Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"p21WAF1"”.
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Translocations of Actin to Nucleus and p21WAF1 to Cytoplasm after Treatment of HDF Cells with H2O2
… 것으로 알려져 있는 cyclin-dependent kinase inhibitor인 p21WAF1의 발현정도와 세포 내 위치에 대해 젊은 세포와 노화가 진행되는 세포에서 H2O2에 대한 반응성의 차이를 조사하였다. 재료 및 방법 : 어린 남아의 포피로부터 분리한 human diploid fibroblast에 H2O2를 200 µM의 농도로 한 번 또는 반복적으로 처리하였다. 세포주기는 propidium iodide로 DNA를 염색하여 fluorescence activated cell sorting (FACS)을 통해서 …
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Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
… repress the cyclin-dependent kinase inhibitor p21WAF1, which has a role in a myriad of processes including cell cycle arrest, senescence, apoptosis, differentiation and DNA replication and repair. The current study therefore aimed to explore this possibility and to reveal a mechanism by which …
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Molecular cell cycle mechanisms of human prostate crcinoma insensitivity to TGF-β?
… (20 to 80 pM) or time of exposure (1-5 days). P21WAF1/Cip1/Sdi1 and p15INK4B but not p27K1P1 were detectable by Western blotting in normal and tumor cells. TGF-β1 treatment increased the association of p21WAF1/Cip1/Sdi1 with the Cdk2/cyclin E complex in both normal and prostate tumor cells. …
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Regulation of DNA (Cytosine-5) Methyltransferase 1 in the cell cycle and its role(s) in doxorubicin-mediated micronuclei formation
… expression level is inversely correlated with p21WAF1 protein, but the exact mechanism remained unresolved. Interestingly, I identified p21WAF1 as a novel upstream regulator of DNMT1 expression in mammalian cell lines. p300, which serves as a crucial transcription co-activator for DNMT1, …
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Modulation von Zellzyklus- und Apoptoseregulation in humanen kolorektalen Karzinomzellen durch Butyrat und Acetylsalicylsäure
… die Wirkung von Butyrat auf die Expression von p21Waf1/Cip1 und cdk2: Acetylsalicylsäure und Butyrat in höheren Konzentrationen reduzierten die Expression von cdk2 in HT-29 Zellen, in niedrigen Konzentrationen führte nur die Acetylsalicylsäure-Butyrat-Kombination zu einem Abfall des …
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Characterisation of oncogenic pathways driving the pathogenesis of prostate cancer
… PC3 cells, with upregulation of CST6, NDRG1 and p21WAF1, reducing viability and migration. TBX2 shRNA stable lines were also successfully generated with results mirroring siRNA depletion. Ch-IP qPCR assays confirmed TBX2 binds the promoters of CST6, E-cadherin, NDRG1 and p21WAF1 in PC3 …
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The roles of DNA(cytosine-5) methyltransferase1 in carcinogenesis related to cellular factors, virus and chemicals
… and hence protecting the complex from attack by p21Waf1/Cip1.
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Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
… cells. In one cell line levels of the CDKI, p21Waf1 protein were decreased, while those of p27Kip1 were unchanged in response to retinoic acid. The p21Waf1 mRNA expression levels were transiently increased at early time points (6-18hours), but were unchanged at later time points. In another …
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The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
… to examine the role of the cell cycle regulator, p21WAF1/CIP1 in GC-induced growth retardation. Finally, the growth plate sparing effects of a novel GC receptor modulator, AL-438, have also been identified. AL438, has reduced effects on bone growth compared to Dex, but maintains similar …
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Structural Studies of DNA Replication Proteins by X-Ray Crystallography and Molecular Dynamics
… clamp in complex with a peptide derived from p21WAF1/CIP1 a DNA replication inhibitor, from a resolution of 2.6 Å to a resolution of 2.3 Å.</p>
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Overcoming radioresistance by targeting p21 in cancer
… kinase inhibitor p21 (CDKN1A), also known as p21WAF1/Cip1, is the main p53 transcriptional target and it is traditionally recognized as a tumor suppressor since it is involved in genomic stability preservation, cell cycle arrest or senescence induction, and DNA repair. Here we show that …
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Evaluation of novel prognostic factors In ovarian carcinoma
… gene abnormalities in p53, p16INK4A, RB-1, p21WAF1/CIP1, Cyclin D1, Erb-B2, and MSH2. Adverse outcome was also examined in addition to survival and RFS, to identify novel molecular prognostic markers. P53 overexpression in 44 of 112 (39%) was associated with reduced survival and RFS (' p' = …
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Ruolo dell'Enantiomero (R)-9-HSA nel controllo della proliferazione in una linea di Adenocarcinoma del Colon umano
… phase mediated by a direct activation of the p21WAF1 gene, bypassing p53. We have previously shown that 9-HSA controls cell growth and differentiation by inhibiting histone deacetylase 1 (HDAC1) activity, showing interesting features as a new anticancer drug. The interaction of 9-HSA with the …
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Protective Effects of Milk Phospholipids Against UV-Induced DNA Damage in Human Skin Cells
… marker, cyclin-dependent kinase inhibitor, p21WAF1/CIP1. Western blots were used to quantify p21 expression in human keratinocytes in four categories of samples: No-UV, UV, UV+MP, MP and in HeLa (p21 positive control). In the No-UV samples, cells were not irradiated by UV light. However, in …
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CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS
… of the cyclin-dependent kinase inhibitor p21Waf1. But this up-regulation was not observed in TGFβ-resistant ones. We examined the possibility that LPA-induced p21 might contribute to the cytostatic response to TGFβ. Indeed, TGFβ alone induced p21 expression weakly in TGFβ-sensitive cells. …
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Stress and Growth Related Keratinocyte Pathways
… cell cycle control proteins, such as p53, p21Waf1, c-myc and related proteins. This suggests that IEX-1 is another crucial element in the pattern of regulatory pathways of cell growth and defense against malignant transformation.
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Die Hämatopoetische Progenitor Kinase (HPK) 1 und NFAT-Transkriptionsfaktoren unterstützen die Apoptose von T-Lymphozyten
… Weitere von den NFAT´s kontrollierte Gene sind p21WAF1, der CD40L und der CD95L. Somit scheinen die NFAT´s bei der Zellzyklus-Kontrolle und beim AICD von T-Lymphozyten eine wichtige Rolle zu spielen. Daten unseres Labors zeigten, dass die T-Zell-Aktivierung zu einer massiven Induktion der kurzen …