Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"p-Akt"”.
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Μελέτη του σηματοδοτικού μονοπατιού ILK/p-Akt στο ηπατοκυτταρικό καρκίνωμα του ανθρώπου : συσχέτιση με την έκφραση παραγόντων που εμπλέκονται στην απόπτωση και στον κυτταρικό πολλαπλασιασμό
… Διαπιστώθηκε πως το σηματοδοτικό μονοπάτι ILK/p-Akt διαδραματίζει κομβικό ρόλο τόσο στη βιολογία της κίρρωσης όσο και του ηπατοκυτταρικού καρκίνου και πιθανόν αποτελεί μοριακό σύνδεσμο μεταξύ των δύο καταστάσεων, επιβεβαιώνοντας τη διατυπωμένη θεωρία περί άξονα χρόνιας φλεγμονής-ίνωσης …
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Estudio de la ruta de señalización celular de PI3K-AKT-mTOR en los carcinomas epidermoides nasosinusales
… son tumores de mal pronóstico. La ruta de PI3K/AKT/mTOR es la vía oncogénica mutada más frecuente en carcinomas escamosos de cabeza y cuello (CECC). El papel de la vía PI3K/AKT/mTOR y su implicación clínica y pronóstica en CENS todavía no ha sido investigada. El objetivo de este estudio fue …
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Prenatal Cocaine Exposure and Cardiac Programming
… are not fully understood. Inhibition of PBK/Akt pathway by wortmannin or PKC by chelerjdhrine before ischemia significantly reduced postischemic recovery, and increased infarct size in female but not male hearts. Although the levels of total Akt or PKCs were same between male and female …
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The Role of Trophic Factors and Other Drugs in the Treatment of Huntington's Disease in R6/2 Mouse Model
… and apoptosis pathways of neurons, including Akt kinase and JNK. We hypothesized that the treatment of the R6/2 transgenic mouse model with neurotrophic peptides, Colivelin and analogue dPEG-Colivelin, Sulforaphane, a compound that reduces oxidative stress, and Ceftriaxone, a GLT-1 …
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Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway
… of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, a crucial regulator of cell survival, is associated with poor outcome in neuroblastomas and our lab¡¦s previous work has shown that GRPR regulates the expression of PI3K/Akt pathway components. However, the signaling mechanisms involved …
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Effects of Polyphenols on Vasomodulatory Factors and Associated Cell Signalling
… of improved endothelial function. Specifically, Akt and eNOS phosphorylation, levels of total eNOS protein and cGMP, secretion of ET-1 and levels of nitrate/nitrite in cell culture media were assayed. Alongside these experiments, HUVECs were treated with quercetin, a flavonol found in a number of …
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Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas
… expression. Several components of the Her-2/PI3K/Akt pathway were evaluated for their relevance as potential prognostic markers or indicators for treatment. A secondary objective was to evaluate the CISH technique for its suitability for analysis of Her-2 gene amplification on archived, …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
… decreased the levels of the AR, phosphorylated Akt (p-Akt), and IGF-1R within the prostates of these mice. When 6-week-old, intact, male TRAMP mice were fed an AIN-76A diet containing 1286 ppm of OSU-CG5 for approximately 18 weeks, prostate tumor development was not suppressed or significantly …
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Sphingolipids Modulate the Inflammatory and Functional Response in mdx Mice
… stained with H&E and immunohistochemistry for p-Akt was performed. At age 9 weeks, in vivo ankle flexor torque at stimulation frequencies 50-150 Hz was greater in mdx+S vs. mdx (P=0.0160) and WT (P<0.0001). At 11 wks, only WT+S EDL stress in vitro was greater than all other groups at 50-150 Hz. …
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Effects of essential amino acids supply and body condition prepartum on antioxidant, inflammation and mechanistic target of rapamycin pathways in adipose tissue during the periparturient period
… proteins phosphorylated (p) protein kinase B (p-AKT). A diet×day interaction was observed for mTOR protein abundance due to greater values for RPM cows at 30 d postpartum compared with controls. Additionally, supply of Met resulted in an overall upregulation of protein abundance of glutathione …
