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Showing 1 to 20 of 140 for “"oxidoreductase"”.
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Structures of oxalate oxidoreductase : C₂ activation by a microbial TPP-dependent ferredoxin oxidoreductase
… discovered. M thermoacetica employs an oxalate oxidoreductase (OOR) to oxidize oxalate to two molecules of C0 2, generating two low-potential electrons. OOR uses a thiamine pyrophosphate (TPP) cofactor to cleave the C-C bond, and three [4Fe-4S] clusters to capture and transfer the electrons …
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Biochemical Studies of the Sodium -Translocating NADH:ubiquinone Oxidoreductase
In the NqrF subunit, four conserved cysteines (C70, C76, C79 and C111) are predicted to ligate the 2Fe-2S center, and three conserved residues (R210, Y212, S245) are predicted to be essential to the binding of the FAD cofactor. By mutagenesis and spectroscopic characterization, the four conserved …
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The Heme -Copper Oxidoreductase Superfamily: Genomics and Structural Analyses
… the sequence diversity of the heme-copper oxidoreductase superfamily by analyzing over 1100 microbial genomes (Bacteria and Archaea) and nine microbial environmental metagenomic datasets. Over 2000 new putative members were found which we classify into eight oxygen reductase families (A-, …
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Molecular Studies of the Succinate:ubiquinone Oxidoreductase of Escherichia Coli
Succinate:ubiquinone oxidoreductase (Complex II) is a membrane-bound enzyme present in aerobically grown bacteria and in the mitochondria of eukaryotes. It functions as succinate dehydrogenase in the citric acid cycle and transfers reducing equivalents to ubiquinone in the aerobic electron …
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Structural and functional studies of mitochondrial NADH:ubiquinone oxidoreductase (complex I)
NADH:ubiquinone oxidoreductase (complex I) is the largest and most complicated enzyme in the mitochondrial electron transfer chain. It catalyses the oxidation of NADH and the reduction of ubiquinone, coupled to the translocation of protons across the mitochondrial inner membrane, maintaining the …
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Uncovering Biophysical Determinants Of Oxidoreductase Function Through De Novo Protein Design
Oxidoreductases are a diverse class of enzymes defined by their chemical role of transferring electrons from one substrate to another. Comprising the functional cores of photosynthetic, chemosynthetic, and cellular respiratory machinery, “redox proteins” and the catalysis they enable form the …
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Occurrence of pyruvate:ferredoxin oxidoreductase in Campylobacter, Wolinella, Helicobacter and Arcobacter species
Pyruvate:ferredoxin oxidoreductase activity was demonstrated in microaerophilic members of Campylobacter, Wolinella, and Helicobacter. Arcobacter cryaerophila (sic) and Arcobacter nitrofigilis, two aerobic species, lacked any detectable activity. Under anaerobic conditions crude extracts of …
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Functional roles of butyrophilin 1a1 and xanthine oxidoreductase in lactating mammary gland
Butyrophilin 1a1 (BTN) and xanthine oxidoreductase (XOR) are expressed in the lactating mammary gland and are secreted into milk in association with lipid droplets. Disruption of either the BTN or XOR gene in mice causes the accumulation of large pools of lipid in the cytoplasm, thus suggesting …
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Modeling metallo-oxidoreductase active site dynamics with bis(μ-hydroxo)dicobalt complexes
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Electron Transfer Reactions of the Ubiquinol: Cytochrome C-2 Oxidoreductase of Rhodopseudomonas Sphaeroides
… reactions of the ubiquinol:cytochrome c(,2) oxidoreductase (b-c(,1) complex) of the photosynthetic bacteria Rps. sphaeroides have been investigated through the use of optical spectroscopy and chemical inhibitors of the protein complex.
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Nad(p)h: Fmn Oxidoreductase of Photobacterium Fischeri: Its Role in Bacterial Bioluminescence
Made available in DSpace on 2014-12-09T17:36:33Z (GMT). No. of bitstreams: 1 7013292.pdf: 6207081 bytes, checksum: 4f051799ea2980f7923fe2b38e070660 (MD5) Previous issue date: 1969
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Quinol oxidation by the ubiquinol:cytochrome c(2) oxidoreductase in the chromatophores from Rhodobacter sphaeroides
The kinetics and thermodynamics of the high potential chain in the chromatophores from Rhodobacter sphaeroides have been reexamined. It was found that RC, cyt c$\sb2$ and c$\sb1$ after a flash reached a state not far from the expected ideal equilibrium under the conditions of our experiments.
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Kinetic studies of mechanism of ubiquinol:cytochrome c(2) oxidoreductase of Rhodobacter sphaeroides: A steady state approach
The work presented in this thesis is among the first efforts to study the mechanism of electron transfer through b/c$\sb1$ complex of R. sphaeroides under the coupled conditions. It aims at (1) establishing a kinetic model for b/c$\sb1$ complex in the presence of a substantial proton gradient and …
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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that catalyzes an NAD(P)H-dependent activation of many quinone-based antitumor agents. NQO1, expressed at high levels in many human solid tumors, can be used as a target for enzyme-directed bioreductive antitumor drug development. …
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NAD(P)H:QUINONE OXIDOREDUCTASE (NQO1)-DIRECTED LAVENDAMYCIN ANTITUMOR AGENTS: STRUCTURE-BASED DESIGN, MOLECULAR MODELING AND STRUCTURE-ACTIVITY STUDIES
NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that catalyzes an NAD(P)H-dependent activation of many quinone-based antitumor agents. NQO1, expressed at high levels in many human solid tumors, can be used as a target for enzyme-directed bioreductive antitumor drug development. …
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The Effect of Allopurinol and Inosine Administration on Xanthine Oxidoreductase Gene Expression, Mitochondrial Respiration, and Inflammation in Broiler Chickens
Birds have a remarkable longevity for their body size despite an increased body temperature, higher metabolic rate, and increased blood glucose concentrations. Theoretically, birds should sustain a much higher degree of oxidative damage yet do not, in part due to the powerful antioxidant, uric …
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Nitrite Mode of Action: The Inhibition of Yeast Pyruvate Decarboxylase and Clostridial Pyruvate:ferredoxin Oxidoreductase by Nitric Oxide and Menadione
Embargo set by: Seth Robbins for item 70267 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs
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Control of Shigella sonnei and adhesive invasive Escherichia coli infections with a natural product which inhibits the bacterial oxidoreductase DsbA
Many Gram-negative bacterial pathogens such as Shigella and adhesive invasive Escherichia coli (AIEC) cause infections characteristic of hyperinflammation. These infections require antimicrobial therapy. However, due to the widespread emergence of multiple drug-resistant strains, alternative …
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