Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"p38 MAPK"”.
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p38 MAPK Signalling in Endothelial Apoptosis
… The main objective was to elucidate the role of p38 mitogen activated kinase (p38) in such systems, using the endothelial cell line EA.hy926. We found that p38 plays an important proapoptotic role in both, TNF- and doxorubicin-induced apoptosis. In TNF-induced cell death, p38 mediates …
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Untersuchungen zur Beteiligung von p38 MAPK beim Remodelingprozeß nach Myokardinfarkt in vivo und bei der Fibronektinexpression in Rahmen der Neointima - Entstehung nach Angioplastie in vitro
… Arbeit wurden Untersuchungen zur Beteiligung von p38 MAPK beim Remodeling-Prozeß nach Myokardinfarkt in vivo und bei der Fibronektin-Expression in Rahmen der Neointima- Entstehung nach Angioplastie in vitro durchgeführt. Im Bereich der kardiovaskulären Forschung hat die Familie der Mitogen …
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Targeting pro-inflammatory mediators to treat visceral pain
… is mediated by TRPV1 signalling and p38 MAPK activity respectively, downstream of TNFR1 receptor activation. I therefore sought to investigate whether TNFR1-evoked p38 MAPK activity is also involved in TNFα sensitisation of colonic afferent responses to capsaicin and noxious …
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Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
… that the stress mitogen activated protein kinase p38 MAPK is consistently activated in PAFB exposed to acute hypoxia, and is constitutively upregulated in PAFB cultured from rats exposed to chronic hypoxia (Welsh et al, 1998; Welsh et al; 2001). This response to hypoxic exposure has been shown to …
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Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
… rates for subsets of mRNAs. Both the Erk1/2 and p38 MAPK pathways activate Mnk1 meaning that Mnk1 responds to growth signals through Erk1/2 and stress signals through p38 MAPK. However, it is not clear how Mnk1 mediates translational changes specific to each pathway. We investigated the …
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Genetic analysis of p38 mitogen-activated protein kinase signaling in innate immunity and stress physiology of Caenorhabditis elegans
… multicellular organisms is the stress-activated p38 mitogen-activated protein kinase (MAPK) pathway. This thesis focuses on the physiological role of p38 MAPK signaling in the host defense of Caenorhabditis elegans. In Chapter Two, I report the identification and characterization of the conserved …
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Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase
… whose activity is regulated by the stress kinase p38 MAPK. In previous studies, upon cytokine withdrawal from cytokine-dependent lymphocytes induced the activity of the p38 MAP kinase which then phosphorylated the C-terminus of NHE1. To identify the p38 MAPK phosphorylation sites on NHE1, in vitro …
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Modeling Brk/PTK6 expression in the mammary epithelium.
… mediators downstream of Brk, including STAT5 and p38 MAPK were activated relative to wild-type mice. Brk-mediated signaling to STAT5 and p38 MAPK was recapitulated with Brk expression in non-transformed HC11 murine mammary epithelial cells. Additionally, non-transformed HMEC and HC11 cells …
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Examining Altered NF-κB Signalling Following 1,4- Benzoquinone Exposure in HD3 Cells
… with the signalling pathway involving NF-κB, p38-MAPK and c-Myb. The objectives were to determine if ROS and p38-MAPK mediate benzoquinone (BQ) induced changes in NF-κB activity, and if downstream targets of NF-κB are altered after BQ exposure. HD3 chicken erythroblast cells were transfected …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… such as the mitogen-activated protein kinase (MAPK). Although there are several different MAPKs, the p38 MAPKs are involved in cardiogenesis and implicated in stimulating myocyte apoptosis, hypertrophy, or even antiapoptotic effects. As such, the role of p38 MAPKs in diabetic cardiac …
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The cardioprotective mechanisms of dietary flavonoids
… quercetin pre-treatment on ERK1/2, PKB, JNK and p38 MAPK phosphorylation was monitored using western blotting. It was shown that quercetin was the most potent flavonoid at inducing a protective effect, and 3’-O-methylquercetin the most potent metabolite. Using western blotting it was shown that …
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Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
… fibroblasts. It is known that suppression of p38 MAPK activity in WS fibroblasts can reverse the senescence and promotes cell proliferation. As increased IGFBP-3 expression is associated with cellular senescence, and suppression of p38 MAPK can reverse senescence in WS fibroblasts, it is …
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The impact of diabetes on cardiac remodelling after myocardial infarction: potential role of thyroid hormone signalling
… stretch-induced kinase hypertrophic signalling p38 MAPK. In contrast, ERK, p-ERK and p-p38 MAPK levels were not changed in DM+AMI as compared to non-infarcted hearts (DM+SHAM). TH administration after AMI prevented hypothyroidism and resulted in decreased β-MHC expression, increased wall …
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The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling
… sulfate proteoglycans. Using inhibitors to p38 MAPK and ERK, we showed that activation of both of these pathways was essential for load-induced heparan sulfate production, TGF-,f1 activation, smad-2 activation and increased FGF-2 uptake. Further, we exposed cells to strain in the presence of …
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Identifikation des mitochondrialen Proteins Frataxin als stoffwechselmodulierenden Tumorsuppressor
… Proteine (geringere Phosphorylierungsrate p38-MAPK, vermehrte Expression HSP-25, verminderte Expression HSP-70) aufgezeigt werden. Im inversen Ansatz wurde eine Steigerung des mitochondrialen Energiestoffwechsels durch stabile transgene Frataxinüberexpression in zwei Kolonkarzinomzelllinien …
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The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling
… SPARC-GFP increases migration and activation of p38 MAPK and HSP27 signaling compared to GFP control cells. Deletion of the Acidic Domain increases cell adhesion and reduces SPARC-induced migration and p38 MAPK/HSP27 signaling. The EGF-like Module Deletion mutant decreases SPARC-induces migration …
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Characterisation of Anti-Apoptotic Signalling Pathways in Hepatocytes activated by alpha-Lipoic Acid and Atrial Natriuretic Peptide
… of rat livers leads to a marked activation of p38 MAPK. Since ANP reduces apoptotic cell death, the potential connection between this ANP-induced p38 MAPK activation and apoptosis reduction was investigated. Astonishingly, liver perfusion with an p38 MAPK inhibitor even decreased apoptotic cell …
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Identifizierung von Signaltransduktionskomponenten des Latenten Membranproteins 1 des Epstein-Barr Virus
… spezifisches Signalmolekül für die Induktion von p38 MAPK durch LMP1 auf einem MKK6-abhängigen Signalweg identifiziert werden. In TRAF6 defizienten Maus-Fibroblasten ist eine signifikante p38 MAPK-Aktivierung durch LMP1 von der ektopischen Expression von TRAF6 abhängig. Darüber hinaus ist TRAF6 …
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