Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"p38MAPK"”.
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Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence
… signaler p38 mitogen-activated protein kinase (p38MAPK) activation and fetal membrane senescence are associated with parturition. Our study determined changes in multipotent pro-cell cycle regulator glycogen synthase kinase (GSK) 3β and its regulation by p38MAPK in effecting senescence to …
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Rol de la p38MAPK en la activación de plaquetas y células endoteliales mediada por los anticuerpos antifosfolípidos
… significativamente cuando se inhibe la p38MAPk con el inhibidor especifico SB20380.
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Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL)
… induced phosphorylation of ZAP70/Syk, ERK, p38MAPK, and AKT in R-CLL cells whilst CD180-mediated signalling in NR CLL cells did not progress downstream from ZAP70/Syk phosphorylation indicating a block in activation of downstream protein kinases, and possible anergy. However, the responses …
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Regulation and inhibition of pro-tumorigenic microenvironments
… regulatory network composed of p38MAPK and the RNA-binding protein AUF1, which regulates SASP mRNA stability and sustains SASP expression after the induction of senescence. Finally, I have demonstrated that p38MAPK is a viable stromal-specific therapeutic target for the …
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CD180/RP105 Toll-like Receptor (TLR) mediated signalling in Chronic Lymphocytic Leukaemia
… induced phosphorylation of ZAP70/Syk, ERK, p38MAPK, and AKT. In contrast, CD180-mediated signalling in NR CLL cells did not progress downstream from ZAP70/Syk phosphorylation indicating a block in activation of downstream protein kinases, and possible anergy. To further clarify the …
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Cross-modulatory Actions of Cell Cycle Machinery on Estrogen Receptor-alpha Level and Transcriptional Activity in Breast Cancer Cells
… degradation of ERα upon activation by p38MAPK. Interestingly, this regulation of ERα by sequential actions of p38MAPK and Skp2 that was observed specifically during the G1/S transition and S-phases of the cells cycle was found to be critical for the progression of cells through S-phase. …
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The expression and signalling patterns of CD180 toll like receptor in Chronic Lymphocytic Leukaemia (CLL)
… through mitogen-activated protein kinase (p38MAPK). However, little is known about the function of the other BCR - sIgD in CLL and its possible interaction with CD180. Here we studied intracellular signalling and apoptosis of CLL cells following sole or sequential ligation of CD180 and …
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The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… moleculae inhibitor of its upstream regulator p38MAPK with a chemical inhibitor enhanced <em>GLS2</em> mRNA expression and mitochondrial metabolism. Moreover, we demonstrate that <em>GLS2</em> over-expression alone increases mitochondrial metabolism, reduces the glycolytic metabolic program, …
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The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors
… (SRF) in a p38 mitogen-activated protein kinase (p38MAPK) dependent manner. Knockdown of SRF by siRNA or inhibition of p38MAPK reduced the expression of CYLD and increased cell proliferation rate. These results suggest that SRF is a positive regulator of CYLD expression, which in turn reduces the …
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The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
… migration and phosphorylation of ERK-1/2 and p38MAPK. PANC-1 cells also contained functional S1P1 and S1P2 receptors that inhibited proliferation. Overall, a pharmacological approach demonstrated that S1P receptors regulate cancer cell proliferation, migration and signal pathways in a …
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The effects of HIV-1 viral protein r (vpr) and anti-retroviral drugs in the brain: Implications in HIV-1 associated neurocognitive disorders
… plasmid. Also, the involvements of PI3K-Akt and p38MAPK pathways as well as the transcription factor NF-κB, C/EBP and AP-1 were determined in Vpr-mediated induction of IL-6 and IL-8 by utilization of chemical inhibitors and siRNAs. In additional experiments, the translocation of NF-κB subunit p65 …
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The effects of training organisation on the physiological, metabolic and molecular responses to a soccer-specified laboratory based training simulation
… change in the phosphorylation of AMPK and p38MAPK. This would suggest that the global effect of soccer-specific intermittent exercise on aerobic performance may be partly mediated by adaptations associated with mitochondrial biogenesis in skeletal muscle. ' In Chapter 6, the effect of prior …
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Effects of phosphatidylinositol on ApoA-I metabolism: Implications in HDL metabolism
… to various MAP kinase inhibitors. While the p38MAPK inhibitor SB203580 has no effect on PI-induced apoA-I secretion, the MEK1/2 inhibitor U0126 blocks PI-induced apoA-I secretion. Inhibition of the JNK MAPK pathway by SP600125 also blocks PI mediated apoA-I secretion. Real-time PCR shows no …
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The Effect of Stress Induced Premature Senescence on the Expression of Heterogeneous RibonucleoIeoprotein
… senescence and possibly independent of p38MAPK.</p>
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Cardiac hypertrophy and the dynamic changes in structure and function after pressure overload
… that, following aortic banding, the γ isoform of p38MAPK translocates into the nucleus during the progression of cardiac hypertrophy, suggesting that this isoform of p38 may be involved in the synthesis of proteins involved in pathological remodelling (Dingar et al, 2010). Hypothesis: It was …
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Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
… potent induction of reactive oxygen species and p38MAPK phosphorylation. These findings illustrate the heterogeneous manifestations of senescence-like growth arrest and elucidate the distinctive biology and oncogenic properies of RUNX1 and its fusion derivatives.
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… optic atrophy-1 (OPA1), with the inhibition of p38MAPK in high glucose attenuating this effect. Conclusion Hyperglycaemia induced pyknotic-like phenomenon, suppressed the proliferation, and reduced mitochondrial fusion protein machinery of mESC-derived cardiac-like cells. These effects were …
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Regulation of Human Renal Drug Transporters by Inflammatory Cytokines and Pregnancy-related Hormones in Primary Proximal Tubular Epithelial Cells
… activity. Mechanistic experiments with ERK, p38MAPK, JNK, and NF-κB inhibitors demonstrated that IL-1β suppresses OAT1/3 via JNK, OAT2 via p38MAPK, and induces OCTN1 via NF-κB. IL-6 classic and trans-signaling did not reproduce IL-1β-driven changes in transporter mRNA, despite IL-6 being a …
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Role of Transient Receptor Potential (TRP) Channels in Nociception
… HEK cells, suggesting the involvement of STZ-ROS-p38MAPK pathway. TRPV4 has been reported to be involved in vasodilatation by shear stress in blood vessels. Here, I have demonstrated that TRPV4 is expressed in lymphatic endothelial cells (LECs). Treatment with low concentration of H2O2 enhanced …
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