Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"p16"”.
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HPV and p16 in head and neck cancer
… to determine whether any correlation exists with p16 or survival. An initial pilot study of sixty formalin-fixed HNSCC was carried out in order to optimise the methodology for the PCR and immunohistochemistry. A further 84 benign lesions, 12 dysplasias and additional 80 HNSCC were also included. …
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P16/INK4a controls the morphology program associated with cellular senescence
… <br>Results: We here demonstrate that the p16 protein controls the morphological aspects of the senescence program. Inactivation of the p16 gene in senescent human cells causes the loss of the enlarged, flattened senescent phenotype, while growth arrest remains unaffected. Instead, cells …
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Stability, folding and evolution of the tumour suppressor protein p16.
The tumour suppressor protein, p16, is a member of the INK4 family of inhibitors of the cyclin D-dependent kinases 4 and 6 in the pRb pathway of eukaryotic cell cycle. The 156-amino acid protein consists of four ankyrin (ANK) repeats. The ANK repeat is a ubiquitous 33-residue sequence motif that …
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Involvement of the WT1 and p16 genes in Wilms' tumour and human malignant mesothelioma
… I have studied two such genes, the WT1 and p16 genes, which in their wild type forms are known to contribute to development of the urogenital system and the mesothelium (WTI) and to control of the cell cycle (pi6).
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Developing nanobodies to stabilise the tumour suppressor protein p16INK4a
The tumour suppressor protein p16INK4a (p16) is a cyclin-dependent kinase (CDK) inhibitor that plays a key role in the regulation of the cell cycle by controlling the progression of cells through the G1 to S phase transition. Dysregulation of the protein through deletion, silencing or mutation of …
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Study of Rest As A Negative Regulator of P16Ink4A
… OF REST AS A NEGATIVE REGULATOR OF P16<sup>INK4A</sup></strong><strong> </strong></p> <p><strong>Monica Gireud, B.S.</strong></p> <p><strong>Thesis Advisor: Vidya Gopalakrishnan, Ph.D.</strong></p> <p>The<em> RE1</em> Silencing Transcription Factor (REST) is a negative regulator of …
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The added value of BAP1 immunohistochemistry and fluorescence in situ hybridisation for CDKN2A/p16 and NF2 in the diagnosis and prognostication of pleural mesothelioma
Background: Mesothelioma is a rare but aggressive malignancy with therapeutic options that are generally palliative. The malignancy can be challenging to diagnose, commonly due to scant samples, often requiring patients to undergo multiple procedures before a definitive diagnosis can be reached. In …
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Invasion and Proliferation in Malignant Cells
… cells originate. We here specifically studied p16 and ERK1/2 with special focus on and the relation to proliferation and invasion in non-melanoma skin cancer and in breast cancer. In a model system of basal cell carcinoma, we observed that tumor cells changed phenotype from a highly …
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Valor predictivo de la sobreexpresión inmunohistoquímica de la proteína p16 (ink4a) como marcador de progresión en neoplasias uterinas cervicales escamosas intraepiteliales de bajo grado (l-sil)
… determinación inmunohistoquímica de la proteína P16, (que es una expresión indirecta de la infección viral y de la degeneración maligna) y su incorporación en ciertas etapas del cribado poblacional o tras el diagnóstico de alguna lesión pre invasora, podría mejorar estos aspectos comentados. Así, …
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Cambios epigenéticos, génicos y de expresión proteica en el cáncer de laringe. Análisis del segmento cromosómico 9P21
… implicadas en la carcinogénesis: p14, p15 y p16. Objetivos: 1. Analizar el patrón de alteraciones génicas y de metilación en diversos genes supresores de tumores, centrando nuestro estudio en CDKN2A y CDKN2B, localizados en el segmento cromosómico 9p21. 2. Analizar la expresión de las …
