Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"p-proteins"”.
-
Exploring the molecular architecture of proteins: Method developments in structure prediction and design
<p>Proteins are molecular machines of life in the truest sense. Being the expressors of genotype, proteins have been a focus in structural biology. Since the first characterization and structure determination of protein molecule more than half a century ago1, our understanding of protein structure …
-
Coordination Between Autophagy and the Heat Shock Response: Evidence From Exercise in Animals and Humans
<p>Proteins play a critical role in nearly every biological activity. In consequence, organismal health and homeostasis often hinges on the ability of intracellular regulatory systems to sustain the quality and function of these diverse, structurally complex macromolecules. Correct protein function …
-
Investigating protein folding by the de novo design of an α-helix oligomer
<p>Proteins are composed of a unique sequence of amino acids, whose order guides a protein to adopt its particular fold and perform a specific function. It has been shown that a protein's 3-dimensional structure is embedded within its primary sequence. The problem that remains elusive to …
-
Efficient New Computational Protein Design Algorithms, with Applications to Drug Resistance Prediction and HIV Antibody Design
<p>Proteins are essential for myriad biological functions, including DNA replication, molecular transport, catalysis, and antigen recognition. Protein function is determined by three dimensional structure, which is largely determined by amino acid composition. The functional diversity of known …
-
Dissection of phloem transport in cucurbitaceae by metabolomic analysis
… in internal central phloem. 10) Aggregated P-proteins were manually dissected from central phloem and analysed by both SDS-PAGE and mass spectrometry. Partial sequences of peptides were obtained by QTOF de novo sequencing from trypsin digests of three SDS-PAGE bands. None of these partial …
-
Improving Structural Features Prediction in Protein Structure Modeling
<p>Proteins play a vital role in the biological activities of all living species. In nature, a protein folds into a specific and energetically favorable three-dimensional structure which is critical to its biological function. Hence, there has been a great effort by researchers in both …
-
Biochemical Characterization of Two Aminopeptidases Involved in Hemoglobin Catabolism in the Food Vacuole of Plasmodium falciparum
… environment is unique for aminopeptidase P proteins and rare for M1 homologs. Our immunolocalization results have confirmed the dual distribution of these two enzymes in the parasite. Vacuolar targeting was found to be associated with the Plasmodium specific N-terminal extension found in the …
-
Catalase-loaded liposomal magnesium phosphate nanoparticles for intracellular protein delivery
<p>Proteins are large biomolecules that have great therapeutic potential in treating many human diseases. Proteins exert higher specificity and more complicated functions; they are well endured and less inclined to evoke immune responses when compared to small molecule drugs. However, exogenous …
-
Highly Accurate Fragment Library for Protein Fold Recognition
<p>Proteins play a crucial role in living organisms as they perform many vital tasks in every living cell. Knowledge of protein folding has a deep impact on understanding the heterogeneity and molecular functions of proteins. Such information leads to crucial advances in drug design and disease …
-
New Methods to Improve Protein Structure Modeling
<p>Proteins are considered the central compound necessary for life, as they play a crucial role in governing several life processes by performing the most essential biological and chemical functions in every living cell. Understanding protein structures and functions will lead to a significant …
-
Post-Translational Modification of Proteins via Ambient Air Pollutants and Endogenous Reactive Species
<p>Proteins can react with reactive oxygen species (ROS) and reactive nitrogen species (RNS) to form post-translational modifications (PTMs), which can affect protein structure and function. The formation of 3-nitrotyrosine (NTyr) and dityrosine (DiTyr) upon reaction of proteins with ROS/RNS are …
-
Detection of Proteins by Two-Photon Excitation of Native Fluorescence
<p>Proteins are of primary importance to the structure and function of all living cells. Study of proteins relies on the ability to separate a complex mixture so that individual proteins can be more easily processed by other techniques. Since protein samples often exist at low concentration in a …
-
De Novo Protein Structure Modeling from Cryoem Data Through a Dynamic Programming Algorithm in the Secondary Structure Topology Graph
<p>Proteins are the molecules carry out the vital functions and make more than the half of dry weight in every cell. Protein in nature folds into a unique and energetically favorable 3-Dimensional (3-D) structure which is critical and unique to its biological function. In contrast to other methods …
-
Investigation Into Protein Folding and Misfolding
<p>Proteins are the fundamental building blocks of all living organisms. They are critical in the proper function of virtually all cellular processes and without them biological life would be impossible. Since their discovery, understanding the transition of DNA to functional protein has been …
-
Using Protein-Likeness to Validate Conformational Alternatives
<p>Proteins are among the most complex entities known to science. Composed of just 20 fundamental building blocks arranged in simple linear strings, they nonetheless fold into a dizzying array of architectures that carry out the machinations of life at the molecular level.</p><p>Despite this …
-
Building Better Backbones: Visualizations, Analyses, and Tools for Higher Quality Macromolecular Structure Models
… empowering users to improve structures.</p><p>Proteins and nucleic acids are among the most important molecules in biology, mediating the majority of biochemical processes that comprise a living organism. Therefore, these macromolecules are important targets, both for basic research to improve …
-
Synthesis and Characterization of Protein-Polymer Core-Shell Structures
<p>Proteins and bionanoparticles (BNPs) are the key building blocks of all biological matters. The study of their self-assembly behavior with various polymers is of increasing interest for development of functional materials. Compared to inorganic or organic nanoparticles, BNPs are truly …
-
Zusammensetzung eukaryotischer RNase P aus pflanzlichen Zellkernen und Plastiden
… jedoch keinerlei Bindung des RNase P Proteins aus E. coli. Die hohe Spezifität der Antikörper für ein Cyanellen-RNase P-Protein konnte durch Immunopräzipitations-Experimente bestätigt werden. Da im vollständig sequenzierten Cyanellen-Genom keine zu RNaseP-Proteinen homologe Sequenz …
-
A novel in vivo protein refolding technique
<p>Proteins perform their functions in their native folded states and misfolding of proteins may cause severe diseases, including Alzheimer's disease, Parkinson's disease, prion disease and diabetes. Understanding protein folding is important for us to engineer proteins to treat these diseases. For …
-
Natural and Synthetic Ligand-Binding Induce Different Pilin Assemblies in vitro and Control P. aeruginosa Bioactivities in vivo, and Development of Bacterial-Motility Enabled Binding Assays
<p>Proteins found on bacterial cells surfaces are capable of sensing and transducing signals from the environment to elicit a biological response. Fibrous appendages formed by assembly of pilin proteins on P. aeruginosa are surface proteins that are necessary for host colonization, adhesion on …