Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"p110-alpha"”.
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Mechanistic Investigation of Genotype-Phenotype Correlations in PIK3R1-Related Diseases
The PIK3R1 gene encodes three proteins - p85$\alpha$, p50$\alpha$ and p55$\alpha$ - that are regulatory subunits of Class IA phosphoinositide 3-kinases (PI3Ks). These regulatory subunits heterodimerise with one of three catalytic subunit isoforms, namely p110$\alpha$, p110$\beta$, or p110$\delta$. …
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The Effect of Manipulation of the Phosphoinositide 3-kinase Pathway on Axon Regeneration in vivo
… adopted to conditionally express the hyperactive p110$\alpha$ and p110$\delta$ PI3K isoforms using viral Cre recombination. Both survival and axon regeneration were significantly increased 4 weeks post-ONC injury in young and aged mice. No significant difference between the two isoforms was …
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The effects of maternal diets, varying in fat content, on proximal hepatic and skeletal muscle insulin signalling in neonatal wistar rat offspring
… insulin signalling factors: insulin receptor alpha (IRα), insulin receptor substrate 2 (IRS2) and phosphoinositide 3-kinase-p110 alpha (PI3K-p110α), and to assess the therapeutic potential of Aspalathus linearis extract after high fat programming. Pregnant rats were randomised into groups …
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Cardiac PI3Kα Signaling and K+ Channel Regulation in Cardiac Hypertrophy and Heart Failure
… constitutively active phosphoinositide-3-kinase-p110α: caPI3Kα), were utilized. Electrophysiological experiments revealed that repolarizing K<super>+</super> current amplitudes were increased and K<super>+</super> current densities were normalized in hypertrophied ventricular myocytes from …
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PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
… (PI3K), composed of a p85ƒÑ regulatory and a p110ƒÑ catalytic subunit, participates in multiple cellular processes, including cell growth and survival; however, the role of PI3K in liver regeneration has not been clearly delineated. In these studies, I used the potent PI3K inhibitor, …