Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"p14"”.
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Interaction of Spliceosomal U2 snRNP Protein p14 with Its Branch Site RNA Target
… protein splicing factors. One splicing factor, p14, is the only protein shown to interact directly with the branch site in the fully assembled spliceosome. In this research we have used electrophoretic mobility shift assays (EMSA) and nuclear magnetic resonance (NMR) under non-denaturing …
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p14ARF : A p53-Independent Tumor Suppressor
… This locus encodes two proteins, p16 and p14, that play a pivotal role in tumor surveillance.</p> <p>Breakdowns in the p14 pathway have been estimated to be present in approximately 40% of human cancers and only recently have its binding partners and effects begun to be defined. Its …
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Acute and Chronic Effects of Artificial Rearing on Rat Genioglossus Muscle
… gastric cannula until postnatal day 14 (P14). At P14, artificially reared (AR) rat pups were either placed with a lactating dam until the end of the weaning period and allowed to mature until postnatal day 42 (P42), or anesthetized and prepared for physiological experimentation. GG …
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Regulation of Interferon Stimulated Genes Following Enveloped Virus Entry and Delivery of Viral Nucleic Acid
… by virus-like particles or the purified protein p14 are sufficient to upregulate ISGs in the absence of viral nucleic acid. This thesis examines the mechanism by which cells recognize membrane fusion and how this affects downstream signalling and upregulation of ISGs. We found that membrane …
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Cytokine priming enables triggering of naive auto-reactive CD8[superscript +]T cells by weak agonist ligands of the TCR
… +]T cells that express transgenic P14 TCR (P14 cells), which recognizes an antigenic peptide derived from the glycoprotein antigen (GP33) of lymphocytic choriomeningitis virus (LCMV). We show that, following priming with IL-21 in the presence of IL-7 or IL-15, P14 cells gain the …
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Influence of retinal states on the development and maintenance of retinofugal projections
… retinal activity in Gβ5-/- mice at P7, P12, P14, and P28 correlates with impaired eye-specific segregation of retinal afferents in the LGN at corresponding timepoints. However, Gβ5-/- mice exhibit a normal transition from cholinergic to glutamatergic drive that corresponds with a temporary …
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Role of hnRNP A1 in the Regulation of HDM2 Gene Expression
… we also found a significant increased in both p14 mRNA and protein levels with the overexpression of GFP-A1 suggesting that p14 ARF is induced via hnRNP A1. p14 ARF has been shown to directly interact with HDM2 and induced its degradation leading to the stabilization of p53. These results …
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The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
… quanta and AMPA mEPSCs were unchanged in P14-17 calyx synapses of CaV1.3-/- deaf mice. However, synaptic strength was augmented because presynaptic action potentials were broader leading to increased quantal release, consistent with lower paired-pulse ratios and stronger depression during …
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Postnatal Maturation Modulates Cerebrovascular Myogenic Tone
… that the greater cerebral myogenic response in P14 compared to adult MCA appears due to greater pressure-induced increases in [Ca ]i, rather than enhanced increases of calcium sensitivity. We also tested whether MCA rely more on calcium release from intracellular stores to develop …
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Role of mGluR5 and FMRP in mouse primary somatosensory cortex
… with peak expression prior to synaptogenesis at P14. It is expressed postsynaptically at P7 and pre and postsynaptically at P14. FMRP does not regulate cortical arealisation during barrel formation but results in decreased barrel segregation. In the absence of FMRP, biochemical studies show …
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The Mechanism of Tumorigenesis In The Immortalized Human Pancreatic Cell Lines: Cell Culture Models of Human Pancreatic Cancer
… (90%) and Her2 (70%), loss of p16 (95%) and p14 (40%), inactivation p53 (50-75%) and Smad4 (55%). However, the role of these signature gene alterations in PDAC is still not well understood, especially, how these genetic lesions individually or in combination contribute mechanistically to …
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TBX2 IS INVOLVED IN MYOGENESIS AND ITS DEREGULATION PROMOTES TUMORIGENESIS IN RHABDOMYOSARCOMA
… of cell cycle regulators, such as p21 and p14/p19, and the tumor suppressor PTEN in RMS tumor cells. Knock down of TBX2 significantly decreased the proliferation rate of RMS cells. We also found that loss of TBX2 significantly inhibited tumorigenesis of RMS cells by decreasing cell …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and compared their phenotype and function following infection with the Armstrong (acute) or Clone 13 (chronic) strains of LCMV, or MHV68 expressing the LCMV epitope DbGP33-41. By performing k-means …
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Eye-opening and control of visual synapse development in the mouse superior colliculus
… development, before eye-opening in rodents (-P12-P14). The cortical projection is delayed by about eight days, just reaching the sSC around P4, and does not complete its topographic refinement until around the time of eye-opening. These afferents compete for synaptic space during a time when …
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Cambios epigenéticos, génicos y de expresión proteica en el cáncer de laringe. Análisis del segmento cromosómico 9P21
… tres proteínas implicadas en la carcinogénesis: p14, p15 y p16. Objetivos: 1. Analizar el patrón de alteraciones génicas y de metilación en diversos genes supresores de tumores, centrando nuestro estudio en CDKN2A y CDKN2B, localizados en el segmento cromosómico 9p21. 2. Analizar la expresión de …
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Defining the relationship between maternal care behavior and hearing development in Wistar rats
… significant lower ABR thresholds on P14. Statistical analysis on the latencies and amplitudes of ABR waves (waves I-IV) evoked in peripheral and central auditory system showed statistically significant shorter wave I and wave IV latencies in low-LG offspring compared to high-LG …
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Carbachol- and ACPD-Induced Phosphoinositide Responses in the Developing Rat Neocortex
… binding continued to increase. From P5 - P14, PI-linked metabotropic glutamate receptors are most concentrated in layer IV (Blue et al., 1997), whereas only on P6 was there a correspondingly high ACPD-initiated PI response in this layer. Unlike receptors, the PI response was strong in …
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Regulation of mTOR complex 1 in response to growth factors and nutrients
… We also indentified a complex of three proteins (p14, p18 and MP1), that we call the "Ragulator" complex, as Rag GTPase interacting proteins. The Ragulator itself localizes to lysosomes through lipid modifications on p18, and tethers the Rag GTPases on the lysosomal surface. We speculate that …
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The effects of complex I deficiency on neurogenesis and white matter development in a mouse model of Leigh Syndrome (LS)
… showed an early reduction at postnatal day 14 (P14) in NSC and neuroblast populations within the SVZ, with the neurogenic defect progressing at later timepoints to impaired lineage advancement. To resolve cell type–specific effects of CI deficiency, single-cell RNA sequencing (scRNA-seq) was …
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TWEAK/Fn14 Pathway is Activated by Hypoxia and is a Novel Mediator of Retinal Neovascularization
… compared to RA. Hyperoxia treatment (HT), from P14-P17, has been shown to prevent NV in OIR. Interestingly, HT was associated with normalization of both the TWEAK and Fn14 mRNA to RA levels, further supporting the hypotheses that TWEAK/Fn14 is involved in NV and that hypoxia is an inducer of the …
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