Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"p15INK4B"”.
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Molecular cell cycle mechanisms of human prostate crcinoma insensitivity to TGF-β?
… of exposure (1-5 days). P21WAF1/Cip1/Sdi1 and p15INK4B but not p27K1P1 were detectable by Western blotting in normal and tumor cells. TGF-β1 treatment increased the association of p21WAF1/Cip1/Sdi1 with the Cdk2/cyclin E complex in both normal and prostate tumor cells. However, there was no …
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The Role of CDCA7 in Akt-mediated Myc-Dependent Apoptosis and Proliferation
… BAX and Cyclin B1 mRNA levels while reducing p15INK4B mRNA levels. This data points to a novel mechanism which implicates Akt phosphorylation of CDCA7 as participating in the dual signal model of Myc of function and thus affecting Myc-dependent growth and transformation. In this study, we have …
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
Promoter hypermethylation mediated gene silencing is a frequent epigenetic finding in many cancers that affects genes known to have important roles in several aspects of cell biology. Hematological malignancies have been reported to harbor multiple genes aberrantly silenced by promoter …