Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"p22"”.
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The P22 Xis Protein: Regulation of Bacteriophage P22 Site -Specific Recombination
Mutants of P22 Xis were isolated and assayed for excision system in vivo, to quantify their excision activity relative to wild-type Xis. Mutants S18F, R19A, G29S, G29D, A33P, R35C, D37G, S43F, S43P, P44L, L46F, A51T, and A51V were found to be defective in stimulating excision. Additionally, …
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P22 arc--energetics and cooperativity of DNA binding
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1994.
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P22 arc repressor : cooperative DNA binding and transcriptional regulation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Genetic identification of phage P22 antigens and their structural location.
Thesis. 1977. Ph.D.--Massachusetts Institute of Technology. Dept. of Biology.
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Functions of scaffolding protein in phage P22 capsid assembly and maturation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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Bedeutung eines hydrophoben Seitenkettenstapels für Stabilität, Faltung und Struktur des P22 Tailspikeproteins
… homotrimere Tailspikeadhäsin des Bakteriophagen P22 ist ein etabliertes Modellsystem, dessen Faltung, Assemblierung und Stabilität in vivo und in vitro umfassend charakterisiert ist. Das zentrale Strukturmotiv des Proteins ist eine parallele beta-Helix mit 13 Windungen, die von einer N‑terminalen …
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Genetic and physical studies of bacteriophage P22 genomes containing translocatable drug resistance elements.
Thesis. 1977. Ph.D.--Massachusetts Institute of Technology. Dept. of Biology.
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Tales of Seduction and Betrayal: Host Genes Required for Assault of Salmonella by Bacteriophage P22
… encoded by Salmonella typhimurium that phage P22 requires for completion of its life cycle, especially at the step where phage DNA is translocated across the cytoplasmic membrane into the cell. Bacteria with mutations in any of these host factors required by the phage would gain resistance to …
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The role of buried stack residues in the folding of the beta-helix domain of P22 tailspike
… systematic mutational studies using the complete P22 tailspike protein, which contains a 13 rung [beta]-helix domain. The in vivo folding and assembly of 150 single mutant polypeptide chains were characterized at multiple temperatures by SDS-PAGE, which distinguishes the fully native, …
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Zelluläre Regulation von Leben und Tod durch Todeseffektordomänen (DED)-enthaltende Proteine: CAP3, c-FLIP R und p22-FLIP
… zwei neue c-FLIP-Proteine gefunden: c-FLIPR und p22-FLIP. C-FLIPR wurde als eine neue kurze c-FLIP-Spleißvariante identifiziert, während p22-FLIP ein bisher unbekanntes Spaltprodukt von c-FLIP darstellt. C-FLIPR ist in verschiedenen T- und B-Zelllinien sowie in primären humanen T-Zellen …
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Biological Functions of Intracellular Hepatitis B e Antigen
… reported as the preCore protein intermediate (p22) without the N-terminal signal peptide, remains elusive. Here, we propose to elucidate the translocation of p22 during its formation from endoplasmic reticulum (ER) to cytosol, how it differs from core in its inability to form a capsid and the …
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Biophysical chemistry of lipopolysaccharide specific bacteriophages
… One of these examples is bacteriophage P22 that binds and infects three distinct Salmonella enterica (S.) hosts. It recognizes and depolymerizes repetitive carbohydrate structures of O antigen in its host´s outer membrane lipopolysaccharide molecule. This is mediated by tailspikes, …
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Dysregulation of Immune Function, Gut Microbiota Composition and Short-Chain Fatty Acid Production Following Prenatal Alcohol Exposure: A Developmental Perspective
… at three postnatal (P) timepoints: P8 (infancy), P22 (weaning), and P38 (adolescence). Male PAE rats had increased cytokine levels in the amygdala and hypothalamus (but not prefrontal cortex) at P8. However, this pattern of neuroinflammation was not seen in the PAE females. While the effect of PAE …
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A Genetic Analysis of the Salmonella Typhi Host Range
… of S. typhimurium-S. typhi constructed by P22-mediated transduction remain unable to expand the host range of S. typhi to include mice. However, construction of genetic hybrids is useful for identifying linkage discontinuities between these species that are undetectable by other techniques.
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DNA and Ligand Binding and Kinetic Properties of Wild-Type and Mutant RsrI [n6-Adenine] DNA Methyltransferases
… in vivo was performed using the bacteriophage P22-based challenge-phage assay. I isolated a catalytically impaired mutant, M•RsrI (L72P), that, unlike wild-type M•RsrI, binds in a methylation-sensitive, site-specific manner to DNA.
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Protein and viral partitioning in two-phase aqueous micellar systems
… and the tailspikes/capsids of bacteriophage P22 (model virus). These possible attractive interactions were investigated because they could counter the effect of the excluded-volume interactions. However, the attractive interactions between the bacteriophage P22 particles and the C10E4 …
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Konservierte Struktur bei genetischer Mosaizität : die Tailspike Proteine dreier Phagen der Familie Podviridae
Die Tailspike Proteine (TSP) der Bakteriophagen P22, Sf6 und HK620 dienen der Erkennung von Kohlenhydratstrukturen auf ihren gram-negativen Wirtsbakterien und zeigen, von den ersten 110 Aminosäuren des N-Terminus abgesehen, keine Sequenzübereinstimmung. Mit Röntgenkristallstrukturanalyse konnte …
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Structure determination of bacteriophage [phi]21 N-peptide and boxB RNA complex by NMR spectrocsopy
… resistant transcription complex. The [delta], P22 and [phi]21 phage N proteins share a conserved amino-terminal, arginine-rich region, which confers phage-specific binding to boxB hairpins within the phage nut site RNA. To facilitate nuclear magnetic resonance (NMR) spectroscopy studies of the …
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High-throughput evaluation of protein folding conditions and expression constructs for structural genomics
… zur Faltung eines humanen Proteins, der p22 Untereinheit von Dynactin, welche in E. coli in Inclusion Bodies exprimiert wird. So wie es sich bei vielen Proteinen darstellt, war auch für p22 Dynactin kein biologischer Nachweistest vorhanden, um den Erfolg des Faltungsexperimentes zu …
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Developmental Monoamine Signaling Impacts Adult Affective and Aggressive Behaviors
… transporter) blockade during peri-adolescence (P22-P41) increases adult aggressive behavior. 5-HTT blockade from P2-P21 or P22-P41 reduces adult aggressive behavior. Altered aggression correlates positively with locomotor response to amphetamine challenge in adulthood and striatal dopamine and …
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