Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"p27Kip1"”.
-
Expression des Zellzyklus-Inhibitors p27 KIP1 in Leiomyomen und Leiomyosarkomen
… undertaken to examine the involvement of a cdkI p27KIP1 leiomyoma and leiomyosarcoma. Immunohistochemical staining was performed on 41 samples of leiomyoma and 35 samples of leiomyosarcoma and expression of p27KIP1 was evaluated semiquantitatively. The results were very inconsistent in both …
-
Probing the Role of Nascent Helicity in Protein Function: p27kip1 as a Regulator of the Cell Cycle
<p>p27<sup>kip1</sup> binds to and regulates the activity of cyclin-dependent kinases (Cdks) which are the master timekeepers of the cell division cycle. Members of the p27 family of proteins, also including p21 and p57, are called cyclin-dependent kinase inhibitors (CKIs). The amino terminal …
-
The Effect of Endothelin-1 on the expression of CDK Inhibitors p21 & p27 in Bovine Corneal Endothelial Cells
… cyclin dependant kinase inhibitors (p21cip1 and p27kip1) levels by Endothelin-1 (ET-1), would overcome the G1 phase arrest and promote cell cycle progression and proliferation in cultured BCECs (Bovine corneal endothelial cells). BCECs were isolated from bovine corneas and cultured in DMEM …
-
Untersuchungen zur Expression der zellzyklusassoziierten Proteine p27Kip1 und Ki-67 und der Matrixmetalloproteinaseinhibitoren TIMP-1, TIMP-2 und TIMP-3 in häufigen humanen Karzinomen
… des "extracellular signaling network" dar. p27Kip1 gehört zur Familie der cyclin-abhängigen Proteinkinase-Inhibitoren und bewirkt einen Stopp des Zellzyklus in der G1-Phase. p27Kip1 gilt als Tumor-suppressor-Gen. In humanen Tumoren ist p27Kip1 häufig reduziert, was mit einer schlechteren …
-
The Role of LIM Kinase 1 and its Substrates in Cell Cycle Progression
… of LIMK1 resulted in altered expression of p27Kip1, the G1 phase Cyclin D1/Cdk4 inhibitor. Overexpression of LIMK1 resulted in lower levels of p27Kip1 and p27Kip1-pY88 (inactive p27Kip1). Knockdown of LIMK1 resulted in elevated levels of p27Kip1 and p27Kip1-pY88. Together, these results …
-
Μελέτη ρυθμιστών του κυτταρικού κύκλου και παραγόντων που εμπλέκονται στη διεργασία αποδόμησης των P21cip1 και P27kip1 σε λεμφώματα Β-κυτταρικής αρχής. Συσχέτιση με κλινικές παραμέτρους
Κατά τη διάρκεια του κυτταρικού κύκλου ένας από τους σημαντικότερους μηχανισμούς ρύθμισης της ομοιόστασης των πρωτεϊνικών μορίων είναι η ελεγχόμενη στο χώρο και στο χρόνο αποδόμηση τους. Οποιαδήποτε ανωμαλία στη ρύθμιση των μηχανισμών αποδόμησης των πρωτεϊνών μπορεί να προκαλέσει σημαντική βλάβη …
-
The role of conexin 43 in murine sertoli cell development
… by some of the cell cycle proteins namely, p27Kip1, p21Cip1 and SKP2 (also known as CDKN1B, CDKN1A and p45, respectively). Roles of these cell cycle regulators on Sertoli cell development have been studied and Sertoli cell numbers were significantly altered in the absence of one or more of …
-
Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
… of the cyclin-dependent kinase inhibitor P27KIP1. Also, we found that the CCN5-induced PI3K-AKT inactivation leads to stabilization and nuclear accumulation of P27KIP1 resulting in cell cycle arrest of TNBC cells. Next, we have shown that CCN5 protein can induce expression of estrogen …
-
Identification and Characterisation of New Mouse Models for Hearing Loss
… arise from aberrant control of proliferation via p27KIP1. Expression of MAP3K1 is present in a number of inner ear cell types (inner and outer hair cells, spiral ganglion and stria vascularis), and investigation of targets downstream of MAP3K1 identified increased p38 phosphorylation in these …
-
Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control
… Implicated pathways include RB-E2F, p53, p27Kip1, FoxOs, p300, and the Cyclins, with additional evidence indicating a role for the Pin1 prolyl isomerase in mediating PreA regulation of the cell cycle.</p>
-
Combination of Compounds A2CE and C18 for Cochlear Hair Cell Regeneration in Adult Mice
… mice. A2CE is a transcriptional inhibitor of p27kip1, which has been shown to have a non-canonical role in suppressing a cofactor for Atoh1, which is an upstream of POU4F3 and is an important developmental gene in hair cell development. We gave transtympanic injections of our drug cocktails to …
-
Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies
… and proteasome substrates such as IκBα and p27kip1. Additionally, when nicardipine, another P-gp inhibitor, was combined with bortezomib or carfilzomib, enhanced inhibition of MDA-MB-231 cell proliferation was observed. These findings indicate that P-gp inhibitors could sensitize TNBC cells …
-
THE ROLE OF NOTCH SIGNALING IN THE DIFFERENTIAL ABILITY OF SUPPORTING CELL SUBTYPES TO SPONTANEOUSLY REGENERATE HAIR CELLS IN THE NEONATAL MOUSE COCHLEA
… of downregulating the cell cycle inhibitor, p27Kip1, after HC damage. Therefore we investigated the ability of SC subtypes to mitotically regenerate HCs by including a mitotic tracer along with fate-mapping. A larger proportion of mitotically regenerated HCs came from pillar and Deiters’ …
-
Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
… p21Waf1 protein were decreased, while those of p27Kip1 were unchanged in response to retinoic acid. The p21Waf1 mRNA expression levels were transiently increased at early time points (6-18hours), but were unchanged at later time points. In another cell line, p21Waf1 mRNA expression increased …
-
Investigation of T cell signalling events regulating immunity and tolerance in vivo
… of ERK activation and upregulation of p27kip1 might not be sufficient for maintenance of the anergic state, as indicated by G1 arrest, and hence, one or more additional negative signals may be required. Indeed, this study suggests that perhaps such a negative signal could be provided by …