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Showing 1 to 20 of 21 for “"oxylipins"”.
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Characterizing Oxylipins in Human Milk Extracellular Vesicles
… was used to qualify and quantify the presence of oxylipins. The relative content of oxylipins in human milk EVs were analyzed in relation to the relative content of oxylipins in whole human milk, with values standardized to the total protein content. The research found a higher relative abundance …
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New fatty acids, oxylipins and volatiles in microalgae
… ungesättigten Fettsäuren, insbesondere die Oxylipinsynthese, wurde in zwei Cyanobakterienstämmen in vivo und in vitro untersucht. In Nostoc punctiforme PCC 73102 waren zwei Lipoxygenasen (LOXen) kodiert, in Nostoc sp. PCC7120 (identisch zu SAG 25.82) eine bifunktionelle LOX, wobei der …
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Characterization of Free Oxylipins in Extracellular Vesicles from Bovine Milk
… levels across treatments. Results. Twelve oxylipins were detected in bovine milk and EVs. 9-HODE (!2 =0.92) and 15- HEPE (!2=0.91) were highly correlated between EVs and whole milk. 13-HODE decreased by 69% in HTST (p=0.031) compared to the reference. Levels of 17-HDHA and 17(18)-DiHETE …
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The biogeochemistry of lipid derived infochemical signals in the ocean
The role of oxylipins in ocean biogeochemistry was investigated using microcosm amendment experiments, environmental lipidomics, and culture based studies. Oxylipins are a bioactive class of secondary metabolites produced by diatoms and other eukaryotic phytoplankton. Previous research has focused …
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The biogeochemistry of lipid derived infochemical signals in the ocean
The role of oxylipins in ocean biogeochemistry was investigated using microcosm amendment experiments, environmental lipidomics, and culture based studies. Oxylipins are a bioactive class of secondary metabolites produced by diatoms and other eukaryotic phytoplankton. Previous research has focused …
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LL-37 and citrullinated LL-37: differential modulation of the oxylipin - chemokine axis
… to facilitate and regulate airway inflammation. Oxylipins are bioactive lipids that are key mediators in the process of inflammation. The human host defence peptide LL-37 enhances specific oxylipins such as prostaglandin E2 (PGE2) in fibroblasts and endothelial cells. LL-37 plays a pivotal role …
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Quorum sensing for improved production of industrially useful products from filamentous fungi
… and the oxygenated poly-unsaturated fatty acids, oxylipins, are the major signalling molecules reported in filamentous fungi. This study correlates the cell-densities of filamentous fungi to the regulation of their different physiological responses. Two fungal species have been investigated. The …
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Biologically active molecules from marine microalgae
… compounds belong to a class of compounds called oxylipins, that are oxygenated compounds biosynthesized from fatty acids by oxygenasecatalyzed oxygenation. Marine diatoms are able to produce the major antiproliferative oxylipins by a novel oxygenase-dependent oxidation of C16 fatty acids …
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Diverse functions of the two segmentally duplicated 9-lipoxygenases ZmLOX4 and ZmLOX5 of maize
… of a large number of functionally diverse oxylipins. Although the physiological functions of jasmonate-producing 13-LOXs in dicots have been reported and highlighted in host defenses to pathogens and insects, the functions of 9-LOXs and 9-LOX derived oxylipins remain obscure for both …
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Synthesis and application of tagging agents in mass spectrometry-based targeted metabolomics studies
… sensitive detection and quantification of the oxylipins. These compounds are thought to have biological effects on blood flow. Statistical analysis of the results showed no significant change in the amounts of any of the oxylipins in the study pre and post-exercise.;In Chapter five, a study to …
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Functional Study of Lipoxygenase-mediated Resistance to Fungal Pathogens in Maize for Milk-chain Safety and in Grapevine for Sustainable Viticulture
… of polyunsaturated fatty acids (PUFAs) into oxylipins are reported in plants as a response to fungal pathogens. In this respect, lipoxygenase genes (LOXs) play a crucial role in the peroxidation of polyunsaturated fatty acids (PUFAs) into 9(S)- and 13(S)-hydroperoxides, which are further …
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Lipoxygenase Activity in Diatoms : A New Tool to Study the Antiproliferative Effects of Diatoms on Copepod Reproduction
… in transforming polyunsaturated fatty acids into oxylipins. Lipoxygenase activity was measured by a colorimetric and a polarographic assay, and its relationship to oxylipin production was examined. Lipoxygenase metabolism in diatoms was studied under natural conditions during a bloom at sea, under …
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Targeted and untargeted metabolomic profiling of human serum, urine and brain by liquid chromatography mass spectrometry (LC-MS)
… SDB brains.;Oxidised fatty acids have such as oxylipins and prostaglandins have profound effects on human physiology and are present a low levels in biological fluids. In project 4 a novel tagging method for the analysis of oxidised fatty acids was developed. Fatty acids give a relatively weak …
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Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans
… are unclear. Candida produces immunomodulatory oxylipins that cross-react functionally with host eicosanoids, which are considered to play important role in regulating innate and adaptive immune responses. Our objective was to characterize the role of prostaglandins produced by the host and this …
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The remineralization of marine organic matter by diverse biological and abiotic processes
… than 1,100 unique lipids, oxidized lipids, and oxylipins in data from cultures of the marine diatom Phaeodactylum tricornutum that were subjected to oxidative stress. Finally, I present the results of photooxidation experiments conducted with liposomes — nonliving aggregations of lipids — in …
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The remineralization of marine organic matter by diverse biological and abiotic processes
… than 1,100 unique lipids, oxidized lipids, and oxylipins in data from cultures of the marine diatom Phaeodactylum tricornutum that were subjected to oxidative stress. Finally, I present the results of photooxidation experiments conducted with liposomes - nonliving aggregations of lipids - in …
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Genetic, physiological and ecological diversity of the diatom genus <i>Leptocylindrus</i>
… also categorised based on the diversity in their oxylipins pathways. <i>Leptocylindrus danicus</i> and <i>L. hargravesii</i> shared common lipoxygenase pathways, different from the ones shared by the species <i>L. aporus</i> and <i>L. convexus</i>. <i>Tenuicylindrus belgicus</i> exhibits a pathway …
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Investigation of the roles of a membrane-bound caleosin in higher plants
… acid hydroperoxides. The latter are a class of oxylipins that are seen in fungal infection, and also play a role in various aspects of fungal spore development including sporulation and a role in cuticle synthesis. As such, Clo-3 in Arabidopsis and<br/>possibly similar caleosins in other species …
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Identification of chromosomes in hexaploid bread wheat (Triticum aestivum l.) Associated with natural or safener-induced tolerance to halauxifen-methyl
… which are a class of oxidized lipids (oxylipins) that mediate plant responses to biotic and abiotic stresses. Based on these previous findings, my current hypothesis is that safeners utilize an oxylipin-mediated signaling pathway to induce the expression of genes encoding …
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Multi-omic profiling of NPQ improved nicotiana tabacum lines under uniform light conditions
Non-photochemical quenching (NPQ) is an essential process protecting plants from oxidative damage under high light conditions. During the transition from light to shade, photosynthesis is briefly limited based on the rate of NPQ relaxation. Increasing expression of NPQ mediating proteins (VDE, ZEP, …
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