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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 22 for “"p38 mitogen-activated protein kinase"”.

  1. Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase

    Greinier, Amy

    … demonstrated that a rise in intracellular pH activated apoptotic proteins leading to cytochrome C release. This "apoptotic alkalinization" occurred upon activation of the plasma membrane protein, sodium hydrogen exchanger-1 (NHE1), whose activity is regulated by the stress kinase p38 MAPK. In …

    ucf

  2. Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.

    Mortimer, Heather JaneUniversity of Glasgow2010

    … have been identified in the bone morphogenetic protein receptor II gene (BMPRII) (chromosome 2q32-31) a member of the Transforming Growth Factor  (TGF) (Lane et al, 2000). Despite the mutation being present in all cells, vascular wall remodelling is only seen in the pulmonary circulation with …

    glasgow Repository record

  3. Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells

    Waldman, Lynne KMassachusetts Institute of Technology2010

    … A growing body of literature links loss of p38 mitogen-activated protein kinase (MAPK) activity with the promotion of Ras-induced transformation in murine cells. Accordingly, I examined the effect of inhibiting p38 in normal human cells in which I also activated a low level of oncogenic Ras …

    mit Repository record

  4. Genetic analysis of p38 mitogen-activated protein kinase signaling in innate immunity and stress physiology of Caenorhabditis elegans

    Pagano, Daniel J. (Daniel Joseph)Massachusetts Institute of Technology2014

    … of multicellular organisms is the stress-activated p38 mitogen-activated protein kinase (MAPK) pathway. This thesis focuses on the physiological role of p38 MAPK signaling in the host defense of Caenorhabditis elegans. In Chapter Two, I report the identification and characterization of the …

    mit Repository record

  5. On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy

    Röme, AndradaDepartment of Clinical Sciences, Lund University2010

    … of P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (CD162) abolished radiation-provoked leukocyte and platelet rolling in the colon. Moreover, inhibition of P-selectin and P-selectin glycoprotein ligand-1 also markedly decreased firm adhesion of leukocyte and platelets, suggesting …

    lund Repository record

  6. Functional role of GSK3β in p38MAPK mediated human amnion membrane senescence

    Lavu, NarmadaThe University of Texas Medical Branch at Galveston2021

    Oxidative stress (OS) induced stress signaler p38 mitogen-activated protein kinase (p38MAPK) activation and fetal membrane senescence are associated with parturition. Our study determined changes in multipotent pro-cell cycle regulator glycogen synthase kinase (GSK) 3β and its regulation by p38MAPK …

    utmb Repository record

  7. Modulating Bone morphogenetic protein (BMP) and Transforming growth factor-beta (TGF-β) signalling with green tea catechins in mammalian cells

    Nganwuchu, Chinyere C.University of Bradford2025

    … activity, reduce the phosphorylation of SMAD3 proteins, and decrease the expression of pai-1 transcript. These green tea catechin compounds also decreased the BMP4-induced phosphorylation of p38 mitogen-activated protein kinase proteins and promoted BMP4-induced SMAD-dependent by increasing the …

    bradford Repository record

  8. Cellular and Molecular Mechanisms Involved in the Induction of the Lipostatic Cytokine Leptin by Tumor Necrosis Factor Alpha

    Finck, Brian NealUniversity of Illinois at Urbana-Champaign2015

    … and mortality of chronic disease. Leptin is a protein hormone secreted by adipocytes that has been identified as a blood-borne factor inherently linking feeding behavior and metabolism to the individual's nutritional state. The studies detailed herein examine hyperleptinemia elicited by tumor …

    uiuc Repository record

  9. Maintenance of fetal membrane integrity by cyclic cellular transitions during gestation and parturition

    Richardson, Lauren SThe University of Texas Medical Branch at Galveston2022

    … transforming growth factor beta 1 (TGF-β), TGF-β activated kinase binding protein (TAB1), and p38 mitogen-activated protein kinase (p38 MAPK) signaling in human and mice membranes. This process is balanced during gestation by progesterone (P4) which transitions ‘reservoir’ stromal AMCs into …

    utmb Repository record

  10. Effect of Anti-fibrotic Drug (Pirfenidone) on TGF-β Signaling Pathway in Ocular Fibrotic Disorders

    이, 기황2015

    … assay. Immunoblot analyses of cofilin, Smad protein (Smad) 2/3, p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and extracellular signal related kinase expression were conducted to elucidate the cell signaling networks that contribute to the anti-fibrotic effect of pirfenidone. …

