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Showing 1 to 18 of 18 for “"oxygenases"”.
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Molecular Characterization of Two myo-Inositol Oxygenases in Arabidopsis thaliana
Understanding how plants respond to stress is of importance, considering the increasing need to feed a growing population and supply its energy. Plants have complex systems for detecting, and responding to stresses. One stress-responsive system involves myo-inositol (Ins). Ins is a precursor for …
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Examination of diverse physiological functions of mammalian heme oxygenases by gene targeting
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Oxygen-dependent enzymes involved in phosphonate biosynthesis
… biosynthetic pathways. Non-heme iron-dependent oxygenases are important enzymes in all domains of life that catalyze various chemical reactions involving the functionalization of an un-activated carbon atom. These enzymes are present in many phosphonate biosynthetic pathways. Chapter 2 will …
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The Physical Chemistry Underlying the Assembly and Midpoint Potential Control in a Series of Designed Protein-Maquettes
… reduction (oxidases), carbon-hydroxylation (oxygenases), and superoxide production (NADH oxidase). In natural oxidoreductases, determination of the course and rates of heme-protein association, what barriers are encountered, what affinity is achieved, and what are the oxidation-reduction …
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Investigating the invasive and cytoprotective properties of the heme binding protein HRG-1 in cancer cells
… we found that HRG-1 interacts with the heme oxygenases that are necessary for heme catabolism. HRG-1 is also required for trafficking of both heme-bound and nonheme-bound receptors and suppression of HRG-1 results in perturbed receptor trafficking to the lysosome. Suppression of HRG-1 in HeLa …
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Mechanisms of ion channel activation in primary cultured and clonal cell lines
… at depolarised potentials. Inhibitors of cyclo-oxygenases, lipoxygenases and cytochrome P-4S0 were ineffectual against arachidonic acid's effects sugtgesting that arachidonic acid may elicit it's effects directly. Measurements of cell volume under hypotonic conditions showed that ROS 17/2,8 …
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Mono-Oxygenase Activity and Nutritional Ecology of Larvae of the Gypsy Moth, Lymantria Dispar
… that older instar larvae have inducible mono-oxygenases (MFOs) that can detoxify pine terpenoids. To test this hypothesis, NADPH oxidase and O-demethylase specific activities were determined using midgut microsomes from gypsy moth and other polyphagous, lepidopterous larvae fed foliage or …
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Gas migration inside proteins: Mechanism, characterization, and applications
… for many classes of proteins such as globins, oxygenases, and oxidases, which store oxygen gas or use it for enzymatic purposes. One reason why this process has not received prominent attention in recent years was because of difficulties in identifying the pathways taken by oxygen or other …
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Heme Oxygenase-2 as a novel target to treat inflammation and chronic neuropathic pain associated with corneal injury and surgery
… response. Among these mechanisms, the heme oxygenases systems seem to play a major role. In the recent years the heme oxygenase system (HO-1 and HO-2) has emerged as a fundamental endogenous cytoprotective and anti-inflammatory system in many tissues. It is readily upregulated in response to …
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CT610: A Mn-Dependent Self-Sacrificing Oxygenase in p-Aminobenzoate Biosynthesis in Chlamydia trachomatis
… low sequence similarity to non-heme diiron oxygenases and the previously solved crystal structure revealed a diiron active site. Taken together, CT610 is proposed to be a novel self-sacrificing enzyme that uses one of its active site tyrosine residues as a precursor to pABA in a reaction …
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I. Biomimetic oxidations using non-heme iron catalysis. II. Palladium- and hypervalent iodine-catalyzed tandem wacker-dehydrogenation of terminal olefins
… bark. This result suggested that non-heme iron oxygenases were responsible for metabolizing cafestol to tricalysiolide B within tricalysia dubia, and demonstrated how non-heme iron catalysis can be used to rapidly test biosynthetic proposals. II. PALLADIUM AND HYPERVALENT IODINE-CATALYZED TANDEM …
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Biochemical Characterization of Self-Sacrificing P-Aminobenzoate Synthases from Chlamydia Trachomatis and Nitrosomonas Europaea
… showed an architecture similar to know diiron oxygenases. However, we provide evidence of a moonlighting function in pABA synthesis. Isotopic labeling experiments to understand what substrate might be used by CADD found that isotopically labeled tyrosine was incorporated into the final pABA …
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Development of oxygenase biocatalysts for the production of synthetically useful cis-diol compounds
… regio- and stereo-selective Rieske non-heme iron oxygenases, such as toluene dioxygenase (TDO), are versatile synthons for chiral, asymmetric synthesis. The cis-dihydroxylation of ortho- and meta-substituted phenols by TDO produce cyclohexenone cis-diols. The keto group of cyclohexenone cis¬-diol …
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A Radical Approach to Syntheses and Mechanisms
… in the oxidation of tertiary amines by monoamine oxygenases and the cytochrome P450 family of enzymes. Radical cations are believed to undergo deprotonation as a key step in catalysis. KIE studies performed by previous researchers indicate N,N-dimethylaniline radical cations deprotonate in the …
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Molecular analysis of the responses of Caenorhabditis elegans (Bristol N2), Panagrolaimus rigidus (AF36) and Panagrolaimus sp. (PS 1579) (Nematoda) to water stress
… of a large number of genes encoding mono-oxygenases, which may suggest onset of oxidation stress during desiccation of C. elegans. The late response was characterized by the appearance of transcripts encoding proteins of the immune system, heat shock proteins (protein denaturation), and …
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Exploring the impact of hydrogen peroxide delivery methods on PaDa-I enzyme deactivation during styrene biotransformation within tandem catalysis framework
… as active in these transformations including oxygenases, oxidases, hydroxylases, peroxidases and peroxygenases. One of the most promising classes of enzymes are unspecific peroxygenases (UPOs). These enzymes are able to use hydrogen peroxide (H2O2) as the oxidant and electron donor without the …
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Xenobiotic monooxygenase activity and the response to inducers of cytochrome P-450 during embryonic and larval development in fish
Data demonstrating the presence and inducibility of the xenobiotic monooxygenase system in fish embryos and larvae are described. The ontogeny of benzo(a)pyrene monooxygenase (BPM) activity, and NADPH- and NADH-cytochrome c reductase activities, were followed in microsomes prepared from whole …
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A Radical Approach to Photochemical Transformations Using Earth-Abundant Metals
… P450 enzyme and non-heme iron-dependent oxygenases, we developed RLT catalysis to incorporate diverse functionalities to minimally functionalized alkenes. This efficient ligand transfer process outcompetes unproductive ATRA, indicating a powerful reaction manifold for functionalizing …