Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"p300/CBP"”.
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Molecular mechanisms of Kruppel-like Factor 4
… domain of KLF4 recruits the co-activator p300/CBP to the promoter of the positively-regulated gene IAP, resulting in increased histone acetylation. On the negatively regulated gene, Cyclin B1, I demonstrate that KLF4 recruits HDAC3, decreasing histone acetylation. In addition, I show that …
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… including transcription coactivators. The p300 protein and its close paralogue CREB-binding protein (CREBBP, aka CBP) are well-known transcriptional coactivators that have intrinsic lysine acetyltransferase activity. The functions of p300/CBP largely rely on their capabilities to bind to …
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E2F1 induction following DNA damage and oncogene activation
… cellular protein complexes including the p300/CBP transcriptional activator and p400/TRRAP chromatin-remodeling complex. The results presented here illustrate novel mechanisms of E2F1 induction both by oncogenes and chemotherapeutic drugs. Two minimal domains of E2F1 are described that are …
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HTLV-1 bZIP FACTOR ACTIVATES MYOFERLIN EXPRESSION TO FACILITATE HTLV-1 INFECTION AND MIGRATION OF INFECTED T-CELLS
… (c-Jun and JunB) and recruits the coactivator p300/CBP to enhancer sites within the MYOF gene, thereby activating its expression. Consequently, MyoF expression is elevated in HTLV-1-infected T-cell lines and in CD4+ T-cells from HTLV-1 infected individuals, including those with ATL and HAM/TSP. …
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Molecular pathways controlling DNA damage response
… as p53 cofactor and a key component of the p300/CBP (CREBB binding protein) complex. TTC5 enhances the interaction of JMY (Junction mediating and regulatory protein, p53 co- factor) and P300, leading to increase in HAT (Histone acetyltransferase) activity of P300, increase in p53 …
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TARGETING THE DNA DAMAGE RESPONSE PATHWAY FOR THE TREATMENT OF AGGRESSIVE THYROID CANCERS, IN VITRO STUDIES
… while IHH- 4, characterized by alterations in p300/CBP complex regulating p53 function, showed low sensitivity to LENV, and FRO, lacking p53 expression, displayed resistance to LENV. Therefore, we sought to further investigate in vitro the DNA damage response (DDR) pathway, where p53 plays a …
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Control of Regulatory Element Function by Histone H3.3
… H3.3 KO ESCs show reduced promoter enrichment of p300- a transcriptional coactivator responsible for H3 acetylation at lysine 27 (H3K27ac). Consequently, H3.3 KO ESCs show reduced H3K27ac at promoters, along with reduced enrichment of the acetyllysine reader BRD4. Despite the enrichment of H3.3 at …
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Studies into the receptor-mediated induction of hypoxia inducible factor 1α.
… recruitment of transcription co-factors such as p300/CBP. Results presented in this thesis, which characterise ligand-activated auto-phosphorylation of insulin and IGF1 receptors (IR and IGFRI) clearly indicated that these cells possess functional insulin and IGF receptor signalling pathways. …
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Molekularbiologische Untersuchung intrazellulärer Signalwege, die in T-Lymphozyten zur Aktivierung des Transkriptionsfaktors NF-ATc führen
… NF-ATc über die transkriptionellen Koaktivatoren CBP und p300 entfalten, die an die N-terminale transaktivierende Domäne TAD-A von NF-ATc binden und dessen Aktivität kontrollieren. Der Nachweis, daß konstitutiv aktive Mutanten von c-Raf und Rac synergistisch die CBP/p300-vermittelte …