Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"p110δ"”.
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Elucidating the molecular mechanisms of p110δ activation in T cell antigen receptor signalling
… of PI3K activity. The class IA catalytic isoform p110δ is known to be the dominant PI3K involved in signal transduction downstream of the TCR. However, the mechanism by which the TCR recruits and activates p110δ remains unresolved. This study has used a combination of proteomic, biochemical and …
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Investigating the isoform-specific role of phosphoinositide 3- kinase p110delta
… subunits of class IA PI3Ks are p110α, p110β and p110δ. PI3Ks are involved in multiple cellular processes, and deregulation of PI3K signalling pathways have been linked to a number of diseases such as cancer, inflammation and immunity and diabetes. Targeting PI3K itself or downstream effectors of …
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The role of BCAP in regulating the TLR signalling pathway
… an extensive interactome, in which PI3K p85α/p110δ and PLCγ2 were associated with the negative regulation of the TLR4 pro-inflammatory response. It is hypothesised that BCAP may facilitate the recruitment and activation of PI3K and PLCγ2 to the TLR signalosome. In this study, a robust protocol …
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Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model
… that CSF-1R signaling, independent of PI3K p110δ signaling, contributes significantly to tumor growth and to tumor-induced osteolysis in this model.