Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"p14arf"”.
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p14ARF : A p53-Independent Tumor Suppressor
<p>Many genetic alterations at the CDKN2A locus on human chromosome 9 have been shown to be at least partially responsible for transformation of cells to a cancerous phenotype. This locus encodes two proteins, p16 and p14, that play a pivotal role in tumor surveillance.</p> <p>Breakdowns in the p14 …
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Regulation of the Tumor Suppressor ARF by TGFβ in Human Cancer Cells
Since its discovery, p14ARF (p19Arf in mice) has been shown to be an important regulator of the cell cycle, carrying out this function through p53-dependent and independent mechanisms. ARF expression has recently been shown by the Skapek lab to be induced by TGFβ in mouse embryonic fibroblast and …
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Analysis of driver gene mutations in oesophageal squamous cell carcinoma
… siRNA-mediated knockdown experiments targeting p14ARF and p16INK4a in OSCC. In silico structural analysis of missense mutations in p14ARF and p16INK4a was conducted using UCSF Chimera tool. WGS analysis identified 35 frequently mutated genes in OSCC, among these, TP53, CDKN2A.p16INK4a, …
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In-vitro- und In-situ-Analyse des Tumorsuppressorgens hp19 ARF in malignen Melanomen
Lack of hp19ARF (=p14ARF) expression or its functional inactivation has been observed in human and murine carcinomas. Although very few mutations of hp19ARF have been detected in some cancer types, changes in expression seem to play an important role in the development of other human cancers such …
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The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
… sheath keratinocytes resulted in upregulation of p14ARF and K15, suggesting EZH2 involvement in regulating proliferation and stem cell activity. Thus, this study demonstrates that PRC2-mediated repression is crucial for epidermal homeostasis and hair growth. Modulating the activities of PRC2 in …
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Delineating mechanisms which underlie differential cell fates induced by p53 activation and HDAC inhibition in colorectal cancer
… mechanisms. This includes dysregulation of the p14ARF/MDM2 axis which constitutes the major mechanism for inducing p53 stabilisation within the cell. Strategies aimed at reactivating latent wild-type p53 in such tumours therefore hold enormous clinical potential. This led to the development of …