Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"oxyntomodulin"”.
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Aib(2)oxyntomodulin Peptide Molecular Self-Assembly: Smart Nanostructures Toward Long Acting Formulation for Obesity and Diabetes Type 2
… have revealed that dual agonist gut hormone, oxyntomodulin (Oxm), has a promising beneficial role to treat obesity and T2DM through suppressing the food intake, raising the energy expenditure, and increasing insulin secretion to maintain the normal blood glucose level in the body. …
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Self-assembled peptide as a long-acting drug formulation
… worldwide rising prevalence [1]. The gut hormone Oxyntomodulin induces satiety and normalizes hyperglycaemia without risk of hypoglycaemic excursions [2]. However, native incretin hormones are quickly degraded by peptidases and renally excreted, which has so far impaired pharmaceutical …
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Optimising the management of new-onset prediabetes/diabetes after acute pancreatitis
… and metabolic-related characteristics). Results: Oxyntomodulin levels were significantly low in NOPAP. Cholecystokinin was the most prominent factor (R2 = 44%) associated with oxyntomodulin after acute pancreatitis. In the prospective cohort of 152 acute pancreatitis patients, at least one out of …
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Effects of exogenous and endogenous factors on appetite regulation in broiler chicks and Japanese quail
… exogenous factor found within plant cells, and oxyntomodulin (OXM), an endogenous hormone generated in the gastrointestinal tract, on food intake in avian models, as well as elucidate the hypothalamic mechanisms responsible. In broiler chicks (Gallus gallus), FA administered peripherally (IP) …
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Effects of Consuming Beans Before or With a Meal on Satiety and Gastrointestinal Hormones Concentration in Obese Men and Women
… ghrelin, peptide YY, glucagon-like peptide and oxyntomodulin by ELISA. Visual analog scale for feelings of hunger and feelings of fullness were recorded at each blood draw. Dietary recalls were completed using Nutrition Data System for Research (NDS-R). The area under the curve (AUC) was …
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Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin and thus may impact intestinal development and dysfunction, type 2 diabetes, and obesity. Evidence suggests that fibers and short-chain fatty acids (SCFAs), particularly butyrate, are classes of nutrients capable of regulating the …
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Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… glucagon-like peptide 2 (GLP-2), glicentin, and oxyntomodulin and thus may impact intestinal development and dysfunction, type 2 diabetes, and obesity. Evidence suggests that fibers and short-chain fatty acids (SCFAs), particularly butyrate, are classes of nutrients capable of regulating the …
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Extrapancreatic actions of incretin-based therapies on bone in diabetes mellitus
… effects of administration of [D-Ala2 ]GIP�oxyntomodulin on bone health in db/db mice were more prominent as the Oxm analogue did not only improve bone strength at tissue level, but also at whole-bone level. These modifications were independent of metabolic status. Twice-daily Exendin-4 …
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Characterisation and pharmacological regulation of GLP-1-mediated glucose homeostasis
… and its closely-related peptide hormones, namely oxyntomodulin (OXM), glucagon (GCG), glucose-dependent insulinotropic polypeptide (GIP), and its metabolite, GLP-1(9-36)NH2, were examined in recombinant cell lines and rodent clonal α and β cell lines using cAMP functional assaying technique. It …
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The metabolic sequelae of oesophago-gastric resection
Bypass or resection of the stomach and oesophagus, has long been recognised to result in profound changes in the handling of ingested nutrients. This results in significant morbidity after radical surgery for oesophago-gastric cancer, in particular post-prandial hypoglycaemia, altered appetite, …