Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"p35"”.
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Regulation of Phosphorylation of PPARγ by CDK5 in Obesity
… (CDK5) which requires a non-cyclin partner (p35) for activity was proposed to phosphorylate Ser273, while obesity promoted cleavage of p35 to p25 thereby enhancing CDK5 phosphorylation of PPAR? (Choi et al 2010). However the sequence surrounding Ser273 is not a CDK5 consensus, therefore I …
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Baculovirus inhibitors of apoptosis
… was detected from 24 hours post infection. The p35-deficient mutant of AcMNPV (Acp351acZ) induces apoptosis in Spodopterafrugiperda (Sf21) cells, but not in Richoplusia ni (T. nil cells. In complementation assays with Acp351acZ in MI. cells, both OpMNPV iap and CpGV iap are capable of …
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Role of Talin1 Phosphorylation In Beta1 Integrin Activation and Prostate Cancer Metastasis
… correlates with expression of its activator p35, and is responsible for talin1 phosphorylation and β1 integrin activation.</p> <p>Next, I demonstrated that talin1 phosphorylation is required for Prostate cancer bone metastasis <em>in vivo</em>. In the metastatic PC3-MM2 cells, expression of a …
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Low Temperature Induced Signaling and Molecular Responses in Tomato
… A diurnal and circadian regulated protein (p35) was purified and its full length cDNA sequence (named dcr) was cloned. Chilling treatment delays the endogenous rhythm of dcr transcripts and that may also associate with interfering specific protein phosphorylation states.
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Development of the adolescent prefrontal cortex and basolateral amygdala and the effects of puberty and alcohol exposure
… dendrites and dendritic spines between P20 and P35 (prepuberty) in both sexes as well as both structures. After P35, the dendrites of the mPFC were shown to prune predominately in females, whereas in the BLA,dendrites slightly increased in length but significantly increased in the number of …
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Effects of oral delta-9-tetrahydrocannibinol (THC) administration on motor activity and anxiety-like behavior in adolescent and adult Sprague-Dawley rats of both sexes
… (3.0, 5.0, and 10.0 mg/kg) starting on either P35-37 for adolescent-onset groups or P79-81 for adult-onset groups 90 min prior to each behavioral test. Our data suggests that THC induced a dose-dependent decrease in locomotor activity in the OFA. Additionally, drug-treated animals differed in …
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Relationship between construction waste generation and recycling practices in Southern Johor
… unused sack bags as pots to grow small plants (P35). Therefore, timber is the highest recycled material in the construction site compared to metal, concrete and packaging materials. This study provides awareness to contractors and government authorities if recycling being practiced at …
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Die Funktion des spaghetti-Gens in Drosophila melanogaster
… durch ektopische Expression des Baculovirus p35-anti-apoptotischen Faktors verhindert werden. Das Spaghetti-Protein ist predominant in den Embryonen nachweisbar. Western-Blot Analysen von Kernextrakt sowie Immunfluoreszenzaufnahmen von Kernen der Embryonen zeigen, dass das Spaghetti-Protein …
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
… 5 (Cdk5) is activated by its regulatory subunit, p35, to post-translationally modify substrates through phosphorylation. In this thesis, I provide several lines of evidence that Cdk5 plays a critical role in synaptic function and plasticity. First, we characterized the function of Cdk5 in learning …
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Investigations into Building Block Structure and Method of Preparation on the Properties of Nanomaterials
… along with a nuleating peptide, AG-P35, as a co-template: Chapter 5). Various morphologies of silver nanoparticles were obtained and it's found that the morphology was highly dependent on polymer and peptide concentrations and incubation time. Micelles from a novel hyperbranched …
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Molecular modeling and SAR studies of CDK5/p25 selective inhibitors
… biochemical process the CDK5-natural activator, p35 is cleaved by calpain to a shorter protein p25, which in turn hyperphosphorylates Tau, forms neurofibrillary tangles and causes AD. CDK5 deregulation is also indicated in other neurodegenerative diseases, such as Huntington's chorea, stroke, …
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… partners – including the adaptor protein p35 and the polarity protein PAR6. Finally, I have shown that inhibition of a pathway involving the Rho-associated coiled-coil containing protein kinase (ROCK) reverts circularisation induced by a1- chimaerin, and that a blocking peptide based on …
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Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis
… complexity, truncation of the Cdk5 cofactor, p35 is thought to increase the catalytic ability of the Cdk5 complex and alter its substrate specificity profile, although little evidence has been provided to support this claim. <br/><br/>In the present study, in vitro peptide analysis was …
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Diverse roles of cyclooxygenase in the central nervous system and the periphery
… prone to KA-induced seizures than the adult (P35). The seizure activities in the adult, which were aggravated by COX inhibition, showed less than those in the neonate. However, the neonatal seizure was not affected by COX inhibition which caused by little COX activity. Interestingly, in the …
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Plant-derived Murine IL-12 and Ricin B-Murine IL-12 Fusions
… encoded, disulfide-linked subunits of IL-12 (p35 and p40), a single-chain form of mouse IL-12 (mIL-12) was utilized. Hairy root cultures, as a fast-growing bioproduction system were developed from high expressers of mIL-12. A purification scheme was developed to purify plant-derived mIL-12 …
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The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
… the pleiotropic chemokine CXCL10, but not IL12-p35 or iNOS, as a specific target. </p> <p>We then attempted to understand the role of IRF1 and CXCL10 in mucosal innate protection against infections in vivo. Flagellin augmented the P. aeruginosa-induced expression of CXCL10 in CECs in WT, but not …
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Fertilidad del suelo en tres sistemas de manejo en café (Coffea arabica L.) y su efecto en el rendimiento, Masatepe - Masaya
El objetivo de este estudio fue comparar la influencia de tres sistemas de manejo en café sobre la fertilidad física, química y biológica del suelo y el rendimiento en café oro en el municipio de Masatepe, departamento de Masaya, Nicaragua en el período de julio del 2009 a enero del 2010. El …
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Proceso de erosion de suelo en cuatro sistemas de cobertura vegetal en el municipio de Boaco, 2006
El área experimental está ubicada en el departamento de Boaco, municipio de Boaco a 88 Km. de la capital. Su posición geográfica se ubica entre los 12º 27 ́ 57.3 ́ ́ de latitud norte y los 85º39 ́47.5 ́ ́ de longitud oeste, el tipo de suelo según su orden se clasifica en molisol, con pendientes …
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Evaluación del proceso de erosión en laderas bajo diferente sistema de cobertura vegetal en el municipio de Boaco 2008
El proceso de erosión es uno de los procesos de degradación de suelos más importantes en muchos países. En Nicaragua ha sido estudiado sistemáticamente en los últimos años en el departamento de Boaco, municipio de Boaco mediante el uso de parcelas de escurrimiento. Las parcelas se encontraron …
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Estudio de la fertilidad y la dinámica del carbono en el suelo bajo diferentes manejos agronómicos en un cafetal de cuatro años de plantado en el Pacífico de Nicaragua
Se llevó a cabo un estudio en 2004, en el centro Jardín Botánico de UNICAFE (11º54’ N y 98º09’ W) y en el Centro Experimental de Campos Azules del INTA (11º53’59” N y 83º08’59” W), Masaya, Nicaragua. Se utilizó un diseño de bloques completos al azar con 2 repeticiones en Jardín Botánico y una en …
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