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Showing 1 to 11 of 11 for “"p53 family"”.
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Investigating The Roles of P63 and P73 Isoforms to Therapeutically Treat P53-Altered Cancers
… treat</strong></p> <p><strong><em>p53</em></strong><strong>-altered cancers</strong></p> <p><strong>Avinashnarayan Venkatanarayan, M.S</strong>.</p> <p><strong>Supervisory Professor: Elsa R. Flores, Ph.D</strong>.</p> <p>The <em>TP53</em> tumor suppressor is mutated in approximately …
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New Target Genes For Tumor Suppressors P53 and P73 In Regenerating Liver
The p53-family of proteins regulates expression of target genes during tissue development and differentiation. Within the p53-family, p53 and p73 have hepatic-specific functions in development and tumor suppression. Despite a growing list of p53/p73 target genes, very few of these have been studied …
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Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
<p>p63 is a member of the p53 family, a well-known tumor suppressor which is considered the guardian of the genome. The <em>TP63</em> gene encodes multiple isoforms that can be categorized into two main isoforms, TAp63 and ΔNp63, which are expressed in different cellular compartments and have …
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Investigating The Roles of Δnp63 As A Suppressor of Migration, Invasion, and Metastasis
… on studying the role of ΔNp63 in cancer, a p53 family member known to be involved in epithelial development, microRNA biogenesis, and stem cell maintenance. Using the strength of <em>in vivo </em>mouse models, we found that ΔNp63 is capable of modulating tumor development by regulating the …
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Epigenetic repression of the NFATc1 transcription factor in human lymphomas
… function in tumor development. The genes of p53 family members p63 and p73 are prominent examples for mammalian genes whose products can act both as oncoproteins and tumor suppressor genes (Hibi et al., 2000; Stiewe and Putzer, 2002), and it is likely that more genes exist which encode both …
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In Vivo Significance of The Mdm4 and P73 Interaction During Development and Tumorigenesis
<p>The tumor suppressor protein p53 is negatively regulated by Mdm4 protein. The significance of such regulation was determined from mouse models. Mdm4-deficient mice are embryonic lethal at E7.5 in a <em>p53</em>-dependent manner. p73, a member of the p53-family, is a transcription factor with …
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The P63 Isoform ∆Np63Α Inhibits Epithelial – Mesenchymal Transition By Promoting The Expression of Mir-205 In Human Bladder Cancer Cells
<p>p63, a p53 family member, is a transcription factor that has complex roles in cancer. This study focuses on the role of the ∆Np63α isoform in bladder cancer (BC). Epithelial – mesenchymal transition (EMT) is a physiological process that plays an important part in metastasis and drug resistance. …
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Elucidating p53’s physiological and tumourigenic roles
The key role of p53 as a tumour suppressor is widely acknowledged and based on many observations that p53 suppresses oncogene-mediated transformation of rodent fibroblasts and is the most frequently mutated gene in human cancers. However, the p53 family of transcription factors is evolutionarily …
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HUMAN CLCA2 IS A P53-DEPENDENT ZINC METALLOPROTEASE AND ITS INTERACTION WITH EVA1 MAINTAINS DIFFERENTIATION OF HUMAN MAMMARY EPITHELIAL CELLS
CLCA2 is a p53-inducible transmembrane protein that is frequently downregulated in breast cancer. CLCA2 is a 943 amino acid type I transmembrane protein that is cleaved near amino acid 700 to produce a diffusible 100kD product. The N-terminus contains a hydrolase-like domain with well-conserved …
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TAp73 regulates mitochondrial dynamics through an OPA1 axis
Mitochondria are energy-producing organelles. They are highly adaptive and undergo the processes of fusion and fission to couple mitochondrial function with changing cellular demands. In this thesis, I have identified a new molecular mechanism involving TAp73/OPA1 that controls mitochondrial …
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Investigating The Roles of Tap63 and Tap73 In Cutaneous Squamous Cell Carcinoma and Lung Adenocarcinoma
… tissue homeostasis. Similar to their homolog, p53, both p63 and p73 have been shown to mediate tumor suppression in multiple tissue types. Interestingly, however, both genes are expressed as multiple isoforms, which appear to have different and, in many cases, antagonistic functions. Through …