Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"oxygen-glucose deprivation"”.
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Neuroprotective Effects of Propofol and Ketamine(alone or combined) Against Oxygen-Glucose Deprivation-Reperfusion Injury
"허혈-재관류 뇌손상에 대한 Propofol, Ketamine 단독 혹은 혼합 투여의 효과 연구 목적 : Propofol 과 ketamine 은 뇌보호 작용이 있는 것으로 알려져 있으나, 이들 두 약제를 동시에 사용하는 것이 뇌보호 작용에 어떤 효과가 있는지에 대하여는 잘 알려져 있지 않다. 본 실험연구는 propofol 과 ketamine 을 같이 사용하는 것이 허혈-재관류로 인한 뇌손상으로 부터 뇌세포를 보호하는데 부가적인 효과가 있는지 알아보기 위하여 시행하였다. 연구 방법 : 13일째 혼합 배양된 세포를 무산소, 무포도당 …
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The Influence of Propofol Administration Time on Oxygen Glucose Deprivation-Reperfusion Injury in Rat mixed Cortical Cultures Focused on N-Methyl-D-Aspartate (NMDA) Receptor
… cultures were exposed to a 5 min combined oxygen glucose deprivation(OGD, in vitro ischemia model), followed by 2 hr reoxygenation(reperfusion). Propofol (1, 10 25, 50, 100 μM) were treated from 1 hr prior to the OGD injury (pre-treatment)or from the initiation of the OGD …
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Excitotoxicity, oxidative stress and neuroprotection in cerebellar granule neurones
… N-methyl-D-aspartate, 3-nitropropionic acid and oxygen-glucose deprivation. Additionally, extensive study was carried out of the actions of increased glucose concentration and a range of metabolites of the essential amino acid tryptophan. It was demonstrated that several tryptophan metabolites …
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The growth-arrest-specific protein gas7 potentiates neuronal differentiation
… did not protect against toxicity triggered by oxygen-glucose deprivation, the calcium ionophore A23187 or sodium nitroprusside. The ability of gas7 to potentiate neuritogenesis and neuronal differentiation makes it a potential therapeutic target to promote re-establishment of neuronal …
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Astrocytes down-regulate microglial inflammatory responses
… activation. Astrocytes were treated with oxygen-glucose deprivation (OGD) or hydrogen peroxide (H₂O₂, 0.01-1 mM), and culture conditioned media (OGDACM or H₂O₂-ACM) were collected. Both OGD-ACM and H₂O₂-ACM collected within 3 h after the treatment strongly reduced iNOS, COX-2, TNF-alpha, …
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Role of Cofilin, an Actin Cytoskeletal Protein, in Ischemic Conditions: Potential Therapeutic Target for Ischemic Stroke
… ischemic models such as oxidative stress, oxygen glucose deprivation (OGD) in vitro and permanent middle cerebral artery occlusion (pMCAO) in vivo were used. The expression profile studies by immunoblotting and fluorescence methods displayed decrease in phosphocofilin (inactive form of …
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Human neural stem cells over-expressing Akt1 provide cytoprotection and functional recovery in mouse stroke model
… proliferation, growth, survival, apoptosis and glucose metabolism. A previous study has shown that transplanted human neural stem cells (hNSCs) selectively migrate to the brain and induce behavioral recovery in mouse intracerebral hemorrhage (ICH) stroke model. However, many of the grafted hNSCs …
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Testing the Gliocentric Hypothesis of Brain Pathology
… oligodendrocytes. Ischaemia was modelled using oxygen glucose deprivation (OGD). It was determined that astrocytes display regional differences in sensitivity to ischaemic insult. The most sensitive region was the dentate gyrus (DG), and corpus callosum (CC) was the least sensitive. Mature …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… RHSC treated with 5mM LCAR for 2 hours prior to oxygen glucose deprivation (OGD). Under the same conditions we observed an LCAR induced decrease in both necrosis and mitochondrially-mediated apoptosis. To elucidate the mechanism for these data we studied the effect of LCAR on reactive oxygen …
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The role of L-carnitine in preventing mitochondrial dysfunction after neonatal hypoxia-ischemia
… RHSC treated with 5mM LCAR for 2 hours prior to oxygen glucose deprivation (OGD). Under the same conditions we observed an LCAR induced decrease in both necrosis and mitochondrially-mediated apoptosis. To elucidate the mechanism for these data we studied the effect of LCAR on reactive oxygen …
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Ionic dysregulation in white matter damage
… of glutamate receptor activity. Using the oxygen glucose deprivation model of ischaemia, in the mouse brain slice, it was found that ischaemia-induced potassium release is greater in cortical grey than in corpus callosum white matter. This distinction is dependent on release of vesicular …
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TREM-2 Expression and Regulation in Inflammation and Ischaemia
… the mechanisms of TREM-2 regulation in stroke. Oxygen glucose deprivation (OGD) had no direct effect on TREM-2 in N9 microglial cells. However, co-culture with healthy neurons reduced microglial TREM-2 expression, which was abolished in co-culture with OGD neurons, suggesting that in the healthy …
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Development of Techniques for Analysis of the Human Retinal Ganglion Cell Transcriptome: Application to the Role of Calcium in RGC Death in Glaucoma
… was investigated using a simulated ischemia (oxygen glucose deprivation, OGD) model in human organotypic retinal cultures (HORCs). Cell survival was measured by LDH, and RGC loss by immunohistochemistry and QRT-PCR. Western blot assessed proteases. Results: The sectioning technique developed …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… and Nec-1 exerted synergistic neuroprotection on oxygen-glucose deprivation-induced cell death and cerebral ischemia/reperfusion injury. This study provided a new therapeutic strategy for the treatment of stroke by the combination of anti-apoptosis and anti-necroptosis therapy.</p>
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… from the increased generation of reactive oxygen and nitrogen species and/or a decrease in the ability of the cell to scavenge and detoxify the reactive intermediates. Strong evidence supports the notion that oxidative stress serves as an important mediator in leading to alterations in …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… from the increased generation of reactive oxygen and nitrogen species and/or a decrease in the ability of the cell to scavenge and detoxify the reactive intermediates. Strong evidence supports the notion that oxidative stress serves as an important mediator in leading to alterations in …
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The Role of Extracellular Matrix and Matrix-Degrading Proteases in Neonatal Hypoxic-Ischemic Injury
… could neuroprotect in an ex vivo model of oxygen glucose deprivation (OGD) that lacks peripheral immune cell involvement, thus providing insight into the relative contributions of resident microglia and gelatinase activity to the inflammatory sequelae. Results showed that both compounds …
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Pathological mechanisms of the ischemic white matter injury in animal model of lacunar infarction
… from TLR2 deficient mice were more vulnerable to oxygen-glucose deprivation (OGD) than WT OLs. Applying TLR2 agonists after OGD substantially rescued WT OL death with augmentation of ERK1/2 phosphorylation. Treatment with TLR2 agonists also reduced the extent of ET-1 induced ischemic demyelination …
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Bax-Inhibitor-1-vermittelte Neuroprotektion
BI-1 (Bax-Inhibitor-1) konnte in Hefen, Pflanzen und verschiedenen Säugetierzellen vorwiegend als anti-apoptotisches Protein charakterisiert werden.Um die Funktion von BI-1 in Neuronen zu untersuchen, wurde sowohl HA- als auch GFP-getaggtes BI-1 transient und stabil in CSM14.1- (nigro-striatale …