Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"p53 knockdown"”.
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Exploring the Functional Interaction Between CaMK-II and p53
… mutants”, tumor suppressor protein 53 (p53) was identified as a novel CaMK-II binding partner in tissue culture. In this study, I sought to provide characterization of the functional interaction of p53 and CaMK-II. First, a stable p53 knockdown human cell line (HEK) was established …
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Role of p53 and its isoforms in the expression of FGF-2 and tumoral neovascularization
The tumour suppressor p53 actually exists as 9 protein isoforms. Among them, D133p53a, b and g result from the use of an alternative promoter and lack the N-terminal transactivation domain. In addition to its multiple functions maintaining cell integrity, p53 is also able to block angiogenesis, a …
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The Effects of Tarsh Overexpression on Lung Carcinomas
… Tarsh is likely dependent upon the expression of p53, a tumor suppressor gene. The current study investigated these results, in addition to the biological effects of ectopically increasing Tarsh and/or knocking down p53 expression in two lung cancer cell lines: A549 and H1299 cell lines. It was …
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hCLCA2 IS A p53-REGULATED GENE REQUIRED FOR MESENCHYMAL TO EPITHELIAL TRANSITION IN BREAST
… and aphidicolin potently induced hCLCA2 in p53-positive cell lines such as MCF-7 but not in p53-deficient cells such as MDA-MB231. An adenovirus encoding p53 induced hCLCA2 expression in a broad spectrum of breast cancer cell lines while a control virus did not, suggesting that hCLCA2 is a …
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Targeting mutant p53 in cSCCs
… patients with multiple cSCCs.<br/><br/>Wild-type p53 (wt-p53) has been shown to prevent cSCC development and induce tanning and sunburn responses in skin cells. However, TP53 mutations are found in over half of all human cancers and cSCC is no exception as TP53 mutational frequency in cSCCs is …