Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"p21-activated kinase"”.
-
P21- ACTIVATED KINASE 4 AND ACTIN CYTOSKELETON DYNAMICS
P21-ACTIVATED KINASE 4 (PAK4), A SERINE/THREONINE KINASE FROM THE GROUP II PAK FAMILY KINASES, IS ONE OF MANY ACTIN DYNAMICS REGULATORS THAT CONTROL THE FORMATION OF ACTIN-RICH STRUCTURES SUCH AS FILOPODIA IN MAMMALIAN CELLS. PAK4 PHOSPHORYLATES LIM KINASE (LIMK), WHICH IN TURN, PHOSPHORYLATES THE …
-
Characterizing the role of p21-Activated Kinase 3 (PAK3) in AP-1-induced transformation
Previous studies identified p21-Activated Kinase 3 (PAK3), a serine/threonine kinase, as a potential AP-1 target gene. PAK3 has been implicated in a variety of pathological disorders and over-expression of other PAK-family members has been linked to cancer. In this study, we investigated AP-1 …
-
Role of Xenopus p21-activated kinase 2 (X-PAK2) in polar body formation during oocyte maturation
… event: de novo synthesis of a protein kinase termed pEg3. Prophase oocytes contain low levels of pEg3 protein. De novo synthesis of pEg3 protein is evident during oocyte maturation. (Abstract shortened by UMI.)
-
<i>Dictyostelium discoideum</i> Protein Kinase C-orthologue <i>pkcA</i> Regulates the Actin Cytoskeleton through Interaction with Phospholipase D and p21-activated Kinase
… of a fruiting body. pkcA, a putative Protein Kinase C-orthologue, has previously been shown to regulate development and fruiting body formation. Here we show that pkcA is involved in cell density sensing, chemotactic signaling, cell morphology, and cell-cell cohesion. Additionally, we show …
-
Regulation of Myosin V-Cargo Interactions by Phosphorylation
… filaments in many cell types. Two independent kinases, Calcium/calmodulin-dependent kinase II (CaMKII) and p21-activated kinase-1 (PAK1), are able to phosphorylate the globular tail of myosin V. Mutation analysis and mass spectrometry were used to determine the actual site of phosphorylation …
-
Genetic analysis of novel regulators of neuronal migration in Caenorhabditis elegans: the insulin/IGF-1 signaling pathway, a chromatin-binding factor ZFP-1 (AF10) and endogenous RNAi
… HSN migration. Furthermore, I identify PAK-1, a p21-activated kinase, as a downstream target of DAF-16 in the hypodermis. This study is the first to demonstrate a non-autonomous role for both FOXO and Pak1 in neuronal migration. I also implicate a conserved PHD zinc finger protein ZFP-1/AF10 and …
-
The Structural and Functional Study of GIT1 Paxillin Binding Domain
<p>The G protein coupled receptor (GPCR)-kinase (GRK) interacting protein 1 (GIT1) is a multidomain protein that plays an important role in cell adhesion, motility, cytoskeletal remodeling, and membrane trafficking. GIT1 mediates the localization of p21-activated kinase (PAK) and PAK-interactive …
-
Rescue of Fragile X Syndrome phenotypes in Fmr1 KO mice by the small molecule PAK inhibitor FRAX486
… modulation of actin cytoskeleton dynamics: p21-activated kinase (PAK). In a healthy brain, PAK and FMRP - the protein product of fmr1 - antagonize one another to regulate spine number and shape. Inhibition of PAK with a strategy utilizing mouse genetics reverses spine abnormalities as well …
-
Bacterial Manipulation of Actin Dynamics via p21 Activated Kinases and Cofilin
… major reported negative regulator of cofilin is p21 activated kinase 1 (PAK1). These dynamic structures and the importance of actin turnover result in targets for manipulation by bacterial pathogens, such as Salmonella Typhimurium’s ability to enter non-phagocytic cells, and Shigella flexneri to …
-
Analysis of signal transduction pathways and the cytoskeleton in VASP-deficient cell lines and mouse models
… a substrate for cGMP- and cAMP-dependent protein kinases (cGKs and cAKs). Ena/VASP proteins are involved in Actin-filament formation, plasma membrane protrusion, acceleration of Actin-based motility of Listeria and the establishment of cell-cell adhesion. Moreover, Ena/VASP proteins have been …
-
Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta
… with different isoforms of the protein kinase CK1 (formerly known as Casein Kinase 1) family via the DUF1669 domain. It is believed that FAM83 proteins may act as subcellular anchors and key regulators of CK1 isoforms. CK1 is thought to be a constitutively active serine/threonine protein …
-
Molekulare und funktionelle Analyse der p21-aktivierten Kinase Mbt (mushroom bodies tiny) in der Augen- und Pilzkörperentwicklung von Drosophila melanogaster
… Signalmolekül aus der Familie der p21-aktivierten Kinasen (PAK) aus Drosophila, während der Augen- und Pilzkörperentwicklung. Mbt wird aufgrund von Sequenzhomologien der PAK Unterfamilie II (PAK4-6) zugeordnet. PAK4-6 binden präferentiell die aktivierten Rho-GTPasen Cdc42 und …