Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"p115"”.
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Molecular mechanisms of the unconventional secretion of macrophage migration inhibitory factor (MIF)
… with the novel MIF interaction partner p115, a Golgi-associated protein that takes part in the ER/Golgi secretion pathway. By confocal microscopy, I was able to demonstrate that MIF and p115 are associating in the cytoplasm; following activation, macrophages redistribute MIF to the …
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Characterising the factors involved in ER-to-Golgi anterograde trafficking
… This phenotype was also recreated when p115, a GM130 binding partner of unclear function, was knocked down using siRNA. The ER exit site dispersal phenotype was unique to GM130, as the loss of GMAP210 and giantin did not produce a similar effect. Therefore, GM130 possesses a unique role …
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Pharmacological investigations into matrix metalloproteinase-activated anti-tumour prodrugs. In vitro metabolic and pharmacological investigations into a series of colchicine-based peptide prodrugs activated by tumour-expressed matrix metalloproteinases
… ilomastat (metalloproteinase inhibitor) and BML-P115 (matrix metalloproteinase inhibitor). Moreover, members of the MMP family responsible for cleaving the selected prodrugs were identified using recombinant MMP enzymes. Furthermore, a LC/MS-MS method was developed to specifically detect and …
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From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster
… (Leukemia-associated RhoGEF), PDZ-RhoGEF and p115 RhoGEFs. In addition to a catalytic module, DRhoGEF2 encompasses an N-terminal PSD-95/Dlg/ZO-1 (PDZ) domain, a Regulator of G-protein Signaling (RGS) domain and a cysteine-rich diacylglycerol (DAG)-binding domain in the central region. …
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Analysis of protein-protein interactions linked to the formation of a bacterial cytoskeleton in Mycoplasma pneumoniae
… (P90), MPN160, MPN297, MPN392 (PdhB), MPN426 (P115), MPN430 (GAPDH), MPN447 (HMW1), MPN573 (GroEL), MPN665 (EF-Tu). These results confirm the two-hybrid analyses of proteins interacting with HMW2. Eight of them (P1, P90, PdhB, GAPDH, HMW1, GroEL, EF-tu and the gene product of MPN297) were also …
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The Role of Vav-1, Vav-2 and Lsc in NK T cell development and NK cell cytotoxicity
The hematopoietic-specific Rho-family GTP exchange factor (GEF) Vav-1 is a regulator of lymphocyte antigen receptor signaling and mediates normal maturation and activation of B and T cells. Recent findings suggest that Vav-1 also forms part of signaling pathways required for natural and antibody …