Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"p53 interaction"”.
-
Preclinical Pharmacology of the MDM2 Antagonist Nutlin-3a
<p>Nutlin-3a is an MDM2-p53 interaction antagonist that is under investigation in preclinical models for a variety of pediatric malignancies, including neuroblastoma, retinoblastoma, leukemia, and rhabdomyosarcoma. In the current research, we conducted preclinical pharmacology studies of nutlin-3a …
-
Brit1/Mcph1 Mediates The Dna Damage Response By Inducing P53 Stability and Promoting Atr Signaling
… additional functions of BRIT1 include a direct interaction with the p53 tumor suppressor protein to promote p53 stability, and binding and recruitment of TopBP1 to sites of replication stress to maintain ATR signaling.</p> <p>The stability of p53 is largely dependent on its negative regulator, …
-
Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage
… The first elucidates the regulation of RPA and p53 interaction by DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) in homologous recombination (HR). HR and nonhomologous end joining (NHEJ) are 2 distinct DNA double-stranded break (DSB) …
-
Dissecting The Interaction Between P53 and Trim24
<p>Dissecting the Interaction of p53 and TRIM24</p> <p>Aundrietta DeVan Duncan</p> <p>Supervisory Professor, Michelle Barton, Ph.D.</p> <p>p53, the “guardian of the genome”, plays an important role in multiple biological processes including cell cycle, angiogenesis, DNA repair and apoptosis. …
-
Delineating mechanisms which underlie differential cell fates induced by p53 activation and HDAC inhibition in colorectal cancer
The tumour suppressor p53 is the most frequently mutated gene in human cancer with loss or suppression of wild-type function thought to be a prerequisite for the development of most malignancies. In colorectal cancer (CRC), approximately 50% of tumours harbour mutations in the TP53 gene, whilst the …
-
The Role of Histone H2B Ubiquitylation and its Related Factors in Transcriptional Regulation in Mammalian Cells
… I show that hBRE1A/B directly interacts with p53 and that it is recruited to the mdm2 promoter in a p53-dependent manner. These studies suggest that hBRE1A/B is an H2B-specific E3 ubiquitin ligase and that it functions, at least in part, through direct activator interactions, as a …