Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 665 for “"p53"”.
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p53 nuclear localization control, and p53-dependent regulation of DNA repair gene transcripts
… cells of mice with a deletion allele for the Trp53 gene, to explore both the regulation of p53, and its downstream functions mediated by specific activation of target genes. Chapter 2 addresses the regulation of nuclear localization of the p53 protein. Previous reports in the literature had …
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Evaluating The Therapeutic Efficacy of Restoring Wild-Type P53 Activity In P53-Mutant Tumors
<p>The p53 transcription factor is the most frequently altered in human cancers usually via missense mutations that undermine its transcriptional activity. Clinically, <em>TP53</em> mutations have been shown to be remarkably predictive of refractoriness to treatment, resulting in poor outcome. …
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p53 activity during adenovirus infection
… können und somit das Tumorwachstum fördern. p53 ist einer der wichtigsten Tumorsuppressoren in der Zelle, welcher die zelluläre genomische Integrität aufrecht erhält. Die p53 Funktion ist in den meisten humanen Tumoren gestört. Dabei haben u.a. DNA Tumorviren verschiedenste Wege entwickelt, …
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Discovering the p53 isoforms’ code
p53 has a key role in the maintenance of the genetic stability and, thus, in preventing tumour development. The current model is that the p53-dependent responses are solely driven by p53α. The uncovering that the TP53 gene physiologically expresses several p53 isoforms, challenges this paradigm. …
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Targeting mutant p53 in cSCCs
… patients with multiple cSCCs.<br/><br/>Wild-type p53 (wt-p53) has been shown to prevent cSCC development and induce tanning and sunburn responses in skin cells. However, TP53 mutations are found in over half of all human cancers and cSCC is no exception as TP53 mutational frequency in cSCCs is …
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p14ARF : A p53-Independent Tumor Suppressor
… begun to be defined. Its interaction with the p53 pathway, which is estimated to be inactivated or mutated in 50% of all cancers, makes it difficult to determine its own independent effects, but also makes it a prime target for cancer intervention. Taken together, one or both of these pathways …
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An investigation of mutant p53 function.
The TP53 tumour suppressor gene is mutated in approximately 50% of all human cancers. The majority of these mutations are missense mutations resulting in the expression of a mutated form of the full-length p53 protein. This mutant protein exhibits a loss of tumour suppressive activity, …
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Characterisation and Detection of P53 Aggregates
P53 is a tumour-suppressing protein whose primary function is to protect the integrity of the genome, specifically by regulating DNA repair, cell cycle arrest, cell proliferation, and apoptosis. Wild-type (WT) p53 has multiple aggregation-prone regions and can form amyloid aggregates. Some mutants …
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Epitranscriptional Control of the Caspase-2—MDM2—p53 Axis: The Role of the m6A Writer in p53 Signaling.
… lesions and advanced malignancies. The p53 tumor suppressor pathway, acting through the Caspase-2–MDM2–p53 signaling axis, provides a crucial surveillance mechanism that detects centrosome aberrations and prevents the propagation of genomically unstable cells. Despite significant …
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Cooperative Tumor Suppression by ARF and p53
… proliferation. Two tumor suppressor genes, p53 and Arf, play important roles in protecting cells against numerous biological stresses. In response to oncogenic signals, increased ARF expression leads to the activation of p53, which in turn leads to the cessation of cell division or induction …
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P53 Genes Act to Restrain Mobile Elements
Oncogenic stress provokes tumor suppression by p53 but the extent to which this regulatory axis is conserved remains unknown. Using a biosensor to visualize p53 action, we find that Drosophila p53 is selectively active in gonadal stem cells after exposure to stressors that destabilize the genome. …
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Dissecting The Interaction Between P53 and Trim24
<p>Dissecting the Interaction of p53 and TRIM24</p> <p>Aundrietta DeVan Duncan</p> <p>Supervisory Professor, Michelle Barton, Ph.D.</p> <p>p53, the “guardian of the genome”, plays an important role in multiple biological processes including cell cycle, angiogenesis, DNA repair and apoptosis. …
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Targeting the p53/MDM2 protein-protein interaction
The p53/MDM2 protein-protein interaction is the most widely characterised proteinprotein interaction to date. As of 2014, there are over 20 compounds that have been shown to the p53-MDM2 protein-protein interaction, however many compounds have not progressed into clinical trials due to their high …
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Elucidating p53’s physiological and tumourigenic roles
The key role of p53 as a tumour suppressor is widely acknowledged and based on many observations that p53 suppresses oncogene-mediated transformation of rodent fibroblasts and is the most frequently mutated gene in human cancers. However, the p53 family of transcription factors is evolutionarily …
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Functionality of mutant p53 in early tumorigenesis
TP53, encoding a stress-activated transcription factor, is commonly mutated in human cancers. Most of these mutations are missense mutations which, in the presence of WT-p53 (p53mut/+), can cause loss of function (LOF), dominant-negative (DN) and/or gain of function (GOF) activities. However, …
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