoma cells that stably …
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The role of molecular, clinical and socioeconomic factors in the long-term survival of axillary node negative breast cancer patients
… factors included stage, histopathologic grade, p53 mutation, Her-2/neu amplification, estrogen receptor status (ER), progesterone receptor status (PR) and vascular invasion. Census derived socioeconomic (SES) indicators included median individual and household income, proportions of university …
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Tissue-specific interactions between oncogenic K-ras and the p19A̳r̳f̳_p53 pathway determine susceptibility to transformation
… by the collective action of gain-of-function mutations in oncogenes and loss-of-function alterations in tumor suppressor genes. The particular spectrum of mutations in a given cancer is rarely the result of random chance but instead derives from the intimate connections between proliferative …
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Uncovering p53 Mutations and Abnormal Gene Expression in Pediatric Adrenocortical Cancer
… it is well-known that the tumor suppressor p53, which is mutated in over 50% of all human cancers, is commonly mutated in pediatric adrenocortical cancer. In addition, evidence strongly suggests that if a child has adrenocortical cancer, it indicates a germline p53 mutation exists.</p> <p>In …
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Investigation into the molecular mechanisms underlying circadian rhythm disruption and human cancer
… body and directly binds to the tumor suppressor p53 and its negative regulator, the oncogenic mouse double minute-2 (MDM2) protein. PER2 modulates p53 transcriptional activity by preventing MDM2-mediated ubiquitination and subsequent proteasomal degradation, promoting p53 stability. Critically, …
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The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
… are defective, containing premature stop mutations and frameshift mutations, a number encode fully functional proteins. HERVs have been proposed as aetiological agents for a variety of autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus, and multiple …
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Humoral immunity in colorectal cancer : evaluation of the anti-p53 and anti-hTERT auto-antibody responses
… in the "2-hit" hypothesis which are overcome by p53 dysfunction (M1) and hTERT re-expression (M2). These two molecular events generate TAA which are recognised by the humoral immune system with a corresponding auto-antibody response. The aim of this thesis was to investigate the significance of …
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Molecular changes involved in oral cancer progression and their relevance to keratinocyte immortalisation
… (RAR)-b and the cell cycle inhibitor, p16INK4a, p53 mutations and increased levels of telomerase/hTERT mRNA. In contrast, increased expression of the EGF receptor (EGF-R), known to be a characteristic of oral cancer, does not occur until after the dysplasia stage in squamous cell carcinomas …
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Gain-of-function and dominant-negative effects of distinct p53 mutations in lung tumours
… limited therapeutic benefit in most cases. TP53 (Trp53, p53) mutations occur in approximately 50% of lung adenocarcinoma cases and are associated with poor prognosis and so novel therapies that target these p53 mutant lung tumours are urgently needed. Despite the high frequency of p53 …
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Bead-basierte Fluoreszenz-Immunoassays zum Nachweis tumorinduzierter Proteine
… contrast, autoantibodies against tumorsuppressor p53 can be detected in blood serum 100 days after tumor development. As a diagnosis in this early stage is supposed to result in successful therapy in 80 percent of the cases. Hence, these antibodies are promising candidates in research of tumor …
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UNDERSTANDING THE RELATIONSHIP BETWEEN ONCOLYTIC AD5 DELETED E1b55KDA LYTIC INFECTION AND P53 IN MAMMALIAN CELLS
… replicate in and kill tumor cells. The p53 molecule is a tumor suppressor protein that responds to viral infection through the activation of apoptosis, which is inhibited by adenovirus E1B55kDa protein leading to progressive viral lytic cycle. The non-specificity of replication has …
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Identifikation von Mutationen im Tumorsuppressorgen p53 und des Bakteriums Helicobacter pylori in Magenkarzinomen histopathologischer Präparate aus verschiedenen medizinhistorischen Sammlungen
… zu rezenten gibt. Als typisches Zielgen für Tumormutationen wurde das Tumorsuppressorgen p53 untersucht. Au¬ßerdem wurde Helicobacter pylori (H. pylori) als Risikofaktor für die Entstehung von Magenkarzinomen in den historischen Proben identifiziert. Insgesamt standen 51 Gewebeproben von …
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Gain-of-Function Effects of Mutant p53 Explored Using a Three-Dimensional Culture Model of Breast Cancer
p53 is the most frequent target for mutation in human tumors and mutation at this locus is a common and early event in breast carcinogenesis. Breast tumors with mutated p53 often contain abundant levels of this mutant protein, which has been postulated to actively contribute to tumorigenesis by …
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An investigation of mutant p53 function.
The TP53 tumour suppressor gene is mutated in approximately 50% of all human cancers. The majority of these mutations are missense mutations resulting in the expression of a mutated form of the full-length p53 protein. This mutant protein exhibits a loss of tumour suppressive activity, …
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Assessment of immunological responses to tumour antigens relevant to the development of therapeutic cancer vaccines
P53 protein that has been referred to as the "guardian of genome". It acts to suppress tumour development through mechanisms involving cell cycle arrest, DNA repair, senescence and apoptosis. Loss of the tumour-suppressive activity in p53 is a frequent event, occurring in more than 50% of all types …
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Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head and Neck Squamous Cell Carcinoma
… high rate of treatment failures in HNSCC. TP53 is the most frequently mutated gene in HNSCC, and the effect of p53 loss or mutation on cisplatin responses in HNSCC is poorly understood. In the current study, we hypothesized that HNSCC cells respond to cisplatin in a p53 dependent manner and …
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