Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"oxidized LDL"”.
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Development of a Passive Immunization Strategy Against Atherosclerosis
… claim millions of lives every year worldwide. Oxidized LDL and the immune system play very important roles in atherosclerosis. Several studies have demonstrated the existence of both atherogenic and atheroprotective immune responses against oxidized LDL. We have identified several of the …
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The Effects of Ketoconazole on the Oxidation of Low Density Lipoproteins by Bovine Aortic Smooth Muscle Cells
… modify human low-density lipoprotein (LDL). Such oxidized LDL appears to be a significant factor in the etiology of atherosclerosis. This work shows that the azole antifungal drug ketoconazole when added to the culture medium of BASMC inhibits LDL oxidation. Confluent BASMC were fed 1 …
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The effect of isoflavone supplementation on cardiovascular disease parameters in men undergoing 80% VO₂pk exercise
… of oxidative damage on low density lipoproteins (LDL). Current research shows that dietary antioxidant supplementation protects against oxidative stress, and therefore may present preventative measures and treatments for patients with diseases influenced by oxidative stress. Isoflavones found in …
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SERUM ANTI-PHOSPHORYLCHOLINE AND ANTI-CARDIOLIPIN CONCENTRATIONS FOLLOWING PERIODONTAL SCALING AND ROOT PLANING
… are the immune system and lipids; in particular, LDL which accumulates within the arterial walls and macrophages which recognize and engulf oxidized-LDL (oxLDL) to form foam cells. Knowing that certain antibodies directed against bacterial antigens such as phosphorylcholine (PC) and cardiolipin …
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Protective Immunity in Atherosclerosis
… against modified low density lipoprotein (LDL) are believed to promote development of atherosclerosis. Proinflammatory immune responses can be counterbalanced by immunosuppressive regulatory T cells (Tregs). Immunizations of hypercholesterolemic mice with oxidized LDL or peptides derived …
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Postprandial Effects of Pecans Ingestion on Plasma Level of Nutrients, Polyphenolic Compounds and Biomarkers of Antioxidant Status in Human Volunteers
… the greatest at 8-h (<em>p </em>= 0.013) and oxidized LDL at 3-h (<em>p </em>= 0.018). Our results indicate that antioxidants found in pecans may increase antioxidant capacity and ability, and therefore decrease oxidative stress. Regular consumption of pecans may contribute to a reduction in …
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Regulation of Platelet-Activating Factor Acetylhydrolase by Oxidized Phospholipids and Proinflammatory Cytokines
… in monocytes is increased in response to oxidized phospholipids. The PAFAH 5' flanking region has at least 10 putative Stat elements, and IL-6 has been shown to be downstream from the prostaglandin receptor, EP2, which has been shown to bind oxidized phospholipids, prompting the hypothesis …
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IL-25 and B cells in atherosclerosis
… targeting modified low density lipoprotein (LDL) play an important role in atherosclerosis. Moreover, Th1 immune responses have inextricably been associated with disease progression while the role of Th17 and Th2 related immune responses is less clear. In the present work we report that …
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Expression profiling of human macrophages and atherosclerotic plaques to identify genes and mechanisms that modulate the development of atherosclerosis
… antagonist (IL1RN) was down regulated by oxidized low-density lipoprotein (LDL), suggesting a novel pro-inflammatory role of oxidized LDL. Immunohistochemistry showed that the plaque specific gene chemokine CC motif ligand 18 (CCL18) co-localized with macrophages in the plaques. In …
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Markers and mechanisms of pre-eclampsia in pregnancies complicated by diabetes
… lines HTR8/SVneo and JAR were exposed to native LDL (N-LDL) vs. ‘highly-oxidized glycated’ LDL (HOG-LDL) (10-200 µg protein/ml) for 24 hours, with and without pre-treatment with 30 mM glucose for 72 hours. The mRNA expressions of sFlt-1 isoforms (sFlt-1-i13, sFlt-1-e15a), endoglin and MMP-14 were …
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Lipoprotein(a) and the risk of vascular disease
… is composed of a low density-lipoprotein (LDL) particle and a glycoprotein molecule known as apolipoprotein(a) [apo(a)]. Apo(a) exists in several differently-sized isoforms and is responsible for the unique properties of Lp(a). Although Lp(a) has been known for the past 40 years its …
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Characterization of Variable Region Structures and Antigen-Binding Properties of OxLDL-Specific Human Monoclonal Antibody Isolated from PBMC and Atherotic Plaques of Atherosclerosis Patients
… modification of low-density lipoprotein (LDL) plays an important role in the pathogenesis of atherosclerosis and the oxidized LDL (oxLDL) may represent a target for autoantibodies involved in the pathogenesis of the disease. The aim of this study was; first, analysis of the Ag-binding …