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Postnatale Entwicklung präsynaptischer Opioidrezeptoren im Hippocampus und Septum der Ratte
… nahm von 4 bis 16 Tagen postnatal (P4-P16) sowohl im Hippocampus als auch im Septum konstant zu. Bei P16 war in beiden Regionen das adulte Niveau noch nicht erreicht. (2) Eine aktionspotential-induzierte, exozytotische Acetylcholin-Freisetzung ließ sich im Septum und im Hippocampus …
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Juvenile pilocytic astrocytomas: A search for prognostic markers
… features and also evaluating the BRAF, p16 and protein kinase ERK components of the MAPK pathway. The findings thereof were correlated with the clinical picture to establish if these markers have any prognostic or predictive value. Materials and methods: The total number of cases …
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Perfil inmunohistoquímico de los adenocarcinomas nasosinusales de tipo intestinal y lesiones premalignas
… E-cadherina, ¿-catenina, EGFR, HER2-neu, p53, p16, ki67, COX2, TNF¿, p65 e iNOS. Estudio de los cambios histológicos observados en tejido sano adyacente al tejido tumoral y de fosa nasal contralateral y estudio IHQ a este nivel. RESULTADOS: El 97% de los pacientes eran hombres con una media de …
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The effect of maternal nutrition on offspring gene regulation via epigenetic modulation
… low-protein diet on the regulation of the p16 cell-cycle gene expression in the mammary gland of offspring rats. Timed-pregnant Sprague-Dawley rats were fed during gestation one of two isocaloric diets, control (18% casein) or low protein (LP, 9% casein). The expression of p16 mRNA in the …
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Epidemiological and molecular insights into Human Papillomavirus-related head and neck squamous cell carcinomas
… on the efficacy of existing biomarkers such as p16. This is further complicated by the absence of additional biological markers and a dearth in our understanding of the molecular mechanisms underlying HPV-driven tumourigenesis. While HPV positivity is more commonly detected in the oropharynx, …
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The Mechanism of Tumorigenesis In The Immortalized Human Pancreatic Cell Lines: Cell Culture Models of Human Pancreatic Cancer
… of K-ras (90%) and Her2 (70%), loss of p16 (95%) and p14 (40%), inactivation p53 (50-75%) and Smad4 (55%). However, the role of these signature gene alterations in PDAC is still not well understood, especially, how these genetic lesions individually or in combination contribute …
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Infección por Virus de Papiloma Humano (HPV) en carcinomas epidermoides de laringe, hipofaringe y orofaringe
… evaluados, y la expresión proteica de p16 y p53 se analizó por inmunohistoquímica. La detección del ADN de alto riesgo del HPV se realizó mediante GP5 +/6+-PCR e hibridación in situ (ISH). En los casos positivos se realizó una RT-PCR de ARNm de E6. Resultados: en OPSCC treinta casos …
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Clinicopathological and molecular characterization of gastroesophageal junction (GEJ) adenocarcinoma before age of 40 years
… specific for the locus specific regions 9p21 (p16), 20q13.2 and Y chromosome. We evaluated 663 patients with GEJ adenocarcinoma and further divided them into 2 age-groups of <or= 40 and >or= 50 years, rispectively. FISH with selected DNA probe for Y chromosome, locus 9p21 (p16), and locus …
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The epidemiology of ovine progressive pneumonia (ovine lentivirus): Diagnosis, risk factor analysis, and production effects in sheep at the United States Meat Animal Research Center
… (TM), major capsid P25, and matrix P16) were produced in E. coli and purified for use as antigen for anti-OLV antibody detection by indirect enzyme-linked immunosorbent assay (ELISA). In a comparison of recombinant TM, P25, and P16 ELISAs, a whole-virus ELISA and the agar gel …
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Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
… of the carbachol PI response from P4-P16 corresponded fairly well with the laminar distribution of [3H]quinuclidinyl benzilate binding (Fuchs, 1995). However, in the subplate layer the carbachol response was strong while receptor binding was minimal. The carbachol response decreased …
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