Global ETD Search
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Showing 1 to 3 of 3 for “"p120RasGAP"”.
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Studies on the Molecular Mechanisms of Tumorigenesis in Neurofibromatosis Type 1
… and Western blot analysis. RASA1 gene encodes p120RasGAP, which is first described as a negative regulator of Ras in 1988. To find out the reason why RASA1 gene was down-regulated in the malignant cells, we had checked methylation status in CpG island on the promotor region of RASA1. But, we …
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Molecular Genetic Analysis of Tumor Cells and Developmenet of RNA Interferance Therpy in Neurofibromatosis Type1(NF1)
… product of the NF1 tumor suppressor gene, and p120RasGAP are GTPase-activating proteins for p21 and negatively regulate output by accelerating GTP hydrolysis on Ras. Neurofibromin and p120RasGAP differ markedly outside of their conserved GAP-related domains (GRDs), and it is therefore unknown …
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Development and Characterization of Novel Ras Inhibitors
… isoforms, we targeted the catalytic domain of p120RasGAP to the plasma membrane with the hypervariable region (HVR) of H-Ras (GAP-CTH) or K-Ras (GAP-CTK) and to the Golgi using the HVR of H-Ras with insertion of a point mutation (GAP-CTH181S). We performed GST-RBD pull-downs on cells expressing …