Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"p38 MAP kinase"”.
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Angiotensin II-induced Apoptosis in Vascular Smooth Muscle Cells: Differential Effects in Human Saphenous Vein and Human Internal Mammary Artery
… Protein expression of Bax, Bcl-2, and phospho-p38 MAP kinase was examined by Western Blot. The data revealed three major findings: (1) Angiotensin II induced significant apoptosis in VSMCs of the SV following 8 hours of treatment, whereas there was no pro- apoptotic effect of angiotensin II on …
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The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… specific and dependant on phosphorylation of p38 mitogen-activated protein (MAP) kinase, the cell signalling pathway(s)underlying this are incompletely characterised. Hypoxic activation of PAFs is a potential therapeutic target but, as p38 MAP kinase inhibitors are not established for clinical …
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Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase
… whose activity is regulated by the stress kinase p38 MAPK. In previous studies, upon cytokine withdrawal from cytokine-dependent lymphocytes induced the activity of the p38 MAP kinase which then phosphorylated the C-terminus of NHE1. To identify the p38 MAPK phosphorylation sites on NHE1, …
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Sevofluran hemmt die DNA-Bindung des Transkriptionsfaktors Aktivator Protein-1 und induziert Apoptose in T-Lymphozyten
… <br>auf die Aktivität der AP-1-regulierenden MAP-Kinasen ERK, JNK und p38 <br>konnte im Western Blot nicht nachgewiesen werden. Desfluran und Isofluran <br>beeinflussten die DNA-Bindung von AP-1 nicht. Inkubation mit Sevofluran führte <br>zu geringer Hemmung der DNA-Bindung von NFAT und …
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Expression of Human Estrogen Receptor and Studies of Estrogen-Mediated Transcription and Apoptosis
… transfections and a reporter system to measure p38 activity, we show that E2 induces the p38 activity 12--36 fold in several ER positive cell lines, while OHT induces p38 activity 2--5 fold. A selective inhibitor of p38 MAP kinase, S13 203580, partially protects HeLa-ER5 cells against apoptosis …
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Regulation of mRNA expression through 3’ UTR sequences of IL6 gene in amino acid-deprived HeLa cells
… of p65, NF-κB subunit. Finally, treatments of p38 MAP kinase inhibitor, SB203580 markedly blocked mRNA stabilization through 3’UTR as well as IL6 induction after amino acid-starvation, suggesting that p38-MK2/3-TTP pathway is evidently activated and implicated in stabilization of IL6 mRNA …
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Expression und Regulation des antimikrobiellen Cathelicidin-Peptids LL-37 in humanen Kolonepithelzellen, Monozyten und PBMC
… zu beeinträchtigen. Bei einer Blockade des p38/MAP-Kinase Weges stellte es sich genau andersherum dar: Die Differenzierung wurde gehemmt, aber die LL-37 Expression wurde nicht beeinflusst. Somit wird die LL-37 mRNA Transkription in Kolonepithelzellen über den MEK/ERK Signalweg und die …
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HIV Tat Protein Activates Endothelial Cells through NFκB and MAP Kinase Pathways.
… TNFα). Cell lysate fractions were analyzed for MAP Kinase activity and NFκB activation, and culture supernatants were assayed for inflammatory cytokines (IL-6 and IL-8). The production of IL-6 and IL-8 was significantly enhanced by tat but not by gp120. Both gp120 and tat, however, induced …
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Influences of nutrition and pathogenicity from a microbial diet on immunity and longevity in Caenorhabditis elegans
… response to pathogenic bacteria downstream of p38 MAP Kinase signaling. In Chapter Four, I present ideas for exploring the future directions of these two projects that focus on untangling how C. elegans respond to a changing microbial environment.
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TNFalpha expression in monocytes/macrophages
… product LPS or direct activators of protein kinases) which induce TNF production in cells of the monocytic lineage. The main focus has been to study the signal transduction pathway regulating TNF expression. Dexamethasone, a synthetic glucocorticoid, inhibits bacteria-induced TNF production …
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Untersuchungen zur Signaltransduktion des CXCR4 (CD 184) Chemokinrezeptors im Hinblick auf Vitalität und Migration humaner B-CLL-Zellen
… wurde die Beteiligung der Phosphatidylinositol-3-Kinase (PI-3-K) und der Mitogen-Activated Protein Kinasen (MAPK): p44/42 (ERK1/2) und p38 im Signaltransduktionsweg des CXCR4-Rezeptors untersucht. <br>Es wurde nachgewiesen, dass PI-3-Kinase und p38 MAP-Kinase für die SDF-1 vermittelte Chemotaxis …
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Biochemical investigation of phosphodiesterase type IV post-translational modification, cellular localisation and interaction with associated binding proteins
… compartmentalised through binding of PDEs to A-kinase anchoring proteins (AKAPs) that scaffold PKA regulatory subunits. In this study post-translational-modification of PDE4 isoforms is investigated. SUMOylation is a relatively newly identified post-translational modification that is known to …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
… TREM-2 expression through phosphoinositide 3-kinase (PI3K) and PI3K/ p38 MAP kinase signalling pathways respectively. TGF-β1-induced TREM-2 also required extracellular signal-regulated kinase 1/2 post-translationally for protein expression. Interestingly, TREM-2 was required for TGF-β1-induced …
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Interventions against obesity through increased lipolysis in adipose tissue
… lipolytic signalling pathway, including protein kinase A and p38 MAP kinase. In addition, M2 and mazindol were capable of increasing glucose uptake into insulin sensitive tissues. M2 and mazindol can act directly on adipose tissue and skeletal muscle to increase glucose uptake via a pathway …
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Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… both NMDAR-induced nuclear translocation of the p38 MAP kinase and activation of the transcription factor MEF2C. These data demonstrate that GluN3A negatively regulates NMDAR-dependent activation of gene transcription and reveal a novel mechanism that regulates the level of NMDAR-induced …
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Characterisation of novel compounds as antagonists of protease-activated receptor-2 (PAR2)
… Ca2+ and downstream cascades including ERK MAP kinase mediate an array of cellular effects stimulated through PAR2. Many studies have demonstrated the involvement of PAR2 in a number of disease pathologies including arthritis, GI disorders and inflammatory pain. However, treatments for these …
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The anti-cancer activity of a novel palladacycle, BTC2, in oestrogen receptor positive and triple negative breast cancers
… The results indicated that BTC2 activated the p38 MAP kinase signalling pathway and the p53 response in MCF7 cells. It is worth noting that MDA-MB-231 cells have a mutant p53 but that the p53 target protein, p21, was upregulated in both MCF7 and MDA-MB-231 cells. This suggests that p21 is …
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A Systems Level Analysis of the Transcription Factor FoxN2/3 and FGF Signal Transduction in Sea Urchin Larval Skeleton Development and Body Axis Formation
… this ectopic expression of nodal requires active p38 MAP kinase. The loss of oral restriction of nodal expression results in the abnormal organization of PMCs and the larval skeleton; it also induces ectopic expression of oral-specific genes and represses aboral-specific genes. The abnormal …
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Stochastic processes in T-cell signaling
… of RasGRP and SOS in the activation of ERK and P38 MAP kinase pathways. We extended established computational models developed in our lab and predicted that SOS' allosteric pocket is important for the magnitude and bimodal pattern of ERK activation, which was confirmed experimentally. The …
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