Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 299 for “"p38"”.
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p38 MAPK Signalling in Endothelial Apoptosis
… The main objective was to elucidate the role of p38 mitogen activated kinase (p38) in such systems, using the endothelial cell line EA.hy926. We found that p38 plays an important proapoptotic role in both, TNF- and doxorubicin-induced apoptosis. In TNF-induced cell death, p38 mediates …
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Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
… rates for subsets of mRNAs. Both the Erk1/2 and p38 MAPK pathways activate Mnk1 meaning that Mnk1 responds to growth signals through Erk1/2 and stress signals through p38 MAPK. However, it is not clear how Mnk1 mediates translational changes specific to each pathway. We investigated the …
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Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
… This work aimed at assessing the role of p38, a mitogen-activated protein kinase (MAPK), in the potential of PGE2 to trigger cellular proliferation, transcription and expression of proliferative (Cyclin D1) and inflammatory (IL-6) mediators in a human epithelial oesophageal cell line …
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Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase
… whose activity is regulated by the stress kinase p38 MAPK. In previous studies, upon cytokine withdrawal from cytokine-dependent lymphocytes induced the activity of the p38 MAP kinase which then phosphorylated the C-terminus of NHE1. To identify the p38 MAPK phosphorylation sites on NHE1, in vitro …
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Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
… that the stress mitogen activated protein kinase p38 MAPK is consistently activated in PAFB exposed to acute hypoxia, and is constitutively upregulated in PAFB cultured from rats exposed to chronic hypoxia (Welsh et al, 1998; Welsh et al; 2001). This response to hypoxic exposure has been shown to …
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Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells
… A growing body of literature links loss of p38 mitogen-activated protein kinase (MAPK) activity with the promotion of Ras-induced transformation in murine cells. Accordingly, I examined the effect of inhibiting p38 in normal human cells in which I also activated a low level of oncogenic Ras …
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Genetic analysis of p38 mitogen-activated protein kinase signaling in innate immunity and stress physiology of Caenorhabditis elegans
… multicellular organisms is the stress-activated p38 mitogen-activated protein kinase (MAPK) pathway. This thesis focuses on the physiological role of p38 MAPK signaling in the host defense of Caenorhabditis elegans. In Chapter Two, I report the identification and characterization of the conserved …
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Παθοβιοχημεία της εκφύλισης μηνίσκου στον άνθρωπο : συμμετοχή του σηματοδοτικού άξονα p38 MARK-NF-kB και της Κυκλο-οξυγενάσης 2 (COX-2)
… μελέτη εξετάστηκε ανοσοϊστοχημικά η έκφραση της p38 MAPKινάσης, της ενεργού φωσφορυλιομένης μορφής της p-p38, του στόχου NF-kB (με τα διμερή p50-p65) καθώς και της COX-2 σε μηνισκικές ρήξεις, και διερευνήθηκε η συμμετοχή τους στην ανάπτυξη εκφύλισης. Τα ευρήματα απέδειξαν αυξημένη έκφραση του …
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Untersuchungen zur Beteiligung von p38 MAPK beim Remodelingprozeß nach Myokardinfarkt in vivo und bei der Fibronektinexpression in Rahmen der Neointima - Entstehung nach Angioplastie in vitro
… Arbeit wurden Untersuchungen zur Beteiligung von p38 MAPK beim Remodeling-Prozeß nach Myokardinfarkt in vivo und bei der Fibronektin-Expression in Rahmen der Neointima- Entstehung nach Angioplastie in vitro durchgeführt. Im Bereich der kardiovaskulären Forschung hat die Familie der Mitogen …
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Expression of Human Estrogen Receptor and Studies of Estrogen-Mediated Transcription and Apoptosis
… transfections and a reporter system to measure p38 activity, we show that E2 induces the p38 activity 12--36 fold in several ER positive cell lines, while OHT induces p38 activity 2--5 fold. A selective inhibitor of p38 MAP kinase, S13 203580, partially protects HeLa-ER5 cells against apoptosis …
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Label Transfer Reagents for the Investigation of Protein Kinase Complexes
… The mitogen-activated protein kinase (MAPK) p38 is involved in multiple pathways, and its regulation depends on its interactions with other signaling proteins. However, the weak and transient nature of these interactions makes the identification of p38 interacting proteins challenging. For …
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Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
… fibroblasts. It is known that suppression of p38 MAPK activity in WS fibroblasts can reverse the senescence and promotes cell proliferation. As increased IGFBP-3 expression is associated with cellular senescence, and suppression of p38 MAPK can reverse senescence in WS fibroblasts, it is …
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Targeting pro-inflammatory mediators to treat visceral pain
… is mediated by TRPV1 signalling and p38 MAPK activity respectively, downstream of TNFR1 receptor activation. I therefore sought to investigate whether TNFR1-evoked p38 MAPK activity is also involved in TNFα sensitisation of colonic afferent responses to capsaicin and noxious …
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A study on the role of oxidative stress and protein kinase signalling in hyperglycaemia induced cardiac remodelling
… Although there are several different MAPKs, the p38 MAPKs are involved in cardiogenesis and implicated in stimulating myocyte apoptosis, hypertrophy, or even antiapoptotic effects. As such, the role of p38 MAPKs in diabetic cardiac remodelling, especially during cardiac development, remains …
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Molecular Regulation of Opioid Receptor Signaling
… rKOR, pentazocine was more potent at activating p38 MAPK in hKOR than rKOR expressed in HEK293 cells. In contrast, pentazocine was equally potent for arrestin-independent activation of ERK1/2 in hKOR and rKOR. There were no potency differences between hKOR and rKOR in U50,488 activation of ERK1/2 …
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Modeling Brk/PTK6 expression in the mammary epithelium.
… mediators downstream of Brk, including STAT5 and p38 MAPK were activated relative to wild-type mice. Brk-mediated signaling to STAT5 and p38 MAPK was recapitulated with Brk expression in non-transformed HC11 murine mammary epithelial cells. Additionally, non-transformed HMEC and HC11 cells …
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