Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"oxygen deprivation"”.
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Effects of Oxygen Deprivation on Pilot Performance and Cognitive Processing Skills: A Pilot Study
… 14,000 ft. are required to use supplemental oxygen. The purpose of this study was to examine how oxygen deprivation below 14,000 ft. affects pilot performance using the Frasca Mentor Advanced Aviation Training Device (AATD), and cognitive processing skills using the Automated …
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Molecular characterization and promoter analysis of the maize cytosolic glyceraldehyde 3-phosphate dehydrogenase gene family
The response of maize (Zea mays L.) roots to oxygen deprivation involves an altered gene expression and protein synthesis. Maize cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been identified as one of the anaerobic polypeptides and mRNAs corresponding to a member of the gpc …
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Functional analysis of the sucrose synthase gene family in Arabidopsis thaliana
… various abiotic stresses. It has been shown that oxygen deprivation up regulates Sus1 and Sus4 and increases total Susy activity. However, the analysis of the plants with reduced expression of both Sus1 and Sus4 revealed no obvious effects on plant performance under oxygen deprivation. Low …
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Implementation of an AI-assisted sonification algorithm on an edge device
Oxygen deprivation at birth leads to brain injury, which can have serious consequences. It is the dominant cause of seizures. Quickly and accurately detecting seizures is a challenging problem for neonates. A severe shortage of medical professionals with the necessary expertise for …
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Design for the most vulnerable: Preventing sudden infant death
… increasing their chances of survival during oxygen deprivation. The crib offers a safer sleeping environment than co-sleeping, as the weight of a parent or the soft material of a pillow can easily suffocate an infant. This thesis discusses and illustrates the design process for a crib that …
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The multifactorial nature of hypoxia-induced drug resistance in cancer: involvement of hypoxia-inducible factor 1
… in the understanding of the cellular response to oxygen deprivation, however the hypoxia-induced mechanisms that contribute to the chemoresistance phenotype are still not well understood. Recent studies have identified hypoxia-inducible factor 1 (HIF-1), a master transcriptional regulator of …
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Identification, mechanisms and treatment of perinatal brain injury
… the cerebral mitochondrial response to in-utero oxygen deprivation is unclear. Compared with preterm fetal sheep, I demonstrated that near-term fetal sheep initially showed a more rapid increase of oxidised cytochrome oxidase during UCO followed by delayed loss, suggesting loss of mitochondrial …
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Ex vivo perfusion optimization of donor liver grafts for transplantation and cell isolation
… low as possible without causing hypoperfusion or oxygen deprivation. Morphologically and functionally, perfusion-isolated hepatocytes generally performed comparably or better than fresh hepatocytes in cell suspension and plate culture. Cumulatively, these findings strongly support the ubiquitous …
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Measurement of the effectiveness of enhanced external counterpulsation on heart rate variability for patients with myocardial ischemia
… Myocardial ischemia is a condition in which oxygen deprivation to the heart muscle is accompanied by inadequate removal of metabolites because of reduced blood flow or perfusion. The study was conducted on three subject groups - 7 patients, 5 controls and 3 normals. Normals had no history of …
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Oxygen and Glucose Deprivation on Human Müller Cells (MIO-M1) and Human Organotypic Retinal Cultures (HORCs) in Relation to Glaucoma
… effect of glaucoma-related insults, specifically oxygen and/or glucose deprivation (OGD) on the survival and genes expression of human Müller cells (MIO-M1), and retinal ganglion cells (RGCs) using the human organotypic retinal culture (HORC) model. Methods: MIO-M1 cells and HORCs were exposed to …
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Regulation of Progression through Unperturbed Mitosis and in the Presence of Environmental Stress
… regulation has been largely neglected. However, oxygen deprivation leads to a rapid and reversible mitotic arrest. Here, anoxia is shown to have rapid effects on spindle and kinetochore function which are proposed to cause the observed efficient activation of the mitotic spindle checkpoint. …
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Inhibitors of tubulin, nitric oxide synthase, and HIF-1 alpha; synthesis, biological, and biochemical evaluation.
… tumor vasculature, the tumor can be destroyed by oxygen deprivation and starvation. The combretastatin (CA) family of small molecules has shown great effectiveness as vascular disrupting agents (VDAs). Structure activity relationship (SAR) studies were continued for the combretastatin family by …
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Classification of Foetal Distress and Hypoxia Using Machine Learning
Foetal distress and hypoxia (oxygen deprivation) is considered a serious condition and one of the main factors for caesarean section in the obstetrics and gynaecology department. It is considered to be the third most common cause of death in new-born babies. Foetal distress occurs in about 1 in 20 …
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Rational enzyme-directed prodrug development : exploiting tumour hypoxia to target the bioactivation of cytotoxic prodrugs
… differences is the presence of areas of low oxygen tension (hypoxia) arising through both diffusion and perfusion-limited oxygen availability. Hypoxia is an important cause of radioresistance and is a independent prognostic indicator for local recurrence, metastatic spread and overall …
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The role of hypoxia in T cell function and immunotherapy
Oxygen deprivation (hypoxia) is an important immunosuppressive mechanism in cancer. The lack of proper blood supply and a high local metabolic demand depletes immune cells of key metabolites including oxygen. Tumour hypoxia is particularly hostile to antitumour cytotoxic CD8+ T cell function by …
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Modeling and estimation for non-invasive monitoring of intracranial pressure and cerebrovascular autoregulation
Brain tissue is highly vulnerable to unbalanced oxygen demand and supply. A few seconds of oxygen deficit may trigger neurological symptoms, and sustained oxygen deprivation over a few minutes may result in severe and often irreversible brain damage. The rapid dynamics coupled with the potential …
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Lipid Biomarkers for Marine Fungi
… microbes can be subjected to nutrient and oxygen deprivation over short timescales. In Chapter 4, we explored the impact of starvation on intact polar lipids and fatty acids in the marine yeast Aureobasidium pullulans, a saprotroph found throughout the global oceans. The results indicated …
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Ubiquitous and Wearable Computing Solutions for Enhancing Motor Rehabilitation of the Upper Extremity Post-Stroke
… stroke, its location in the brain, the extent of oxygen deprivation and the criticality of the neural systems affected. While stroke is a non-cumulative disease, it is nevertheless a deadly pervasive disease and one of the leading causes of death and disability worldwide. Those fortunate enough to …
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The role of NAD+ compartmentation and dynamics in Arabidopsis thaliana
… electron transport chain (mETC) inhibitors and oxygen deprivation treatment did not show significant differences in cytosolic NADH/NAD+ content in ndt1 mutants compared to wild-type. The results provide evidence of disruption of NAD+ balance among organelles in ndt1 mutants and show the power of …