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Showing 1 to 16 of 16 for “"oxygen affinity"”.
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Ligand Diffusion Pathways and Mechanisms for Regulating Oxygen Affinity in Two Model Invertebrate Globins: The E7 Gate and Apolar Tunnel
… ScHbI is completely converted to the R- or high affinity quaternary state by the F97Y mutation or when the dimer interface is completely disrupted by the K30D mutation. In contrast, E7 mutations have little affect on the rates of ligand entry and escape in CerHb. Instead, ligands diffuse through …
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Biophysical Studies Aimed at Potential Therapies of Hemoglobin Associated Diseases
… in the red blood cell (RBC), carries gases like oxygen and carbon dioxide throughout the body. However, various conditions, both genetic and environmental, can impede its ability to perform this (and other) necessary functions. We studied some of the most imperative properties of Hb and the RBC …
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Structural and Functional Characterization of Cyanoglobin: A Peripheral Membrane Hemoglobin in Nostoc commune UTEX 584 (Cyanobacteria)
… coli previously. Cyanoglobin possesses a high oxygen affinity. The study presented here investigated the functional role of cyanoglobin, and encompassed the determination of the kinetic basis for the high oxygen affinity of cyanoglobin through kinetic studies utilizing stopped-flow …
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SYNTHESIS, TESTING AND CRYSTALLOGRAPHIC STUDIES OF ALLOSTERIC MODIFIERS OF HEMOGLOBIN
… (Hb) is to bind, transport and deliver oxygen to tissues; made efficient by endogenous effectors, such as protons and 2,3-diphosphoglycerate. Synthetic allosteric effectors of Hb (AEHs) are also known to modulate Hb oxygen affinity, showing potential for the treatment of sickle cell …
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Electrodeposition of Copper on Ruthenium Oxides and Bimetallic Corrosion of Copper/Ruthenium in Polyphenolic Antioxidants
… diffusion barrier/liner material, has higher oxygen affinity to form different oxides. Three different oxides (the native oxide, reversible oxide, and irreversible oxide) were studied. Native oxide can be formed on exposing Ru in atmosphere. The reversible and irreversible oxides can be formed …
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OXIDATION AND REDUCTION SYNTHESIS OF SURFACE ENHANCED TITANIUM-BASED ELECTRODES FOR ELECTROLYTIC CAPACITORS
… can be made. Alkali earth metals with high oxygen affinity were selected to reduce titanium dioxide. The experiments reveal that mostly alkali–earth-metal-titanates were formed during the reduction process. Full reduction to metallic porous titanium is achieved only with calcium as a …
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Response rainbow trout (Salmon gairdneri) blood gas transport system to temperature, oxygen availability and photoperiod
… environmental fa ctors; temperature (5°, 20°C), oxygen availability «35%, >70% saturation) and photoperiod (16L:8D, 8L:16D) and evaluated by 3-factor analysis of variance. Hemog l obin and hematocrit , indicators of oxygenc arrying capacity increased significantly at the higher temperature, …
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An Exploration of the Effect of Temperature on Different Alloys in a Supercritical Carbon Dioxide Environment
… and chromium. Additionally, nickel has a lower oxygen affinity than iron and therefore the migration of cations into the scale is lower.
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Caratterizzazione strutturale e funzionale dei sistemi emoglobinici di due specie di pesci (Mugil cephalus e Ophisurus serpens) e di due varianti emoglobiniche umane (HbRoma e HbF-SS-Monserrato)
… protein that in vertebrates binds reversibly the oxygen and transport it to the tissue through the circulatory sistem. The aim of this study is to contribute to the knowledge of structural-functional relationship of the hemoglobin molecule through structural and funcional characterisation of human …
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The Structure and Activity of Admetal-Modified Single Crystal Platinum and Gold Electrodes
… These differences are related to the greater oxygen-affinity of Ru under these conditions. Osmium deposition proceeds at a faster rate than ruthenium on both Pt(111) and Au(111) surfaces. The Au(111) surface exhibits preferential deposition of Ru or Os islands near steps in contrast to …
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Ionic regulation in goldfish, Carassius auratus, acclimated to constant and diurnally-cycling temperature conditions
… in terms of their effects on hemoglobin-oxygen affinity while plasma and muscle observations were considered from the standpoint of overall water-electrolyte balance. In general, cycled fish appeared to be capable of stabilizing overall body fluid composition, while simultaneously …
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Novel approach towards pathogenesis and treatment of sickle cell disease
… of Hb, contribute to the production of reactive oxygen species (ROS) in SCD patients. In this work, oxidants showed direct and indirect effects on the main cation permeability pathways involved in dehydration of HbS/S RBCs – Psickle, the Gardos channel and the KCl cotransporter (KCC) - and thus …
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Uptake and Metabolism of 5’-Amp In The Erythrocyte Play Key Roles In The 5’-Amp Induced Model of Deep Hypometabolism
… (0.5 mg/gw) enter a Phase I response in which oxygen consumption (VO<sub>2</sub>) drops rapidly to 1/3<sup>rd</sup> of euthermic levels. The Phase I response appears independent of body temperature (T<sub>b</sub>). This is followed by gradual body temperature decline that correlates with …
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Thermodynamic Investigations of Metalloproteins: Metal as Probe and Protein as Probe
… of some fish exhibit significantly lowered oxygen affinity at low pH, allowing for proton-mediated release of O<sub>2</sub>. This phenomenon, known as the Root Effect, serves as a proton-driven pump delivering O<sub>2</sub> to the swim bladders and eyes of the fish. The clam, ,<italic>L. …
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Auxiliary proton-influenced metal-mediated reactions: dioxygen activation, anion coordination, and catalysis
… of intramolecular hydrogen-bonding on the oxygen affinity of CuN3+ derivatives, where N3 = tris(2-picolin-6-yl)methane (tripic) and analogues are presented in Chapter 2. The key synthetic methodology relies on Pd-catalyzed coupling reactions of lithiated 6-methyl-2-pyridone with …
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ΤΟ ΕΠΙΠΕΔΟ ΤΟΥ 2,3-ΔΙΦΩΣΦΟΡΟΓΛΥΚΕΡΙΝΙΚΟΥ ΟΞΕΩΣ ΤΩΝ ΕΡΥΘΡΩΝ ΑΙΜΟΣΦΑΙΡΙΩΝ ΣΤΗΝ ΔΡΕΠΑΝΟΚΥΤΤΑΡΙΚΗ ΝΟΣΟ
… BY A DIMINISHED SATURATION OF HEMOGLUBIN WITH OXYGEN IN THE ARTERIAL BLOOD.