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Glycemic control and pancreatic beta cells protective effect of a lanosteryl triterpene from Protorhus longifolia in hyperlipidemic and STZ-induced diabetic rats
… IRS-1Ser307 expression along with increases in p-Akt, p-GSK-3β and GLUT 4 expression were observed in the RA-3 treated group vs untreated diabetic controls. Finally, the molecular basis of RA-3 in hyperlipidemic and STZ-induced type 2 diabetes in animals was studied. Diabetic animals treated with …
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Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer
… was associated with decreases in PMAPK and P-Akt, and G1 cell cycle arrest. Combined treatment with gefitinib and chemotherapy was more effective than either gefitinib or chemotherapy alone. EGFR and P-EGFR expression were examined by immunohistochemistry in 101 breast tumours. Only 6 % were …
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The role of Dietary Interventions in Broiler Intestinal Health and Immunity
… enhanced protein expression levels of p-Akt. MRF-2 and MRF-3 dietary incorporation led to a significant decrease in RIPK3 protein expression levels. Dietary additive inclusion had little effect on serum and tissue lysate expression of inflammatory cytokines. The work in this thesis …
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The effect of RAN inhibition on human colorectal cancer cells (CRC)
… signalling molecules such as p- Erk 1/2 and p- Akt were upregulated after MBZ treatment and exert inhibition on Akt 1/2/3 and VEGFR1/2 mRNA levels. In conclusion; MBZ which is a Ran inhibitor, has significantly reduced proliferation, colony formation, and migration in colorectal cell lines with …
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The Role of K63-Linked Ubiquitination Cycles In Akt Kinase Activation
<p>Akt (also known as protein kinase B) serves a central regulator in PI3K/Akt signaling pathways to regulate numerous physiological functions including cell proliferation, survival and metabolism. Akt activation requires the binding of Akt to phospholipid PIP3 on the plasma membrane and subsequent …
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Role of lncRNA in cancer development and progression
… of PICART1 lowered down the levels of p-AKT (Thr308 & Ser473) and p-GSK3β (Ser9), and accordingly, β-catenin, cyclin D1 and c-Myc expression were decreased, but p21cip1/Waf1 expression was increased. Together these data suggest that PICART1 is a novel p53-inducible tumor suppressor …
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EFFECTS OF REPEATED ARIPIPRAZOLE TREATMENT ON THE cAMP AND AKT PATHWAYS IN THE DORSAL STRIATUM OF PREADOLESCENT AND ADULT RATS
… receptors. PKA subunits and components of the Akt pathway were measured using Western Blots. Results showed that repeated treatment with haloperidol or aripiprazole did not significantly affect D2-like receptor efficacy or potency in young or adult rats. In both age groups, haloperidol …
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Characterization of Metabolic Differences in Benign, Slow Developing and Tumor Initiating Ovarian Cancers
… chemotherapeutic agent sphingosine decreased p-AKT protein levels in the cell, decreased the glycolytic rate and decreased de novo cholesterol synthesis. Cancer stem cells are known to be resistant to chemotherapy treatments and targeting their metabolism may be promising for combinatorial …
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Eph-mediated restriction of cerebrovascular arteriogenesis
… and limits EC growth via suppression of p-Akt in vitro (2) EC-specific EphA4 ablation leads to increased collateral remodeling, enhanced blood flow recovery, tissue protection and improved neurological behavioral outcomes after stroke and (3) Mechanistically, EphA4 limits pial collateral …
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Neuroprotective effects of PACAP, VIP and NAP against hyperglycaemic retinal damage
… retina by activating the anti-apoptotic p-Akt, p-ERK1, p-ERK2, Bcl-2 and decreasing levels of the pro-apoptotic elements, such as cleaved caspase-3. These results raise the opportunity for the use of these peptides as a possible therapeutic or preventive methods in treating diabetes.
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