Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"oxytocin receptor"”.
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Investigation of the oxytocin receptor gene in sheep
The increase in uterine oxytocin receptor (OTR)concentrations over the late luteal phase of the estrous cycle in sheep is thought to play an important role in the regulation of the cycle length by facilitating the effect of oxytocin on uterine prostaglandin release. At the end of pregnancy, a …
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Induction of the oxytocin receptor and its role in luteolysis in sheep
… of progesterone on induction of the uterine oxytocin receptor in the absence and presence of estradiol and to determine whether or not estradiol of ovarian follicular origin is necessary for induction of the oxytocin receptor and the pulsatile secretion of prostaglandin F$\sb{2\alpha}$ …
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NEW PHARMACOLOGICAL TOOLS FOR AUTISM RESEARCH: OXYTOCIN RECEPTOR MUTANT MICE AND ZEBRAFISH AS NEUROBEHAVIOURAL MODELS
… behaviour associated to resistance to change. Oxytocin (OT) is a peptidic hormone best known for its role in lactation and parturition. Recently, it has been also shown by several studies involving different lines of knock-out mice to play an important role in the central nervous system (CNS) …
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Social defeat and oxytocin regulation of social avoidance and stress-related signaling proteins
… that social defeat robustly affects the oxytocin system in brain regions relevant for affiliative behaviors. Specifically, oxytocin receptor binding was progressively reduced in the nucleus accumbens (NAc), basal lateral amygdala (BLA), and anterior cingulate cortex (ACC) of defeated …
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Efforts Toward the Total Synthesis of Asparagamine A
… efforts to complete the total synthesis of the oxytocin receptor antagonist asparagamine A are presented. A novel strategy for accessing the pyrrolizidine carbon skeleton of asparagamine A in enantiospecific fashion from L-glutamic acid has been identified. This approach utilizes an …
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The Mechanisms Underlying Olfactory Vicarious Fear Learning in Rats
… alone was sufficient for vicarious learning. Oxytocin has previously been shown to modulate social behaviour as well as fear behaviour, and the release of oxytocin was shown to reduce freezing behaviour after direct and vicarious fear conditioning. However, injecting an oxytocin receptor …
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Ossitocina nella Sostanza Nera del ratto: azione sull'attività locomotoria e interazione con i neuroni dopaminergici, glutammatergici e GABAergici nigrali
Oxytocin, the neurohypophyseal hormone well-known for its hormonal role in lactation and parturition, also exerts a wide range of effects acting in the Central Nervous System as a neuromodulator or neurotransmitter. An increasing number of experimental studies have suggested that, in rodents, …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… is maintained by increased progesterone receptor (PR) transcriptional activity, while spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and negatively impact PR function. In this study, we uncovered a new regulatory …
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Novel hypothalamic G protein-coupled receptors involved in the control of reproduction
In the hypothalamus, various G-protein coupled receptors (GPCRs) form part of the regulatory pathways of the hypothalamus-pituitary-gonadal (HPG) axis. The master hormone regulator of the HPG axis is the gonadotropin-releasing hormone (GnRH). Defects in GnRH neuron activity are associated with …
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Gene Expression in Endometrial Tissues of Normal Mares and Mares With Delayed Uterine Clearance
… [OS]). The genes assayed in this research were oxytocin receptor, PGF2á receptor and progesterone receptor. The expression of each of these genes was normalized using the expression of two housekeeping genes, beta actin and ribosomal 18S RNA. Quantitative real-time polymerase chain reaction …
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Role of estradiol and progesterone in regulating prostaglandin F(2 alpha) secretion and luteolysis in the ewe
… and progesterone on the secretory pattern of oxytocin and the oxytocin-induced secretion of prostaglandin F$\sb{2\alpha}$ (PGF$\sb{2\alpha}$) during luteolysis in the ewe. For the first two studies, fifty mixed-breed ewes underwent selective irradiation of both ovaries on day 8 of the cycle to …
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The Role of TET Proteins in the Epigenetic Regulation of Neural Gene Expression and Behavior
… differences in the Tet1Δe4 mouse brain. The oxytocin receptor (OXTR), a neural gene implicated in social behaviors, is suggested to be epigenetically regulated by an unknown mechanism. Interestingly, several human studies have found associations between OXTR DNA hypermethylation and a wide …
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Oxytocin and Social Sensitivity: Implications for Vulnerability to Stress and Depressive Symptoms
Oxytocin is a neuropeptide that has been implicated in several prosocial behaviors, such as trust, empathy and social affiliation, and might contribute to mental health disorders marked by social disturbances. Indeed, Chapter 1 indicated that the accumulated evidence points to interactions between …
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Variation in postpartum maternal care programs the development of neuroendocrine and mesolimbic dopamine pathways in female offspring
… high maternal LG also predicts elevated estrogen receptor-alpha (ERalpha) and oxytocin receptor levels in brain regions critical for maternal behavior such as the medial preoptic area of the hypothalamus. The first series of experiments within this thesis demonstrates that these neuroendocrine …
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Modulation of Prefrontal Cortex activity and sociability by local interneurons expressing corticotropi-releasing hormone
… a proposed circuit model for cortical serotonin receptor 3 (5-HT3AR) interneurons enriched with corticotropin-releasing hormone (CRH), generated using these established frameworks. Molecular profiling using Translating Ribosome Affinity Purification (TRAP-seq) predicted an elegant, bimodal …
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Neurotransmitter Modulation of Alcohol-Induced GABAergic Signaling in the Central Amygdala
… limited. Neurotransmitter systems such as oxytocin (OXT), corticotropin-releasing factor (CRF), and serotonin (5-HT) have demonstrated therapeutic potential in reducing alcohol-related behaviors. However, how these neuromodulators alter GABAergic transmission in the CeA and interact with …
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A multipronged approach to understanding how genes contribute to social behavior in threespine stickleback
… – glial fibrillary acidic protein (GFAP), oxytocin receptor (OXTR) and tyrosine hydroxylase (TH) in the brain. To enable direct manipulation of genes for social behavior, we focused on aggression. Male sticklebacks demonstrate stereotypical aggressive behaviors during an easily-induced …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
Cancer is the leading cause of death in companion dogs. The high prevalence and impact on animal welfare, combined with biological and environmental similarities to humans, position canine cancers as valuable models for comparative oncology and translational research. Increasing canine life …