Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 254 for “"p21"”.
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Overcoming radioresistance by targeting p21 in cancer
… by p53. The cyclin-dependent kinase inhibitor p21 (CDKN1A), also known as p21WAF1/Cip1, is the main p53 transcriptional target and it is traditionally recognized as a tumor suppressor since it is involved in genomic stability preservation, cell cycle arrest or senescence induction, and DNA …
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P21- ACTIVATED KINASE 4 AND ACTIN CYTOSKELETON DYNAMICS
P21-ACTIVATED KINASE 4 (PAK4), A SERINE/THREONINE KINASE FROM THE GROUP II PAK FAMILY KINASES, IS ONE OF MANY ACTIN DYNAMICS REGULATORS THAT CONTROL THE FORMATION OF ACTIN-RICH STRUCTURES SUCH AS FILOPODIA IN MAMMALIAN CELLS. PAK4 PHOSPHORYLATES LIM KINASE (LIMK), WHICH IN TURN, PHOSPHORYLATES THE …
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Role of Amplification of Chromosome 6P12-P21 in Human Osteosarcoma
… a portion of chromosome 6 between cytobands 6p12-p21. The high frequency of these particular rearrangements implies they could confer selective advantage to tumour cells during osteosarcoma development. In the present study, we examined the relationship between genomic gain of chromosome 6p12-p21, …
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Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression
… been reported that long non-coding RNA lincRNA-p21 is induced upon radiation and chemotherapy. This induction contributes to DNA-damage repair, cell death and cell cycle regulation. In this study, we focused on Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that …
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Regulation of the cyclin-dependent kinase inhibitor p21 by TBX3
… repress the cyclin-dependent kinase inhibitor p21WAF1, which has a role in a myriad of processes including cell cycle arrest, senescence, apoptosis, differentiation and DNA replication and repair. The current study therefore aimed to explore this possibility and to reveal a mechanism by which …
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Reactive Oxygen Species and P21 Waf1/Cip1 Are Both Essential For
… work shows that the p53 transcriptional target, p21, is crucial in initiating and maintaining senescence in HNSCC, through its ability to regulate reactive oxygen species (ROS). With the use of a novel system to evaluate the impact of the <em><em>TP53 </em></em>missense mutations, we were able to …
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Bacterial Manipulation of Actin Dynamics via p21 Activated Kinases and Cofilin
… major reported negative regulator of cofilin is p21 activated kinase 1 (PAK1). These dynamic structures and the importance of actin turnover result in targets for manipulation by bacterial pathogens, such as Salmonella Typhimurium’s ability to enter non-phagocytic cells, and Shigella flexneri to …
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Characterization of Fasting-Induced p21 Expression and Protection of Intestinal Stem Cells
<p>The cyclin dependent kinase inhibitor, p21, plays a key role in cell cycle. Additionally, the p21 gene, <italic>Cdkn1a</italic> (hereafter <italic>p21</italic>) is often used as a marker of cellular stress. To investigate <italic>p21</italic> promoter activity under basal conditions and in …
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Molecular Dynamics of p21 and Fluorescent Sphingomyelin in Keratinocytes Exposed to UVB
… the content and location of the damage marker p21 within keratinocytes that were incubated in sphingomyelin (SM) and later exposed to UV. Confocal microscopy and automated image processing provided the tools to assess large populations of keratinocytes in the effort to accurately identify the …
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Mechanisms of cell senescence: p21 and DNA damage response in aging and longevity
… gene linking aging to stress response is indeed p21, an induction of cyclin-dependent kinase inhibitor which triggers cell growth arrest associated with senescence and damage response and notably is involved in the up-regulation of multiple genes that have been associated with senescence or …
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E2F1 and Tumor Suppression: The Role of P21, Mirnas, and The Dna Damage Response
… might mediate its tumor suppressive properties: p21-induced senescence, miRNAs, and the DNA damage response. We found that E2F1 acts as a tumor suppressor in response to ras activation through a non-apoptotic mechanism requiring ARF and p53, but not p21. However, p21-loss inhibited two-stage …
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Characterizing the role of p21-Activated Kinase 3 (PAK3) in AP-1-induced transformation
Previous studies identified p21-Activated Kinase 3 (PAK3), a serine/threonine kinase, as a potential AP-1 target gene. PAK3 has been implicated in a variety of pathological disorders and over-expression of other PAK-family members has been linked to cancer. In this study, we investigated AP-1 …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… encodes the cyclin dependent kinase inhibitor p21. p21 halts cell-cycle progression in response to DNA damage and can also induce senescence. However, p21 expression in cancer cells undergoing chemotherapy allows survival by entering a senescent state in a process called …
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Functional characterization of the cyclin-dependent kinase inhibitor p21 by gene targeting in the mouse
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Role of Xenopus p21-activated kinase 2 (X-PAK2) in polar body formation during oocyte maturation
Vertebrate oocytes are physiologically arrested in meiotic prophase until shortly before ovulation. Under the influence of gonadotropic hormones, these oocytes resume meiosis and progress to metaphase II, in which they await fertilization. The transition from prophase to metaphase II is termed …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
… of c-Myc is the transcriptional repression of p21, this thesis examines this hypothesis by investigating the significance of the upregulation of p21 following c-Myc deletion in Apc deficient intestinal enterocytes. To do this, I have generated triple knockout (TKO) intestines by intercrossing …
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The Effect of Endothelin-1 on the expression of CDK Inhibitors p21 & p27 in Bovine Corneal Endothelial Cells
… of cyclin dependant kinase inhibitors (p21cip1 and p27kip1) levels by Endothelin-1 (ET-1), would overcome the G1 phase arrest and promote cell cycle progression and proliferation in cultured BCECs (Bovine corneal endothelial cells). BCECs were isolated from bovine corneas and cultured in …
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Multiple Levels of Regulation of Cyclin-dependent Kinase Inhibitor 1A (p21/WAF-1) by the <i>DDX5 </i>Gene
… In addition, p68 was shown to be required for p21 induction through both the recruitment of p53 and RNA pol II to the p21 promoter in response to DNA damage: Specifically, p68 was shown to be essential for the p53 dependent induction of the p21 mediated G1/S cell cycle arrest under DNA damage …
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