Global ETD Search

Structural-based Investigation of FAK and P130Cas in Focal Adhesion

Zhang, Chi2016

… complexes containing more than 100 proteins. p130cas is a Src substrate localized in FAs that functions in integrin signaling to promote cell motility, invasion, proliferation and survival. The Src homology 3 (SH3) domain of p130Cas can directly interact with Focal Adhesion Kinase (FAK), which …

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NUOVI FATTORI PROGNOSTICO-PREDITTIVI NEI TUMORI STROMALI GASTROINTESTINALI (GIST): STUDIO SUL RUOLO DI CAVEOLINA-1 E p130CAS

Cassoni, Paola, Barreca, AntonellaUniversità degli Studi di Torino2018

unito Repository record for NUOVI FATTORI PROGNOSTICO-PREDITTIVI NEI TUMORI STROMALI GASTROINTESTINALI (GIST): STUDIO SUL RUOLO DI CAVEOLINA-1 E p130CAS (opens in a new tab)

Functional Characterization of Protein Tyrosine Phosphatases in Tumorigenesis through Substrate Identification

Zhang, PengCase Western Reserve University School of Graduate Studies2013

… cancer cells. We identified and validated that p130Cas is a direct substrate of PTPN14 and PTPN14 dephosphorylates p130Cas at the tyrosine 128 residue. To dissect the role of pY128 p130Cas in colorectal tumorigenesis, we engineered p130Cas Y128F mutant knock-in colorectal cancer cell lines. The …

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The adaptor protein p130Cas controls pancreatic acinar cell plasticity and cancer initiation through regulation of PI3K-AKT pathway

Martini, Miriam, Costamagna, AndreaUniversità degli Studi di Torino2021

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Molecular Mechanism of Tetraspanin CD9 Mediated Cell Motility

Kotha, Jayaprakash2016

… tyrosine phosphorylation of the adaptor protein p130Cas. However, no significant changes in the CD9 enhanced migration were observed in CHO cells upon down regulation of p130Cas CD9, a member of the tetraspanin superfamily of proteins participates in the regulation of cell adhesive functions such …

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The adaptor proteins p130Cas and p140Cap in the control of cancer cell signaling: studies on pancreatic cancer initiation and cholesterol metabolism of breast cancer cells

Defilippi, Paola, Natalini, DoraUniversità degli Studi di Torino2023

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Identifikation von Signalweginteraktionspartnern des Zelladhäsionsmoleküls Muc18/MCAM/CD146

Konak, EdithLudwig-Maximilians-Universität

… Proteine wurden als das Adapterprotein p130Cas (crk-associated substrate) und sein Ligand p105CasL identifiziert. Eine Muc18-assoziierte Phosphorylierung von fak („focal adhesion kinase“) und fyn (eine Proteintyrosinkinase der src-Familie) wurde nicht beobachtet. P130Cas und p105CasL, …

lmu-germany Repository record for Identifikation von Signalweginteraktionspartnern des Zelladhäsionsmoleküls Muc18/MCAM/CD146 (opens in a new tab)