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Showing 1 to 6 of 6 for “"p53 Tumor suppressor Gene"”.
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Analysis of the Transcriptional Regulation and Bidirectional Nature Of the Promoter of the p53 Tumor Suppressor Gene
<p>p53 is a tumor suppressor protein that plays a role in many cellular processes ranging from cell cycle regulation to apoptosis. The protein's role as a transcription factor has shown that deregulated transcription, whether increased (as with mutant p53 transcription) or decreased (failure to …
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Investigation of the p53-dependent apoptosis versus arrest decision through analysis of Prep gene regulation
The p53 tumor suppressor gene is thought to play a critical role in the maintenance of genetic integrity by virtue of its ability to check the growth of abnormal or damaged cells through initiation of the cell cycle arrest and apoptosis pathways. p53 itself is mutated in roughly half of all human …
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Attitudes of Parents At Risk of Inheriting Li-Fraumeni Syndrome to wards Predictive Genetic Testing In Their Minor-Aged Children.
… early childhood to adulthood. Mutations in the p53 tumor suppressor gene are known to cause the majority of cases of LFS. The risk for early onset cancer in individuals with Li-Fraumeni Syndrome is high. Studies have shown that individuals with LFS have a 90% lifetime cancer risk. Children under …
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REDEFINING THE SCOPE OF PRENYLATION: DISCOVERY OF “FORBIDDEN” SUBSTRATE RECOGNITION AND DEVELOPMENT OF METHODS UTILIZING PRENYLATED PROTEINS
… studies of these enzymes. However, recent genetic screening studies in yeast suggest the potential for FTase to prenylate sequences of the form -C(x)3X, with four amino acids downstream of the cysteine residue to be prenylated. The work herein begins to define the sequence scope for this …
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The responses of cellular proteins to cisplatin-damaged DNA
… that at least some of the consequences of this genetic damage are mediated by proteins that bind to the cisplatin-DNA cross-links or influence cellular pathways in response to the genotoxic stress. In either case, such factors can regulate the processing of the cisplatin lesions and thereby …
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I. Isolation and Characterization of Bioactive Compounds From Suriname and Madagascar flora. II. A Synthetic Approach to Lucilactaene
As part of an International Cooperative Biodiversity Group (ICBG), extracts of plants from Suriname and Madagascar were bioassayed for cytotoxicity and antimalarial activity. Six cytotoxic extracts and one potential antimalarial were selected for fractionation, and yielded a number of bioactive …