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Showing 1 to 1 of 1 for “"p53, osterix, bone, c-Abl, DNA, damage"”.
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Roles for C-ABL and P53 in bone homeostasis and DNA damage response
We identified p53, a well known tumor suppressor, as a novel regulator of bone remodeling. p53-/- mice display a high bone mass phenotype, an overall result of enhanced bone formation and increased bone resorption. p53 negatively regulates osteoblast differentiation and osteoblast-dependent …