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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 124 for “"oxygenase"”.
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Towards biosensor-assisted directed evolution of myo-inositol oxygenase
… work was the directed evolution of myo-inositol oxygenase (MIOX), the enzyme that catalyzed the penultimate, rate-limiting step in the metabolic production of glucarate from glucose in E. coli. Here, we develop a biosensor that recognizes glucuronate, the direct product of MIOX, and optimize our …
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Induction of Heme Oxygenase By a Carbon Monoxide-Releasing Molecule
We have recently demonstrated that heme oxygenase is expressed in both healing wounds and in pressure ulcers. Heme oxygenase has been shown to have important cytoprotective functions in myocardial ischemia-reperfusion injury and organ allograft survival. The cytoprotective effects of heme oxygenase …
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Studies on the Mechanism of Protocatechuic Acid 4: 5 Oxygenase
Made available in DSpace on 2014-12-10T23:24:29Z (GMT). No. of bitstreams: 1 7317490.pdf: 2179459 bytes, checksum: 198b6e1080790a37ea7e21670b01b91a (MD5) Previous issue date: 1972
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Components and Properties of the Ketolactonase I Enzymatic Oxygenase System
Made available in DSpace on 2014-12-09T17:36:28Z (GMT). No. of bitstreams: 1 7001021.pdf: 2938748 bytes, checksum: 94a457888caafb6afcb19e7d5d3b1afa (MD5) Previous issue date: 1969
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Toward Engineering Oxygenase Activity into the Electron Transfer Protein Azurin
… of this work is successful engineering of monooxygenase function into model proteinic scaffolds. We seek to model within a prototype scaffold the function of the PHM (peptidylyglycine--hydroxylating monooxygenase) and DβM (dopamine -monooxygenase) family of enzymes, which are capable of …
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Role of the Haem Oxygenase Pathway in Protection against Vascular Dysfunction
… One such mechanism is the induction of the haem oxygenase (HO) pathway. Haem oxygenase is the mammalian enzyme which degrades haem to the antioxidant biliverdin and carbon monoxide (CO) releasing ferric (Fe3+) iron. Biliverdin is rapidly converted to another potent antioxidant, bilirubin, by the …
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Variation in the Substrate Specificity of Ribulose-1,5-Bisphosphate Carboxylase/oxygenase
… of ribulose-1,5-bisphosphate (RuBP) carboxylase/oxygenase were investigated in order to identify conditions which alter the carboxylation and oxygenation functions differentially. Primary emphasis was on the CO(,2)/O(,2) specificity factor (SF = V(,c)K(,o)/V(,o)K(,c)) which was determined by …
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Development of oxygenase biocatalysts for the production of synthetically useful cis-diol compounds
… regio- and stereo-selective Rieske non-heme iron oxygenases, such as toluene dioxygenase (TDO), are versatile synthons for chiral, asymmetric synthesis. The cis-dihydroxylation of ortho- and meta-substituted phenols by TDO produce cyclohexenone cis-diols. The keto group of cyclohexenone cis¬-diol …
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Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
In the past few years, heme oxygenase (HO) has been regarded as a potential pharmacological target, especially the inducible isoform, heme oxygenase-1 (HO-1). HO catalyzes the rate-limiting step of endogenous heme degradation, releasing carbon monoxide (CO), free iron (Fe2+), and biliverdin (BV), …
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Upregulation of heme oxygenase-1 and activation of Nrf2 by the phytochemicals in protandim
… including the endogenous antioxidant heme oxygenase-1 (HO-1), with activation of nuclear factor E2 p45-related factor 2 (Nrf2), and protection from oxidative stress induced apoptosis. In cultured cardiomyocytes, treatment with Protandim was associated with activation of Nrf2 and a …
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Mono-Oxygenase Activity and Nutritional Ecology of Larvae of the Gypsy Moth, Lymantria Dispar
… that older instar larvae have inducible mono-oxygenases (MFOs) that can detoxify pine terpenoids. To test this hypothesis, NADPH oxidase and O-demethylase specific activities were determined using midgut microsomes from gypsy moth and other polyphagous, lepidopterous larvae fed foliage or …
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CT610: A Mn-Dependent Self-Sacrificing Oxygenase in p-Aminobenzoate Biosynthesis in Chlamydia trachomatis
… low sequence similarity to non-heme diiron oxygenases and the previously solved crystal structure revealed a diiron active site. Taken together, CT610 is proposed to be a novel self-sacrificing enzyme that uses one of its active site tyrosine residues as a precursor to pABA in a reaction …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… and reduced protein expression of brain heme oxygenase-1 (HO-1), a highly inducible detoxifying enzyme with antioxidant and anti-inflammatory functions. We further demonstrated that HIV infection of macrophages reduces HO-1 RNA and protein and that this HO-1 loss is associated with neurotoxic …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… chronic inflammation, and oxidative stress. Heme oxygenase-1 (HO-1) is a highly inducible, detoxifying enzyme critical for limiting oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) and other tissues. Our analysis of HO-1 expression in the brain prefrontal …
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Isolation, characterization and expression ofcDNA and genomic sequences encoding ribulosebisphosphate carboxylase/oxygenase activase from barley
Ribulosebisphosphate carboxylase/oxygenase (EC 4.1.1.39, rubisco) catalyzes either the carboxylation or oxygenation of ribulose-1,5-bisphosphate (RuBP) to initiate either the Calvin cycle or the photorespiratory pathway. Rubisco needs to be activated in order to catalyze these reactions. Rubisco …
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Discovery and characterization of a set of peptide-modifying heme oxygenase-like domain-containing oxidases
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Structure and expression of Spinacea oleracea L. and Arabidopsis thaliana complementary-DNAs encoding ribulosebisphosphate carboxylase/oxygenase activase
Rubisco activase proteins consist of two immunologically related polypeptides in the range of 40- to 47-kDa in most plant species examined. Rubisco activase precursor polypeptides are synthesized on cytoplasmic ribosomes and post-translationally imported into the chloroplast with cleavage of a …
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"The Regulation of Pheophorbide a Oxygenase (Pao) in the ""Green Seed"" Problem in Canola and During Leaf Senescence"
… conditions have been identified. Pheophorbide a oxygenase (PaO) is considered to be a key enzyme in regulating chlorophyll degradation. Pheophorbide a, the substrate of PaO, and other chlorophyll catabolites from canola seeds accumulated after exposure to freezing conditions. Freezing was found …
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