    ajou Repository record

  11. Targeting Myeloid Protein Kinase C Signaling to Overcome Immune Suppression and Improve Immunotherapy in Cancer

    Chaib, Mehdi2023

    … we first investigated the effect of protein kinase C (PKC) agonist PEP005 on MDSC expansion, differentiation, and recruitment to the tumor microenvironment. We found that PKC agonists decreased MDSC expansion from the bone marrow and induced MDSC differentiation to an APC-like …

    tenn-hsc Repository record

  12. Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling

    NGUYEN, THI NGOC TU2012

    … by the type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family members, was necessary for TLR4 signaling. However, details of the PIP5K-mediated PIP2 production pathway and its direct regulatory effect on TLR4 signaling remain not well understood. Thus, in the present study, I have …

    ajou Repository record

  13. Microvascular endothelial response to cocaethylene exposure: morphological and molecular observations

    Danyel Hermes TackerThe University of Texas Medical Branch2004

    … inositol 1,4,5 trisphosphate, and phosphorylated p38 mitogen-activated protein kinase concentrations, as well as changes in DNA binding activity and dimer composition of nuclear factor-kappaB (Aim Four). The observed changes suggest a distinct alteration of endothelial cell and monolayer function …

    utmb Repository record

  14. Characterization and Reversal of Doxorubicin-Mediated Changes In Sensory Neurons

    Coughlin, Brittany L, <p>orcid.org/0000-0002-0796-1512</p>2018

    … activation of extracellular signal-regulated kinase (ERK), consisting of an immediate and a delayed phase of activation, and to transient activation of p38 mitogen-activated protein kinase (p38 MAPK) in <em>Aplysia</em> sensory neurons. These two MAPKs have competing roles in the induction of …

    uthsc Repository record

  15. Roles of CCAAT/enhancer-binding protein [beta] and [-delta] in immunoglobulin G immune complex-induced Inflammation

    Yan, Chunguang

    <p>CCAAT/enhancer-binding protein (C/EBP) &beta and C/EBP&delta are known to participate in the regulation of many genes associated with inflammation. However, little is known about the activation and function of C/EBP&beta and -&delta in inflammatory responses elicited by Fc&gamma receptor …

    nodak Repository record

  16. 조골세포 사멸 및 분화에서 GSK3b의 역할

    윤, 선일2011

    … osteoblasts through the GC receptor. Dex activated GSK3β, and inhibition of GSK3β by lithium, a pharmacological antagonist, or gene knock-down by siRNA prevented the Dex-induced apoptosis. Unexpectedly, Dex also activated p38 mitogen-activated protein kinase (p38 MAPK); however, the …

    ajou Repository record

  17. The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors

    Ahlqvist, KristoferMolecular tumor Pathology2012

    … factor serum response factor (SRF) in a p38 mitogen-activated protein kinase (p38MAPK) dependent manner. Knockdown of SRF by siRNA or inhibition of p38MAPK reduced the expression of CYLD and increased cell proliferation rate. These results suggest that SRF is a positive regulator of CYLD …

    lund Repository record

  18. Role of the Plasma Membrane Calcium ATPase as a Negative Regulator of Angiogenesis

    Baggott, Rhiannon RebeccaUniversity of Wolverhampton2014

    … in the regulation of angiogenesis such as p38 mitogen-activated protein kinase (MAPK), phosphatidylinositol-3 kinase (PI3K), extracellular signal-related kinase 1/2 (Erk1/2) and of particular interest the calcineurin/nuclear factor of activated T-cell (NFAT) pathway. Inhibition of …

    wlv Repository record

  19. Blood plasma-mediated effects on regenerative features of a novel adult human cardiac stem cell population

    Höving, AnnaUniversität Bielefeld

    … and the upregulation of genes associated to the p38 mitogen-activated protein kinase (p38-MAPK)-pathway. Pharmacological inhibition of p38-MAPK significantly reduced the beneficial effects of human blood serum in terms of decreased proliferation and migration as well as increased senescence. Next …

    bielefeld Repository record

  20. Mechanisms of soy isoflavones in the regulation of vascular function

    Si, HongweiVirginia Tech2007

    … soy products, enhanced the expression of eNOS protein and subsequently elevated nitric oxie (NO) synthesis in both HAECs and human umbilical vein endothelial cells, concomitant with the increased eNOS mRNA expression (2.6-fold of control) and eNOS promoter activity, suggesting that genistein …

    vt Repository record

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